Editing Baroreceptor

{{Short description|Sensors detecting blood pressure}}
'''Baroreceptors''' (or archaically, '''pressoreceptors''') are [[stretch receptor]]s that sense [[blood pressure]]. Thus, increases in the pressure of blood vessel triggers increased [[action potential]] generation rates and provides information to the [[central nervous system]]. This sensory information is used primarily in [[autonomic nervous system|autonomic reflexes]] that in turn influence the heart [[cardiac output]] and vascular smooth muscle to influence vascular resistance.<ref>{{Cite journal|last=Heesch|first=C. M.|date=December 1999|title=Reflexes that control cardiovascular function|journal=The American Journal of Physiology|volume=277|issue=6 Pt 2|pages=S234–243|issn=0002-9513|pmid=10644250|doi=10.1152/advances.1999.277.6.S234|s2cid=21912789 }}</ref> Baroreceptors act immediately as part of a [[negative feedback]] system called the [[baroreflex]]<ref>Stanfield, CL; Germann, WJ. (2008) Principles of Human Physiology, Pearson Benjamin Cummings. 3rd edition, pp.427.</ref> as soon as there is a change from the usual [[Mean arterial pressure|mean arterial blood pressure]], returning the pressure toward a normal level. These reflexes help regulate short-term blood pressure. The [[solitary nucleus]] in the [[medulla oblongata]] of the brain recognizes changes in the firing rate of action potentials from the baroreceptors, and influences cardiac output and systemic vascular resistance.

Baroreceptors can be divided into two categories based on the type of blood vessel in which they are located: high-pressure arterial baroreceptors and low-pressure baroreceptors (also known as cardiopulmonary<ref>Levy, MN; Pappano, AJ. (2007) Cardiovascular Physiology, Mosby Elsevier. 9th edition, pp.172.</ref> or volume receptors<ref name="Stanfield, CL 2008 pp.430-431">Stanfield, CL; Germann, WJ. (2008) Principles of Human Physiology, Pearson Benjamin Cummings. 3rd edition, pp.430-431.</ref>).

==Arterial baroreceptors==

Arterial baroreceptors are located in the [[carotid sinus]] (at the bifurcation of [[common carotid artery]] into [[External carotid artery|external]] and [[Internal carotid artery|internal]] carotids) and in the [[aortic arch]].<ref>Reutersberg, B.; Pelisek, J.; Ouda, A.; de Rougemont, O.; Rössler, F.; Zimmermann, A. Baroreceptors in the Aortic Arch and Their Potential Role in Aortic Dissection and Aneurysms. J. Clin. Med. 2022, 11, 1161. https://doi.org/10.3390/jcm11051161</ref> The baroreceptors can identify the changes in both the average blood pressure or the rate of change in pressure with each arterial pulse. Action potentials triggered in the baroreceptor ending are then directly conducted to the brainstem where central terminations (synapses) transmit this information to neurons within the [[solitary nucleus]]<ref name=":0">{{Cite book|title=Physiology|last=Costanzo|first=Linda S.|isbn=9780323511896|edition= Sixth|location=Philadelphia, PA|oclc=965761862|date = 2017-03-15}}</ref> which lies in the medulla. Reflex responses from such baroreceptor activity can trigger increases or decreases in the heart rate. Arterial baroreceptor sensory endings are simple, splayed nerve endings that lie in the [[tunica adventitia]] of the artery. An increase in the mean arterial pressure increases [[depolarization]] of these sensory endings, which results in [[action potentials]]. These action potentials are conducted to the solitary nucleus in the central nervous system by [[axons]] and have a reflex effect on the cardiovascular system through [[Autonomic nervous system|autonomic]] neurons.<ref>Stanfield, CL; Germann, WJ. (2008) Principles of Human Physiology, Pearson Benjamin Cummings. 3rd edition, pp.424-425.</ref> [[Hormone]] secretions that target the heart and blood vessels are affected by the stimulation of baroreceptors.

