Editing Antispasmodic

{{short description|Class of medications}}
An '''antispasmodic''' (synonym: '''spasmolytic''') is a [[pharmaceutical drug]] or other agent that suppresses muscle [[spasm]]s.<ref name=thefreedictionary>{{cite web |url=http://medical-dictionary.thefreedictionary.com/antispasmodic | work = thefreedictionary.com | title = Antispasmodic |access-date=February 1, 2016}}</ref>

==Smooth muscle spasm==
One type of antispasmodics is used for [[smooth muscle]] relaxation, especially in tubular organs of the [[gastrointestinal tract]]. The effect is to prevent spasms of the [[stomach]], [[intestine]] or [[urinary bladder]].
Both [[dicyclomine]] and [[hyoscyamine]] are antispasmodic due to their [[anticholinergic]] action.{{medcn|date=January 2024}} Both of these drugs have side effects common to anticholinergics and can worsen [[gastroesophageal reflux disease]] (GERD).<ref>{{cite journal |pmid=16370407 |url=http://www.aafp.org/link_out?pmid=16370407 |year=2005 |last1=Hadley |first1=S. K. |title=Treatment of irritable bowel syndrome |journal=American Family Physician |volume=72 |issue=12 |pages=2501–6 |last2=Gaarder |first2=S. M. }}</ref>

[[Papaverine]] is an [[opium]] [[alkaloid]] used to treat [[visceral]] spasms, particularly those of the intestines.<ref name=PMID16159054>{{cite journal | vauthors = Liu JK, Couldwell WT | title = Intra-arterial papaverine infusions for the treatment of cerebral vasospasm induced by aneurysmal subarachnoid hemorrhage | journal = Neurocritical Care | volume = 2 | issue = 2 | pages = 124–132 | year = 2005 | pmid = 16159054 | doi = 10.1385/NCC:2:2:124 | s2cid = 35400205 }}</ref> [[Mebeverine]] is a papaverine analog and spasmolytic with a strong and selective action on the smooth muscles of the gastrointestinal tract, particularly of the colon. Despite being anticholinergic, it does not have the systemic anticholinergic side effects seen in other such drugs.<ref name=UKlabel2016>{{cite web|title=Colofac Tablets 135mg - Summary of Product Characteristics (SPC)|url=https://www.medicines.org.uk/emc/medicine/2067|publisher=UK Electronic Medicines Compendium|access-date=21 July 2017|language=en|date=26 August 2016}}</ref>

[[Peppermint oil]] has been traditionally used as an antispasmodic, and a review of studies on the topic found that it "could be efficacious for symptom relief in [[irritable bowel syndrome|IBS]]"<ref name="pmid9672344">{{cite journal |pmid=9672344 |title=Peppermint oil for irritable bowel syndrome: A critical review and metaanalysis |journal=The American Journal of Gastroenterology |volume=93 |issue=7 |pages=1131–5 |year=1998 |last1=Pittler |first1=M.H. |last2=Ernst |first2=E. }}</ref> (as an antispasmodic) although more carefully controlled studies are needed. A later study showed it is an effective antispasmodic when test-applied topically to the intestine during [[endoscopy]].<ref name="pmid12665756">{{cite journal |doi=10.1067/mge.2003.156 |pmid=12665756 |title=Peppermint oil reduces gastric spasm during upper endoscopy: A randomized, double-blind, double-dummy controlled trial |journal=Gastrointestinal Endoscopy |volume=57 |issue=4 |pages=475–82 |year=2003 |last1=Hiki |first1=Naki |last2=Kurosaka |first2=Hanzou |last3=Tatsutomi |first3=Yusuke |last4=Shimoyama |first4=Shouji |last5=Tsuji |first5=Eiichi |last6=Kojima |first6=Junichi |last7=Shimizu |first7=Nobuyuki |last8=Ono |first8=Hitoshi |last9=Hirooka |first9=Tatsuo |last10=Noguchi |first10=Chiaki |last11=Mafune |first11=Ken-Ichi |last12=Kaminishi |first12=Michio }}</ref>

