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Ventral tegmental area
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=== Neural composition === The VTA, like the [[substantia nigra]], is populated with [[melanin]]-pigmented [[dopamine]]rgic neurons.<ref>{{cite web|url=http://cogprints.org/1390/2/vta-rev-87.pdf |title=Info |publisher=cogprints.org |access-date=2019-12-24}}</ref> Recent studies have suggested that dopaminergic neurons comprise 50-60% of all neurons in the VTA,<ref>{{cite journal | vauthors = Margolis EB, Lock H, Hjelmstad GO, Fields HL | title = The ventral tegmental area revisited: is there an electrophysiological marker for dopaminergic neurons? | journal = The Journal of Physiology | volume = 577 | issue = Pt 3 | pages = 907β24 | date = December 2006 | pmid = 16959856 | pmc = 1890372 | doi = 10.1113/jphysiol.2006.117069 }}</ref> which is contrary to previous evidence that noted 77% of neurons within the VTA to be dopaminergic.<ref name="Johnson 1992">{{cite journal | vauthors = Johnson SW, North RA | title = Two types of neurone in the rat ventral tegmental area and their synaptic inputs | journal = The Journal of Physiology | volume = 450 | pages = 455β68 | date = May 1992 | pmid = 1331427 | pmc = 1176131 | doi = 10.1113/jphysiol.1992.sp019136 }}</ref> In addition, there is a sizable population of GABAergic neurons in the [[rostromedial tegmental nucleus]] (RMTg), a functionally distinct brain structure.<ref name="VTA tail" /><ref name="Brake" /> These GABAergic neurons regulate the firing of their dopaminergic counterparts that send projections throughout the brain to, but not limited to, the following regions: the [[prefrontal cortex]], the [[nucleus accumbens]], and the [[locus coeruleus]]. The VTA also contains a small percentage of excitatory [[glutamatergic]] neurons.
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