Editing Cryogenics

{{short description|Study of the production and behaviour of materials at very low temperatures}}
{{redirect|Low temperature physics|the journal|Low Temperature Physics (journal)}}
{{for-multi|cryopreservation of humans|Cryonics|the band|Cryogenic (band)}}
[[File:Liquidnitrogen.jpg|thumb|[[Liquid nitrogen|Nitrogen is a liquid]] under {{convert|-195.8|C|K}}. ]]
In [[physics]], '''cryogenics''' is the production and behaviour of materials at very low [[temperature]]s.

The 13th [[International Institute of Refrigeration]]'s (IIR) International Congress of Refrigeration (held in Washington, DC in 1971) endorsed a universal definition of "cryogenics" and "cryogenic" by accepting a threshold of {{convert|120|K|C}} to distinguish these terms from conventional refrigeration.<ref>International Dictionary of Refrigeration, http://dictionary.iifiir.org/search.php, {{Webarchive|url=https://web.archive.org/web/20191001210219/http://dictionary.iifiir.org/search.php|date=2019-10-01}}.</ref><ref>ASHRAE Terminology, https://www.ashrae.org/technical-resources/free-resources/ashrae-terminology.</ref><ref>"Cryogenics is usually defined as the science and technology dealing with temperatures less than about 120 K [4, 5], although this review does not adhere to a strict 120 K definition." K. D. Timmerhaus, R. Reed. ''Cryogenic Engineering: Fifty Years of Progress''. Springer Science+Business Media LLC (2007), chapter: 1.2, The Beginning of Cryogenics, p. 7.</ref><ref>{{cite web | url=https://trc.nist.gov/cryogenics/aboutCryogenics.html | title=About Cryogenics | quote=In terms of the Kelvin scale the cryogenic region is often considered to be that below approximately 120 K (−153 C).}}</ref> This is a logical dividing line, since the normal [[boiling point]]s of the so-called permanent [[gas]]es (such as [[helium]], [[hydrogen]], [[neon]], [[nitrogen]], [[oxygen]], and normal [[air]]) lie below 120&nbsp;K, while the [[Freon]] refrigerants, [[hydrocarbon]]s, and other common refrigerants have boiling points above 120&nbsp;K.<ref>{{Cite web|url=https://pubchem.ncbi.nlm.nih.gov/compound/dichlorodifluoromethane#section=Chemical-and-Physical-Properties|title=DICHLORODIFLUOROMETHANE at Pubchem}}</ref><ref>{{Cite web|url=https://pubchem.ncbi.nlm.nih.gov/compound/propane#section=Boiling-Point|title=PROPANE at Pubchem}}</ref>

Discovery of [[superconducting]] materials with critical temperatures significantly above the boiling point of nitrogen has provided new interest in reliable, low-cost methods of producing high-temperature cryogenic refrigeration. The term "high temperature cryogenic" describes temperatures ranging from above the boiling point of liquid nitrogen, {{convert|-195.79|°C|K °F|2}}, up to {{convert|-50|°C|K °F|0}}.<ref>J. M. Nash, 1991, "Vortex Expansion Devices for High Temperature Cryogenics", Proceedings of the 26th Intersociety Energy Conversion Engineering Conference, Vol. 4, pp. 521–525.</ref> The discovery of superconductive properties is first attributed to [[Heike Kamerlingh Onnes]] on July 10, 1908, after they were able to reach a temperature of 2&nbsp;K. These first superconductive properties were observed in mercury at a temperature of 4.2&nbsp;K.<ref>{{Citation |last=Radebaugh |first=R. |title=Historical Summary of Cryogenic Activity Prior to 1950 |date=2007 |work=Cryogenic Engineering |pages=3–27 |editor-last=Timmerhaus |editor-first=Klaus D. |series=International Cryogenics Monograph Series |place=New York, New York |publisher=Springer |language=en |bibcode=2007cren.book....3R |doi=10.1007/0-387-46896-x_1 |isbn=978-0-387-46896-9 |editor2-last=Reed |editor2-first=Richard P. |doi-access=free}}.</ref>

