Editing Serotonin transporter (section)

=== VNTR in STin2 ===
Another noncoding polymorphism is a [[VNTR]] in the second [[intron]] ([[STin2]]). In a 2005 study, it was found with three [[allele]]s: 9, 10 and 12 repeats.
A [[meta-analysis]] has found that the 12 repeat allele of the STin2 VNTR polymorphism had some minor (with [[odds ratio]] 1.24), but statistically significant, association with [[schizophrenia]].<ref>{{cite journal | vauthors = Fan JB, Sklar P | title = Meta-analysis reveals association between serotonin transporter gene STin2 VNTR polymorphism and schizophrenia | journal = Molecular Psychiatry | volume = 10 | issue = 10 | pages = 928–38, 891 | date = October 2005 | pmid = 15940296 | doi = 10.1038/sj.mp.4001690 | s2cid = 29240701 | doi-access =  }}</ref>
A 2008 meta-analysis found no significant overall association between the STin2 VNTR polymorphism and [[autism]].<ref name=Huang-Santangelo/>
Furthermore, a 2003 meta-analysis of [[affective disorder]]s, [[major depressive disorder]] and [[bipolar disorder]], found a minor association to the intron 2 VNTR polymorphism, but the results of the meta-analysis were dependent upon a large effect from one individual study.<ref>{{cite journal | vauthors = Anguelova M, Benkelfat C, Turecki G | title = A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: I. Affective disorders | journal = Molecular Psychiatry | volume = 8 | issue = 6 | pages = 574–591 | date = June 2003 | pmid = 12851635 | doi = 10.1038/sj.mp.4001328 | doi-access = free }}</ref>

The polymorphism has also been related to [[personality trait]]s with a 2008 Russian study finding individuals with the STin2.10 allele having lower [[neuroticism]] scores as measured with the [[Eysenck Personality Inventory]].<ref>{{cite journal | vauthors = Kazantseva AV, Gaysina DA, Faskhutdinova GG, Noskova T, Malykh SB, Khusnutdinova EK | title = Polymorphisms of the serotonin transporter gene (5-HTTLPR, A/G SNP in 5-HTTLPR, and STin2 VNTR) and their relation to personality traits in healthy individuals from Russia | journal = Psychiatric Genetics | volume = 18 | issue = 4 | pages = 167–176 | date = August 2008 | pmid = 18628678 | doi = 10.1097/YPG.0b013e328304deb8 | s2cid = 7423923 }}</ref>