Editing Ischemia

{{short description|Restriction in blood supply to tissues}}
{{More citations needed|date=September 2020}}
{{Infobox medical condition (new)
| name            = Ischemia
| image           = Ischemia.JPG
| caption         = Vascular ischemia of the toes with characteristic [[cyanosis]]
| field           = [[Vascular surgery]]
| synonyms        = ischaemia, ischæmia
| pronounce       = {{IPAc-en|ɪ|ˈ|s|k|iː|m|i|ə}}<ref>''[[OED]]'' 2nd edition, 1989.</ref><ref>[http://www.merriam-webster.com/dictionary/ischemia Entry "ischemia"] in ''[http://www.merriam-webster.com/ Merriam-Webster Online Dictionary]''.</ref>
| symptoms        =
| complications   =
| onset           =
| duration        =
| types           =
| causes          =
| risks           =
| diagnosis       =
| differential    =
| prevention      =
| treatment       =
| medication      =
| prognosis       =
| frequency       =
| deaths          =
}}

'''Ischemia''' [[American and British English spelling differences#ae and oe|or]] '''ischaemia''' is a restriction in [[blood]] supply to any [[tissue (biology)|tissue]], [[Skeletal muscle|muscle group]], or [[Organ (biology)|organ]] of the body, causing a shortage of [[oxygen]] that is needed for [[cellular metabolism]] (to keep tissue alive).<ref>Merck & Co. [http://www.merckmanuals.com/home/heart_and_blood_vessel_disorders/peripheral_arterial_disease/occlusive_peripheral_arterial_disease.html#v722187 Occlusive Peripheral Arterial Disease], The Merck Manual Home Health Handbook website, revised and updated March 2010. Retrieved March 4, 2012.</ref><ref name="auto">{{Cite web|title=Chronic Limb-Threatening Ischemia (CLTI) – Vascular Cures|url=https://vascularcures.org/chronic-limb-threatening-ischemia-clti/|access-date=2021-10-27|language=en-US|archive-date=2021-10-29|archive-url=https://web.archive.org/web/20211029044416/https://vascularcures.org/chronic-limb-threatening-ischemia-clti/|url-status=dead}}</ref>  Ischemia is generally caused by problems with [[blood vessel]]s, with resultant damage to or dysfunction of tissue, i.e., [[Hypoxia (medical)|hypoxia]] and [[microvascular dysfunction]].<ref>Zhai Y, Petrowsky H, Hong JC,  et al: Ischaemia-reperfusion injury in liver transplantation—From bench to bedside. Nat Rev Gastroenterol Hepatol 2013; 10:79–89</ref><ref>Perico N, Cattaneo D, Sayegh MH, et al: Delayed graft function in kidney transplantation. Lancet 2004; 364:1814–1827</ref> It also implies local [[Hypoxia (medical)|hypoxia]] in a part of a body resulting from [[Vascular occlusion|constriction]] (such as [[vasoconstriction]], [[thrombosis]], or [[embolism]]). 

Ischemia causes not only insufficiency of oxygen but also reduced availability of [[nutrient]]s and inadequate removal of [[metabolic waste]]s.<ref>{{Cite web |title=Google Scholar |url=https://scholar.google.com/scholar_lookup?title=Cardiology%20Explained,%20London&publication_year=2004&author=E.A.%20Ashley&author=J.%20Niebauer |access-date=2024-08-26 |website=scholar.google.com}}</ref> Ischemia can be partial (poor [[perfusion]]) or total blockage. The inadequate delivery of oxygenated blood to the organs must be resolved either by treating the cause of the inadequate delivery or reducing the oxygen demand of the system that needs it. For example, patients with myocardial ischemia have a decreased blood flow to the heart and are prescribed with medications that reduce [[chronotropic]] and [[Inotrope|inotropic effect]] to meet the new level of blood delivery supplied by the [[Stenosis|stenosed vasculature]] so that it is adequate.