Cryogenicists use the [[Kelvin]] or [[Rankine scale|Rankine]] temperature scale, both of which measure from [[absolute zero]], rather than more usual scales such as [[Celsius]] which measures from the freezing point of water at sea level<ref>Celsius, Anders (1742) [https://archive.org/stream/kungligasvenskav1317kung#page/170/mode/2up/search "Observationer om twänne beständiga grader på en thermometer"] (Observations about two stable degrees on a thermometer), ''Kungliga Svenska Vetenskapsakademiens Handlingar'' (Proceedings of the Royal Swedish Academy of Sciences), '''3''': 171–180 and [https://archive.org/stream/kungligasvenskav1317kung#page/232/mode/2up Fig. 1.]</ref><ref name="EOC 1">[[Don Rittner]]; Ronald A. Bailey (2005): [https://books.google.com/books?id=Y2MNUNFg-8gC&pg=PA43 ''Encyclopedia of Chemistry.''] [[Facts On File]], [[Manhattan]], New York City, p. 43.</ref> or [[Fahrenheit]] which measures from the freezing point of a particular brine solution at sea level.<ref name=":0">[https://www.britannica.com/science/Fahrenheit-temperature-scale Fahrenheit temperature scale], Encyclopædia Britannica Online. 25 September 2015.</ref><ref>{{cite web|title=Fahrenheit: Facts, History & Conversion Formulas|url=https://www.livescience.com/39916-fahrenheit.html|access-date=2018-02-09|website=Live Science}}</ref>

== Definitions and distinctions ==

; Cryogenics: The branches of engineering that involve the study of very low temperatures (ultra low temperature i.e. below 123 K), how to produce them, and how materials behave at those temperatures.

; [[Cryobiology]]: The branch of [[biology]] involving the study of the effects of low temperatures on [[organism]]s (most often for the purpose of achieving [[cryopreservation]]). Other applications include Lyophilization (freeze-drying) of pharmaceutical<ref>{{Cite web |last=Evans |first=Nicole |title=What is Cryobiology? |url=https://www.societyforcryobiology.org/what-is-cryobiology#:~:text=Applications%20of%20cryobiology%20include:,adaptation%20of%20plants%20and%20animals. |access-date=2023-11-27 |website=www.societyforcryobiology.org |language=en-us}}</ref> components and medicine.

; [[Cryoconservation of animal genetic resources]]: The conservation of genetic material with the intention of conserving a breed. The conservation of genetic material is not limited to non-humans. Many services provide genetic storage or the preservation of [[stem cell]]s at birth. They may be used to study the generation of cell lines or for [[stem-cell therapy]].<ref>{{Cite journal |last=Hunt |first=Charles |date=April 3, 2011 |title=Cryopreservation of Human Stem Cells for Clinical Application: A Review |journal=Transfusion Medicine and Hemotherapy |volume=38 |issue=2 |pages=107–123 |doi=10.1159/000326623 |pmid=21566712 |pmc=3088734 }}</ref>

; [[Cryosurgery]]: The branch of surgery applying cryogenic temperatures to destroy and kill tissue, e.g. cancer cells. Commonly referred to as [[Cryoablation]].<ref>{{Cite web |date= June 21, 2021 |title=Cryosurgery to Treat Cancer |url=https://www.cancer.gov/about-cancer/treatment/types/surgery/cryosurgery |access-date=2023-11-27 |website=NCI |language=en}}</ref>

; [[Cryoelectronics]]: The study of electronic phenomena at cryogenic temperatures. Examples include [[superconductivity]] and [[variable-range hopping]].

; [[Cryonics]]: [[Cryopreservation|Cryopreserving]] humans and animals with the intention of future revival. "Cryogenics" is sometimes erroneously used to mean "Cryonics" in [[popular culture]] and the press.<ref>{{cite web|url=http://www.cryogenicsociety.org/cryonics/|title=Cryonics is NOT the Same as Cryogenics |website=Cryogenic Society of America |access-date=5 March 2013|archive-date=2 December 2018|archive-url=https://web.archive.org/web/20181202190822/https://cryogenicsociety.org/cryonics/|url-status=dead}}</ref>

== Etymology ==

The word ''cryogenics'' stems from [[Greek language|Greek]] ''κρύος (cryos)'' – "cold" + ''γενής (genis)'' – "generating".