At normal resting blood pressures, baroreceptors discharge with each heart beat. If blood pressure falls, such as on [[orthostatic hypotension]] or in [[hypovolaemic shock]], baroreceptor firing rate decreases and baroreceptor reflexes act to help restore blood pressure by increasing heart rate. Signals from the carotid baroreceptors are sent via the [[glossopharyngeal nerve]] ([[glossopharyngeal nerve|cranial nerve IX]]). Signals from the aortic baroreceptors travel through the [[vagus nerve]] ([[vagus nerve|cranial nerve X]]).<ref>Bray, JJ; Cragg, PA; Macknight, ADC; Mills, RG. (1999) Lecture Notes on Human Physiology, Blackwell Publishing. 4th edition, pp.379.</ref> Carotid sinus baroreceptors are responsive to both increases or decreases in arterial pressure, while aortic arch baroreceptors are only responsive to increases in arterial pressure.<ref name=":0" /> Arterial baroreceptors inform reflexes about arterial blood pressure but other stretch receptors in the large veins and right atrium convey information about the low pressure parts of the circulatory system.

Baroreceptors respond very quickly to maintain a stable blood pressure, but their responses diminish with time and thus are most effective for conveying short term changes in blood pressure. In people with [[essential hypertension]] the baroreceptors and their reflexes change and function to maintain the elevated blood pressure as if normal. The receptors then become less sensitive to change.<ref>Levy, MN; Pappano, AJ. (2007) Cardiovascular Physiology, Mosby Elsevier. 9th edition, pp.171.</ref>

Electrical stimulation of baroreceptors has been found to activate the [[baroreflex]], reducing sympathetic tone throughout the body and thereby reducing blood pressure in patients with resistant hypertension.<ref>{{cite journal|last1=Wallbach|first1=M|last2=Koziolek|first2=MJ|title=Baroreceptors in the carotid and hypertension-systematic review and meta-analysis of the effects of baroreflex activation therapy on blood pressure.|journal=Nephrology, Dialysis, Transplantation|volume=33|issue=9|pages=1485–1493|date=9 November 2017|doi=10.1093/ndt/gfx279|pmid=29136223|doi-access=free}}</ref>

==Low-pressure baroreceptors==
{{See also|Low pressure receptors}}
The low-pressure baroreceptors are found in large systemic [[vein]]s, in pulmonary vessels, and in the walls of the right atrium and ventricles of the [[heart]] (the [[atrial volume receptors]]).<ref name="Stanfield, CL 2008 pp.430-431" /> The low-pressure baroreceptors are involved with the regulation of blood volume. The blood volume determines the mean pressure throughout the system, in particular in the venous side where most of the blood is held.

The low-pressure baroreceptors have both circulatory and renal effects; they produce changes in [[hormone]] secretion, resulting in profound effects on the retention of [[osmoregulation|salt and water]]; they also influence intake of salt and water. The renal effects allow the receptors to change the long-term mean pressure in the system.

==Baroreceptor dysfunction==
Baroreceptors are integral to the body's function, as pressure changes in the blood vessels would not be detected as quickly in the absence of baroreceptors. When baroreceptors are not working, blood pressure continues to increase, but within an hour, the blood pressure returns to normal as other blood pressure regulatory systems take over.<ref>{{Cite journal|last=Guyton|first=Arthur C.|date=1991|title=Blood Pressure Control-Special Role of the Kidneys and Body Fluids|journal=Science|volume=252|issue=5014|pages=1813–1816|doi=10.1126/science.2063193|pmid=2063193|jstor=2875873|bibcode=1991Sci...252.1813G}}</ref>

Baroreceptors can also become oversensitive in some people (usually the carotid baroreceptors in older males). This can lead to [[bradycardia]], dizziness and [[syncope (medicine)|fainting (syncope)]] from touching the neck (often whilst shaving). This is an important cause to exclude in men having pre-syncope or syncope symptoms.

==References==
{{reflist}}

==External links==
* {{MeshName|Baroreceptors}}

{{Somatosensory system}}

[[Category:Sensory receptors]]
[[Category:Homeostasis]]
[[Category:Receptor cells]]