==Signs and symptoms==
The signs and symptoms of ischemia vary, as they can occur anywhere in the body and depend on the degree to which blood flow is interrupted.<ref name="auto"/> For example, clinical manifestations of [[Acute limb ischaemia|acute limb ischemia]] (which can be summarized as the '''"six Ps"''') include [[pain]], [[pallor]], [[pulseless]], [[paresthesia]], [[paralysis]], and [[Poikilotherm#In medicine|poikilothermia]].<ref>{{Citation|last1=Smith|first1=David A.|title=Acute Arterial Occlusion|date=2021|url=http://www.ncbi.nlm.nih.gov/books/NBK441851/|work=StatPearls|place=Treasure Island (FL)|publisher=StatPearls Publishing|pmid=28722881|access-date=2021-10-27|last2=Lilie|first2=Craig J.}}</ref>

Without immediate intervention, ischemia may progress quickly to tissue [[necrosis]] and [[gangrene]] within a few hours. [[Paralysis]] is a very late sign of acute arterial ischemia and signals the death of [[nerves]] supplying the extremity. [[Foot drop]] may occur as a result of [[nerve damage]]. Because nerves are extremely sensitive to [[hypoxia (medical)|hypoxia]], limb [[paralysis]] or ischemic [[neuropathy]] may persist after [[revascularization]] and may be permanent.<ref name=Lewis/>

=== Cardiac ischemia ===
{{main|Coronary ischemia|Coronary artery disease}}
Cardiac ischemia may be asymptomatic or may cause chest pain, known as [[angina pectoris]]. It occurs when the heart muscle, or [[myocardium]], receives insufficient blood flow.<ref>{{Cite web|title=Myocardial ischemia - Symptoms and causes|url=https://www.mayoclinic.org/diseases-conditions/myocardial-ischemia/symptoms-causes/syc-20375417|access-date=2021-10-27|website=Mayo Clinic|language=en}}</ref> This most frequently results from [[atherosclerosis]], which is the long-term accumulation of cholesterol-rich plaques in the [[coronary arteries]]. In most Western countries, [[Coronary artery disease|ischemic heart disease]] is the most common cause of death in both men and women, and a major cause of hospital admissions.<ref name=WHO>{{cite book |author= World Health Organization Department of Health Statistics and Informatics in the Information, Evidence and Research Cluster |title=The global burden of disease 2004 update |publisher=WHO |location=Geneva  |year=2004 |isbn=92-4-156371-0}}</ref><ref>{{Cite web|title=Coronary Artery Disease|url=https://medlineplus.gov/coronaryarterydisease.html|access-date=2021-10-27|website=medlineplus.gov}}</ref>

=== Bowel ===
{{Main|Intestinal ischemia}}
Both large and small intestines can be affected by ischemia. The blockage of blood flow to the [[large intestine]] (colon) is called [[ischemic colitis]].<ref>{{Cite web|title=Ischemic colitis - Symptoms and causes|url=https://www.mayoclinic.org/diseases-conditions/ischemic-colitis/symptoms-causes/syc-20374001|access-date=2021-10-27|website=Mayo Clinic|language=en}}</ref> Ischemia of the [[Small intestine|small bowel]] is called [[mesenteric ischemia]].<ref>{{Cite web|title=Acute Mesenteric Ischemia - Digestive Disorders|url=https://www.merckmanuals.com/home/digestive-disorders/gastrointestinal-emergencies/acute-mesenteric-ischemia|access-date=2021-10-27|website=Merck Manuals Consumer Version|language=en-US}}</ref>

