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Transient receptor potential channel
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===TRPV=== {| class="wikitable" !Family !Sub-Family !Known Taxa <ref name="Peng" /><ref>{{cite journal | vauthors = Cattaneo AM, Bengtsson JM, Montagné N, Jacquin-Joly E, Rota-Stabelli O, Salvagnin U, Bassoli A, Witzgall P, Anfora G | display-authors = 6 | title = TRPA5, an Ankyrin Subfamily Insect TRP Channel, is Expressed in Antennae of Cydia pomonella (Lepidoptera: Tortricidae) in Multiple Splice Variants | journal = Journal of Insect Science | volume = 16 | issue = 1 | pages = 83 | date = 2016 | pmid = 27638948 | pmc = 5026476 | doi = 10.1093/jisesa/iew072 }}</ref> |- |rowspan="8" |TRPV |[[Nanchung]] |rowspan="2" |[[Placozoans]], cnidarians, nematodes, annelids, molluscs, and arthropods (possibly excluding [[arachnids]]) |- |[[Inactive]] |- |[[TRPV1]] |rowspan="6" |Specific to vertebrates |- |[[TRPV2]] |- |[[TRPV3]] |- |[[TRPV4]] |- |[[TRPV5]] |- |[[TRPV6]] |- |} TRPV, V for "vanilloid", was originally discovered in ''Caenorhabditis elegans'', and is named for the vanilloid chemicals that activate some of these channels.<ref name="Montell_2001">{{cite journal | vauthors = Montell C | title = Physiology, phylogeny, and functions of the TRP superfamily of cation channels | journal = Science's STKE | volume = 2001 | issue = 90 | pages = re1 | date = July 2001 | pmid = 11752662 | doi = 10.1126/stke.2001.90.re1 | s2cid = 37074808 }}</ref><ref>{{cite journal | vauthors = Colbert HA, Smith TL, Bargmann CI | title = OSM-9, a novel protein with structural similarity to channels, is required for olfaction, mechanosensation, and olfactory adaptation in Caenorhabditis elegans | journal = The Journal of Neuroscience | volume = 17 | issue = 21 | pages = 8259–69 | date = November 1997 | pmid = 9334401 | pmc = 6573730 | doi = 10.1523/JNEUROSCI.17-21-08259.1997 }}</ref> These channels have been made famous for their association with molecules such as [[capsaicin]] (a TRPV1 agonist).<ref name=":3" /> In addition to the 6 known vertebrate paralogues, 2 major clades are known outside of the deterostomes: nanchung and Iav. Mechanistic studies of these latter clades have been largely restricted to ''Drosophila'', but phylogenetic analyses has placed a number of other genes from Placozoa, Annelida, Cnidaria, Mollusca, and other arthropods within them.<ref name="Peng" /><ref>{{cite journal | vauthors = Gong Z, Son W, Chung YD, Kim J, Shin DW, McClung CA, Lee Y, Lee HW, Chang DJ, Kaang BK, Cho H, Oh U, Hirsh J, Kernan MJ, Kim C | display-authors = 6 | title = Two interdependent TRPV channel subunits, inactive and Nanchung, mediate hearing in Drosophila | journal = The Journal of Neuroscience | volume = 24 | issue = 41 | pages = 9059–66 | date = October 2004 | pmid = 15483124 | pmc = 6730075 | doi = 10.1523/JNEUROSCI.1645-04.2004 }}</ref><ref>{{cite journal | vauthors = Kim J, Chung YD, Park DY, Choi S, Shin DW, Soh H, Lee HW, Son W, Yim J, Park CS, Kernan MJ, Kim C | display-authors = 6 | title = A TRPV family ion channel required for hearing in Drosophila | journal = Nature | volume = 424 | issue = 6944 | pages = 81–4 | date = July 2003 | pmid = 12819662 | doi = 10.1038/nature01733 | s2cid = 4426696 | bibcode = 2003Natur.424...81K }}</ref> TRPV channels have also been described in protists.<ref name="Peng" />
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