Bamboo shoots have been used for gastrointestinal and antispasmodic symptoms.{{medcn|date=January 2024}}

[[Anisotropine]], [[atropine]], [[clidinium bromide]] are also the most commonly used modern antispasmodics.{{CN|date=June 2019}}

==Skeletal muscle spasm==
{{See also|Muscle relaxant}}
Pharmacotherapy may be used for [[Acute (medicine)|acute]] [[musculoskeletal system|musculoskeletal]] conditions when [[physical therapy]] is unavailable or has not been fully successful. Another class of antispasmodics for such treatment includes [[cyclobenzaprine]], [[carisoprodol]], [[diazepam]], [[orphenadrine]], and [[tizanidine]].<ref name = chou>{{cite journal |doi=10.1016/j.jpainsymman.2004.05.002 |pmid=15276195 |title=Comparative efficacy and safety of skeletal muscle relaxants for spasticity and musculoskeletal conditions: A systematic review |journal=Journal of Pain and Symptom Management |volume=28 |issue=2 |pages=140–75 |year=2004 |last1=Chou |first1=Roger |last2=Peterson |first2=Kim |last3=Helfand |first3=Mark |doi-access=free }}</ref> [[Meprobamate]] is another effective antispasmodic which was first introduced for clinical usage in 1955 mainly as an [[anxiolytic]] and soon afterward became a blockbuster psychotropic drug. While clinical usage of meprobamate has largely become obsolete since the development of [[benzodiazepine]]s due to its liability for developing physical  [[substance dependence|dependence]] and severe toxicity during instances of acute  [[drug overdose|overdose]], it is still manufactured and available by prescription. Carisoprodol is similar to meprobamate as they both belong to the [[carbamate]] [[drug class]] and meprobamate is a clinically significant [[active metabolite]] of carisoprodol, although carisoprodol itself possesses additional antispasmodic properties which are distinct from its metabolites. Effectiveness has not been clearly shown for [[metaxalone]], [[methocarbamol]], [[chlorzoxazone]], [[baclofen]], or [[dantrolene]].<ref name = chou /> Applicable conditions include acute back<ref name=Medscape>{{cite web |url = http://www.medscape.com/viewarticle/572676_4 |title = Skeletal Muscle Relaxants |work = medscape.com |access-date = 27 January 2024 }}</ref> or neck pain, or pain after an injury. Long-term use of muscle relaxants in such cases is poorly supported.<ref name=Medscape/>

Spasm may also be seen in movement disorders featuring [[spasticity]] in neurologic conditions such as [[cerebral palsy]], [[multiple sclerosis]], and [[spinal cord disease]]. Medications are commonly used for spastic movement disorders, but research has not shown functional benefit for some drugs.<ref name="Taricco M 2000">{{cite journal |doi=10.1002/14651858.CD001131 |pmid=10796750 |title=Pharmacological interventions for spasticity following spinal cord injury |journal=Cochrane Database of Systematic Reviews |issue=2 |pages=CD001131 |year=2000 |last1=Taricco |first1=Mariangela |last2=Adone |first2=Roberto |last3=Pagliacci |first3=Christina |last4=Telaro |first4=Elena |pmc=8406943 }}</ref><ref>Shakespeare D, Boggild M, Young CA. Anti-spasticity agents for multiple sclerosis. Cochrane Database of Systematic Reviews 2003, Issue 4. Art. No.: CD001332. {{doi|10.1002/14651858.CD001332}}.</ref> Some studies have shown that medications have been effective in decreasing spasticity, but that this has not been accompanied by functional benefits.<ref name="Taricco M 2000"/> Medications such as [[baclofen]], [[tizanidine]], and [[dantrolene]] have been used.<ref name = chou />

==See also==
* [[Muscarinic antagonist]]
* [[Parasympatholytic]]
* [[Phloroglucinol]]
* [[Spasticity]]
* [[Propantheline bromide]]

==References==
{{reflist|2}}

==External links==
* {{MeshName|Antispasmodics}}

{{Urologicals}}
{{Irritable bowel syndrome}}

[[Category:Drugs acting on the gastrointestinal system and metabolism]]
[[Category:Antispasmodics| ]]