== Cryogenic fluids==
[[File:ISIM 3 logical region.jpg|thumb|upright=2|This is a diagram of an infrared space telescope that needs a cold mirror and instruments. One instrument needs to be even colder, and it has a cryocooler. The instrument is in region 1 and its cryocooler is in region 3 in a warmer region of the spacecraft (see [[MIRI (Mid-Infrared Instrument)]] or [[James Webb Space Telescope]]).]]
Cryogenic fluids with their boiling point in [[Kelvin]]<ref>Randall Barron, CRYOGENIC SYSTEMS, [[McGraw-Hill Book Company]].</ref> and degree Celsius.
{| class="wikitable"
! Fluid !! Boiling point (K) !! Boiling point (°C)
|-
| Helium-3 || 3.19 || −269.96
|-
| Helium-4 || 4.214 || −268.936
|-
| Hydrogen || 20.27 || −252.88
|-
| Neon || 27.09 || −246.06
|-
| Nitrogen || 77.09 || −196.06
|-
| Air || 78.8 || −194.35
|-
| Fluorine || 85.24 || −187.91
|-
| Argon || 87.24 || −185.91
|-
| Oxygen || 90.18 || −182.97
|-
| Methane || 111.7 || −161.45
|-
| Krypton || 119.93 || −153.415
|}

== Industrial applications ==
[[File:Liquid Nitrogen Tank.JPG|thumb|A medium-sized [[Cryogenic storage dewar|dewar]] is being filled with liquid nitrogen by a larger cryogenic storage tank.]]
{{Multiple image
| total_width       = 330px
| image1            = Cryogenic carbon steel socket weld globe valve.jpg
| caption1          = Catalogue image of a cryogenic valve
| image2            = Iced nitrogen valves.jpg
| caption2          = Cryogenic valves in situ, heavily frozen from [[Deposition (phase transition)|condensed]] atmospheric [[humidity]]
}}
{{Further|Low-temperature technology timeline}}
[[Liquefied gas]]es, such as [[liquid nitrogen]] and [[liquid helium]], are used in many cryogenic applications. Liquid nitrogen is the most commonly used element in cryogenics and is legally purchasable around the world. Liquid helium is also commonly used and allows for the [[boiling point|lowest attainable temperatures]] to be reached.

These liquids may be stored in [[Dewar flask]]s, which are double-walled containers with a high vacuum between the walls to reduce heat transfer into the liquid. Typical laboratory Dewar flasks are spherical, made of glass and protected in a metal outer container. Dewar flasks for extremely cold liquids such as liquid helium have another double-walled container filled with liquid nitrogen. Dewar flasks are named after their inventor, [[James Dewar]], the man who first liquefied [[hydrogen]]. [[Thermos]] bottles are smaller [[vacuum flask]]s fitted in a protective casing.

Cryogenic barcode labels are used to mark Dewar flasks containing these liquids, and will not frost over down to −195 degrees Celsius.<ref>{{cite web|last1=Thermal|first1=Timmy|title=Cryogenic Labels|url=http://www.midcomdata.com/cryogenic-labels/|website=MidcomData|access-date=11 August 2014}}</ref>

Cryogenic transfer pumps are the pumps used on [[LNG pier]]s to transfer [[liquefied natural gas]] from [[LNG carrier]]s to [[LNG storage tank|LNG storage tanks]], as are cryogenic valves.

=== Cryogenic processing ===
The field of cryogenics advanced during World War II when scientists found that metals frozen to low temperatures showed more resistance to wear. Based on this theory of [[cryogenic hardening]], the commercial [[cryogenic processor|cryogenic processing]] industry was founded in 1966 by Bill and Ed Busch. With a background in the [[heat treating]] industry, the Busch brothers founded a company in [[Detroit]] called CryoTech in 1966.<ref>{{cite book|last1=Gantz|first1=Carroll|title=Refrigeration: A History|date=2015|publisher=McFarland & Company, Inc.|location=Jefferson, North Carolina|isbn=978-0-7864-7687-9|page=227|url=https://books.google.com/books?id=0UgjCgAAQBAJ&q=ed+busch+cryotech&pg=PA227}}</ref> Busch originally experimented with the possibility of increasing the life of metal tools to anywhere between 200% and 400% of the original life expectancy using [[cryogenic tempering]] instead of [[heat treating]].<ref>{{Cite book |last=Zohuri |first=Bahman |title=Physics of Cryogenics: An Ultralow Temperature Phenomenon |publisher=Elsevier |year=2018 |isbn=978-0-12-814519-7 |pages=34 |chapter=Chapter 1 - Cryogenic Technologies |doi=10.1016/C2017-0-01796-2}}</ref> This evolved in the late 1990s into the treatment of other parts.