=== Brain ===
{{Main|Brain ischemia|Ischemic stroke}}

[[Brain ischemia]] is insufficient blood flow to the [[brain]], and can be [[acute (medicine)|acute]] or [[chronic condition|chronic]]. Acute [[ischemic stroke]] is a neurological emergency typically caused by a blood clot blocking blood flow in a vessel in the brain.<ref>{{Cite web|title=Ischemic Stroke|url=https://medlineplus.gov/ischemicstroke.html|access-date=2021-10-27|website=medlineplus.gov}}</ref> Chronic ischemia of the brain may result in a form of [[dementia]] called [[vascular dementia]].<ref>{{cite journal|last1=Kuźma|first1=Elżbieta|last2=Lourida|first2=Ilianna|last3=Moore|first3=Sarah F.|last4=Levine|first4=Deborah A.|last5=Ukoumunne|first5=Obioha C.|last6=Llewellyn|first6=David J.|date=August 2018|title=Stroke and dementia risk: A systematic review and meta-analysis|url=https://www.alzheimersanddementia.com/article/S1552-5260(18)33250-3/abstract|journal=Alzheimer's & Dementia|volume=14|language=en|issue=11|pages=1416–1426|doi=10.1016/j.jalz.2018.06.3061|pmid=30177276|issn=1552-5260|pmc=6231970|hdl=2027.42/152961|access-date=2018-09-07|archive-date=2021-08-28|archive-url=https://web.archive.org/web/20210828131059/https://alz-journals.onlinelibrary.wiley.com/journal/15525279|url-status=dead}}</ref> A sudden, brief episode (symptoms lasting only minutes) of ischemia affecting the brain is called a [[transient ischemic attack]] (TIA), often called a mini-stroke.<ref name="auto1">{{Cite web|title=Transient Ischemic Attack|url=https://medlineplus.gov/transientischemicattack.html|access-date=2021-10-27|website=medlineplus.gov}}</ref> TIAs can be a warning of future strokes, with approximately 1/3 of TIA patients having a serious stroke within one year.<ref name="auto1"/><ref>{{Cite web|title=What is a TIA|url=https://www.stroke.org/en/about-stroke/types-of-stroke/tia-transient-ischemic-attack/what-is-a-tia|access-date=2021-10-27|website=www.stroke.org|language=en}}</ref>

=== Limb ===
{{main|Acute limb ischaemia|Chronic limb threatening ischemia}}

Inadequate blood supply to a [[Limb (anatomy)|limb]] may result in [[Acute limb ischaemia|acute limb ischemia]] or [[chronic limb threatening ischemia]].

=== Cutaneous ===
{{See also|Cyanosis|Gangrene}}
Reduced blood flow to the skin layers may result in [[mottling]] or uneven, patchy discoloration of the skin.

=== Kidney ischemia ===
[[Kidney ischemia]] is a loss of blood flow to the kidney cells. Several physical symptoms include shrinkage of one or both kidneys,<ref name=":0">{{cite journal|url=https://journals.lww.com/jhypertension/abstract/1997/15120/ischemic_renal_disease__an_emerging_cause_of.1.aspx|author-last1=Preston|author-first1=Richard A. |author-last2=Epstein|author-first2=Murray|title=Ischemic renal disease: an emerging cause of chronic renal failure and end-stage renal disease|journal=Journal of Hypertension|volume=15|number=12|pages=1365-1377|date=December 1997|access-date=2020-12-20}}</ref> [[renovascular hypertension]],<ref>{{Cite web|title=Renovascular hypertension: MedlinePlus Medical Encyclopedia|url=https://medlineplus.gov/ency/article/000204.htm|access-date=2020-12-20|website=medlineplus.gov|language=en}}</ref> [[Acute kidney injury|acute renal failure]],<ref name=":0" /> progressive azotemia,<ref name=":0" /> and acute [[pulmonary edema]].<ref name=":0" /> It is a disease with high mortality rate and high morbidity.<ref>{{Cite journal|last1=Sharfuddin|first1=Asif A.|last2=Molitoris|first2=Bruce A.|date=April 2011|title=Pathophysiology of ischemic acute kidney injury|url=https://www.nature.com/articles/nrneph.2011.16|journal=Nature Reviews Nephrology|language=en|volume=7|issue=4|pages=189–200|doi=10.1038/nrneph.2011.16|pmid=21364518|s2cid=32234965|issn=1759-507X|url-access=subscription}}</ref> Failure to treat could cause [[chronic kidney disease]]<ref>{{Cite journal|last1=Zuk|first1=Anna|last2=Bonventre|first2=Joseph V.|date=2016-01-14|title=Acute Kidney Injury|journal=Annual Review of Medicine|volume=67|issue=1|pages=293–307|doi=10.1146/annurev-med-050214-013407|issn=0066-4219|pmc=4845743|pmid=26768243}}</ref> and a need for renal surgery.<ref>{{Cite journal|last1=Munshi|first1=Raj|last2=Hsu|first2=Christine|last3=Himmelfarb|first3=Jonathan|date=2011-02-02|title=Advances in understanding ischemic acute kidney injury|url= |journal=BMC Medicine|volume=9|issue=1|pages=11|doi=10.1186/1741-7015-9-11|issn=1741-7015|pmc=3038966|pmid=21288330 |doi-access=free }}</ref>

