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Sensory neuron
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=== Internal receptors=== Internal receptors that respond to changes inside the body are known as '''interoceptors'''.<ref name="Campbell" /> ==== Blood ==== The [[aortic body|aortic bodies]] and [[carotid body|carotid bodies]] contain clusters of [[glomus cell]]s β [[peripheral chemoreceptors]] that detect changes in chemical properties in the blood such as [[oxygen]] concentration.<ref>{{cite journal |vauthors=Satir P, Christensen ST |title=Structure and function of mammalian cilia |journal=Histochem Cell Biol |volume=129 |issue=6 |pages=687β93 |date=June 2008 |pmid=18365235 |pmc=2386530 |doi=10.1007/s00418-008-0416-9 }}</ref> These receptors are [[Stimulus modality#polymodality|polymodal]] responding to a number of different stimuli. ==== Nociceptors ==== Nociceptors respond to potentially [[Noxious stimulus|damaging stimuli]] by sending signals to the spinal cord and brain. This process, called [[nociception]], usually causes the perception of [[pain]].<ref>Sherrington C. ''The Integrative Action of the Nervous System.'' Oxford: Oxford University Press; 1906.</ref><ref name="smith">{{cite journal | last=St. John Smith | first=Ewan | title=Advances in understanding nociception and neuropathic pain | journal=Journal of Neurology| volume=265 | issue=2 | date=2017-10-14 | issn=0340-5354 | pmid=29032407 | pmc=5808094 | doi=10.1007/s00415-017-8641-6 | pages=231β238}}</ref> They are found in internal organs as well as on the surface of the body to "detect and protect".<ref name=smith/> Nociceptors detect different kinds of noxious stimuli indicating potential for damage, then initiate neural responses to withdraw from the stimulus.<ref name=smith/> # ''Thermal'' nociceptors are activated by noxious heat or cold at various temperatures.<ref name="smith" /> # ''Mechanical'' nociceptors respond to excess pressure or mechanical deformation, such as a [[Pinch (action)|pinch]].<ref name="smith" /> # ''Chemical'' nociceptors respond to a wide variety of chemicals, some of which signal a response. They are involved in the detection of some spices in food, such as the pungent ingredients in [[Brassicaceae|Brassica]] and [[Allium]] plants, which target the sensory neural receptor to produce acute pain and subsequent pain hypersensitivity.<ref>{{Cite journal|last1=Zhao|first1=Jianhua|last2=Lin King|first2=John V.|last3=Paulsen|first3=Candice E.|last4=Cheng|first4=Yifan|last5=Julius|first5=David|date=2020-07-08|title=Irritant-evoked activation and calcium modulation of the TRPA1 receptor|journal=Nature|volume=585|issue=7823|pages=141β145|doi=10.1038/s41586-020-2480-9|issn=1476-4687|pmid=32641835|pmc=7483980|bibcode=2020Natur.585..141Z}}</ref>
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