Cryogens, such as liquid [[nitrogen]], are further used for specialty chilling and freezing applications. Some chemical reactions, like those used to produce the active ingredients for the popular [[statin]] drugs, must occur at low temperatures of approximately {{convert|−100|°C|°F}}. Special cryogenic [[chemical reactor]]s are used to remove reaction heat and provide a low temperature environment. The freezing of foods and biotechnology products, like [[vaccine]]s, requires nitrogen in blast freezing or immersion freezing systems. Certain soft or elastic materials become hard and [[brittle]] at very low temperatures, which makes cryogenic [[mill (grinding)|milling]] ([[cryomilling]]) an option for some materials that cannot easily be milled at higher temperatures.

Cryogenic processing is not a substitute for heat treatment, but rather an extension of the heating–quenching–tempering cycle. Normally, when an item is quenched, the final temperature is ambient. The only reason for this is that most heat treaters do not have cooling equipment. There is nothing metallurgically significant about ambient temperature. The cryogenic process continues this action from ambient temperature down to {{convert|-320|°F|°R K °C|0}}.
In most instances the cryogenic cycle is followed by a heat tempering procedure. As all alloys do not have the same chemical constituents, the tempering procedure varies according to the material's chemical composition, thermal history and/or a tool's particular service application.

The entire process takes 3–4 days.

=== Fuels ===
Another use of cryogenics is [[cryogenic fuel]]s for rockets with [[liquid hydrogen]] as the most widely used example, with [[liquid methane]] starting to become more prevalent in recent years. [[Liquid oxygen]] (LOX) is even more widely used but as an [[oxidizer]], not a fuel. [[NASA]]'s workhorse [[Space Shuttle]] used cryogenic hydrogen/oxygen propellant as its primary means of getting into [[orbit]]. LOX is also widely used with [[RP-1]] kerosene, a non-cryogenic hydrocarbon, such as in the rockets built for the [[Soviet space program]] by [[Sergei Korolev]].

Russian aircraft manufacturer [[Tupolev]] developed a version of its popular design [[Tu-154]] with a cryogenic fuel system, known as the [[Tu-155]]. The plane uses a fuel referred to as [[liquefied natural gas]] or LNG, and made its first flight in 1989.<ref>{{Cite web |title=Tu-155 / Tu-156 |url=https://www.globalsecurity.org/military/world/russia/tu-155.htm |access-date=2023-11-27 |website=www.globalsecurity.org}}</ref>

== Other applications ==
[[File:The MUSE instrument on the VLT.jpg|thumb|upright=1.4|Astronomical instruments on the [[Very Large Telescope]] are equipped with continuous-flow cooling systems.<ref>{{cite web|title=ESO Signs Technology Transfer Licence Agreement for Cooling System|url=http://www.eso.org/public/announcements/ann15041/|access-date=11 June 2015}}</ref>]]
Some applications of cryogenics:

* [[Nuclear magnetic resonance]] (NMR) is one of the most common methods to determine the physical and chemical properties of atoms by detecting the radio frequency absorbed and subsequent relaxation of nuclei in a magnetic field. This is one of the most commonly used characterization techniques and has applications in numerous fields. Primarily, the strong magnetic fields are generated by supercooling electromagnets, although there are [[Benchtop NMR spectrometer|spectrometers]] that do not require cryogens. In traditional superconducting solenoids, liquid helium is used to cool the inner coils because it has a boiling point of around 4 K at ambient pressure. Inexpensive metallic superconductors can be used for the coil wiring. So-called high-temperature superconducting compounds can be made to super conduct with the use of liquid nitrogen, which boils at around 77 K.
* [[Magnetic resonance imaging]] (MRI) is a complex application of NMR where the geometry of the resonances is deconvoluted and used to image objects by detecting the relaxation of protons that have been perturbed by a radio-frequency pulse in the strong magnetic field. This is most commonly used in health applications.
* [[Cryogenic electron microscopy]] (cryoEM) is a popular method in [[structural biology]] for elucidating the structures of [[Protein|proteins]], [[Cell (biology)|cells]], and other biological systems. Samples are plunge-frozen into a cryogen such as liquid ethane cooled by liquid nitrogen, and are then kept at liquid nitrogen temperature as they are inserted into an [[electron microscope]] for imaging. Electron microscopes are also themselves cooled by liquid nitrogen.
* In large cities, it is difficult to [[electric power transmission|transmit power]] by overhead cables, so underground cables are used. But underground cables get heated and the resistance of the wire increases, leading to waste of power. Superconductors could be used to increase power throughput, although they would require cryogenic liquids such as nitrogen or helium to cool special alloy-containing cables to increase power transmission. Several feasibility studies have been performed and the field is the subject of an agreement within the [[International Energy Agency]].
[[Image:Cryogenic Gases Delivery Truck Ypsilanti Michigan.JPG|thumb|right|250px|Cryogenic gases delivery truck at a supermarket, [[Ypsilanti, Michigan]]]]
* Cryogenic gases are used in transportation and storage of large masses of [[frozen food]]. When very large quantities of food must be transported to regions like war zones, earthquake hit regions, etc., they must be stored for a long time, so cryogenic food freezing is used. Cryogenic food freezing is also helpful for large scale food processing industries.
*Many infrared ([[forward looking infrared]]) cameras require their detectors to be cryogenically cooled.
* Certain rare blood groups are stored at low temperatures, such as −165°C, at blood banks.
* Cryogenics technology using [[liquid nitrogen]] and CO<sub>2</sub> has been built into [[nightclub]] effect systems to create a chilling effect and white fog that can be illuminated with colored lights.
* Cryogenic cooling is used to cool the tool tip at the time of machining in [[manufacturing process]]. It increases the tool life. Oxygen is used to perform several important functions in the steel manufacturing process.
* By freezing an automobile or truck tire in liquid nitrogen, the rubber is made brittle and can be crushed into small particles. These particles can be used again for other items.
* Experimental research on certain physics phenomena, such as [[spintronics]] and magnetotransport properties, requires cryogenic temperatures for the effects to be observable.
* Certain [[vaccine]]s must be stored at cryogenic temperatures. For example, the [[Pfizer–BioNTech COVID-19 vaccine]] must be stored at temperatures of {{convert|-90|to|-60|C|F}}. (See [[cold chain#Uses|cold chain]].)<ref name="Vaccination Storage">{{cite web | title=Pfizer–BioNTech COVID-19 Vaccine Vaccination Storage & Dry Ice Safety Handling | publisher=Pfizer-BioNTech | url=https://www.cvdvaccine-us.com/product-storage-and-dry-ice | access-date=17 December 2020 | archive-date=24 January 2021 | archive-url=https://web.archive.org/web/20210124024401/https://www.cvdvaccine-us.com/product-storage-and-dry-ice | url-status=dead }}</ref>

== Production ==
{{unreferenced section|date=March 2023}}
Cryogenic cooling of devices and material is usually achieved via the use of [[liquid nitrogen]], [[liquid helium]], or a [[Cryocooler|mechanical cryocooler]] (which uses high-pressure helium lines). [[Gifford-McMahon Refrigerator|Gifford-McMahon]] cryocoolers, [[Pulse tube refrigerator|pulse tube cryocoolers]] and [[Stirling engine#Stirling cryocoolers|Stirling cryocoolers]] are in wide use with selection based on required base temperature and cooling capacity. The most recent development in cryogenics is the use of magnets as regenerators as well as refrigerators. These devices work on the principle known as the [[magnetocaloric]] effect.

== Detectors ==

There are various [[cryogenic detectors]] which are used to detect<!-- cryogenic  <<  What is a 'croygenic' particle? --> particles.

For cryogenic temperature measurement down to 30 K, Pt100 sensors, a [[Resistance thermometer|resistance temperature detector (RTD)]], are used. For temperatures lower than 30 K, it is necessary to use a [[silicon bandgap temperature sensor|silicon diode]] for accuracy.

== See also ==
* [[Absolute zero]]
* [[Lowest temperature recorded on Earth]]
* [[Cryogenic grinding]]
* [[Flash freezing]]
* [[Frozen food]]

== References ==
{{Reflist}}

== Further reading ==
* Haselden, G. G. (1971), ''Cryogenic fundamentals'', Academic Press, New York, {{ISBN|0-12-330550-0}}.

{{Authority control}}

[[Category:Cryogenics| ]]
[[Category:Cooling technology]]
[[Category:Industrial gases]]