==Causes==
Ischemia is a [[vascular disease]] involving an interruption in the arterial [[blood supply]] to a [[tissue (biology)|tissue]], [[organ (biology)|organ]], or extremity that, if untreated, can lead to tissue death. It can be caused by [[embolism]], [[thrombosis]] of an [[atherosclerosis|atherosclerotic]] artery, or trauma. [[Venous]] problems like venous outflow obstruction and low-flow states can cause [[acute arterial ischemic disorder|acute arterial ischemia]].  An [[aneurysm]] is one of the most frequent causes of acute arterial ischemia. Other causes are heart conditions including [[myocardial infarction]], [[mitral valve disease]], chronic [[atrial fibrillation]], [[cardiomyopathies]], and [[prosthesis]], in all of which [[thrombi]] are prone to develop.<ref name=Lewis>Lewis. S.L (2008). ''Medical-Surgical Nursing'' (7th ed.). Vascular disorder. pp. 907–908.</ref>

===Occlusion===
The [[thrombi]] may dislodge and may travel anywhere in the [[circulatory system]], where they may lead to [[pulmonary embolus]], an acute arterial [[Vascular occlusion|occlusion]] causing the oxygen and [[blood supply]] distal to the [[embolus]] to decrease suddenly. The degree and extent of symptoms depend on the size and location of the [[obstruction (blood vessel)|obstruction]], the occurrence of [[clot]] fragmentation with [[embolism]] to smaller vessels, and the degree of [[peripheral arterial disease]] (PAD).<ref name=Lewis/>
* [[Thromboembolism]] (blood clots)
* [[Embolism]] (foreign bodies in the circulation, e.g. [[amniotic fluid embolism]])

===Trauma===
[[Traumatic injury]] to an extremity may produce partial or total occlusion of a vessel from [[compression (physical)|compression]], [[shearing (physics)|shearing]], or [[laceration]]. Acute arterial occlusion may develop as a result of [[arterial dissection]] in the [[carotid artery]] or [[aorta]] or as a result of [[iatrogenic]] arterial injury (e.g., after [[angiography]]).<ref name=Lewis/>

===Other===
An inadequate flow of blood to a part of the body may be caused by any of the following:
* [[Thoracic outlet syndrome]] (compression of the [[brachial plexus]])
* [[Atherosclerosis]] (lipid-laden plaques obstructing the [[lumen (anatomy)|lumen]] of [[artery|arteries]])
* [[Hypoglycemia]] (lower than normal level of glucose)
* [[Tachycardia]] (abnormally rapid beating of the [[heart]])
* [[Radiotherapy]], [[Radiation therapy#Effects on subsequent surgery|therapeutic radiation]] used to treat cancer can cause a delayed side effect injury in adjacent tissue via [[Obliterating endarteritis|progressive, proliferative endarteritis]], inflamed arterial linings that disrupt the tissue's blood supply.<ref name="PMID 29261879">{{cite journal |last1=Cooper |first1=Jeffrey S. |last2=Hanley |first2=Mary E. |last3=Hendriksen |first3=Stephen |last4=Robins |first4=Marc |title=Hyperbaric Treatment of Delayed Radiation Injury |url=https://www.ncbi.nlm.nih.gov/books/NBK470447/ |website=www.ncbi.nlm.nih.gov |publisher=National Center for Biotechnology Information |access-date=23 July 2023 |date=August 30, 2022|pmid=29261879 }}</ref>
* [[Hypotension]] (low blood pressure, e.g. in [[septic shock]], [[heart failure]])
* Outside compression of a blood vessel, e.g. by a [[tumor]] or in the case of [[superior mesenteric artery syndrome]]
* [[Sickle cell disease]] (abnormally shaped red blood cells)
* Induced [[g-force]]s which restrict the blood flow and force the blood to the extremities of the body, as in acrobatics and military flying
* Localized extreme cold, such as by [[frostbite]] or improper [[cold compression therapy]]
* [[Tourniquet]] application
* An increased level of [[glutamate receptor]] stimulation <ref>{{cite journal |last1=Kostandy |first1=Botros B. |title=The role of glutamate in neuronal ischemic injury: the role of spark in fire |journal=Neurol Sci |date=2012 |volume=33 |issue=2 |pages=223–237 |doi=10.1007/s10072-011-0828-5|pmid=22044990 |s2cid=18769752 }}</ref>
* [[Arteriovenous malformation]]s and [[peripheral artery occlusive disease]]
* [[Hemorrhage|rupture of significant blood vessels]] supplying a tissue or organ.
* [[Anemia]] vasoconstricts the periphery so that red blood cells cannot work internally on vital organs such as the heart, brain, etc., thus causing lack of oxygen to the periphery.
* Premature discontinuation of any oral anticoagulant.
* [[Unconsciousness]], such as due to the ingestion of excessive doses of [[central depressant]]s like [[drinking alcohol|alcohol]] or [[opioid]]s, can result in ischemia of the extremities due to unusual body positions that prevent normal circulation

==Pathophysiology==

[[File:Ischemic preconditioning of the heart.png|thumb|300px| Native records of contractile activity of the left ventricle of isolated rat heart perfused under [[Langendorff heart|Langendorff technique]]. Curve A - contractile function of the heart is greatly depressed after ischemia-reperfusion. Curve B - a set of short ischemic episodes ([[ischemic preconditioning]]) before prolonged ischemia provides functional recovery of contractile activity of the heart at reperfusion.]]

{{Main|Ischemic cascade}}
Ischemia results in tissue damage in a process known as [[ischemic cascade]]. The damage is the result of the build-up of [[metabolic waste]] products, inability to maintain [[cell membranes]], [[mitochondria]]l damage, and eventual leakage of [[Autolysis (biology)|autolyzing]] [[proteolysis|proteolytic]] [[enzymes]] into the cell and surrounding tissues.<ref>{{cite journal |author1=McNeer JF |author2=Margolis JR | year = 1978 | title = The role of the exercise test in the evaluation of patients for ischemic heart disease |journal= Circulation|volume=57 |issue=1 | pages = 64–68 | doi = 10.1161/01.cir.57.1.64 | pmid = 618399 |s2cid=2552899 |doi-access=free }}</ref>

Restoration of blood supply to ischemic tissues can cause additional damage known as [[reperfusion injury]] that can be more damaging than the initial ischemia. Reintroduction of blood flow brings oxygen back to the tissues, causing a greater production of [[radical (chemistry)|free radicals]] and [[reactive oxygen species]] that damage cells.  It also brings more calcium ions to the tissues causing further calcium overloading and can result in potentially fatal [[cardiac arrhythmia]]s and also accelerates cellular [[apoptosis]]. The restored blood flow also exaggerates the [[inflammation]] response of damaged tissues, causing [[macrophage|white blood cells]] to destroy damaged cells that may otherwise still be viable.<ref>{{cite journal |author1=Sims N.R. |author2=Muyderman H. | year = 2010 | title = Mitochondria, oxidative metabolism and cell death in stroke |journal=[[Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease]] | url =https://hal.archives-ouvertes.fr/hal-00562934/file/PEER_stage2_10.1016%252Fj.bbadis.2009.09.003.pdf | volume = 1802 | issue = 1| pages = 80–91 | doi = 10.1016/j.bbadis.2009.09.003 | pmid = 19751827 }}</ref>

== Treatment ==

Early treatment is essential to keep the affected organ viable. The treatment options include injection of an [[anticoagulant]], [[thrombolysis]], [[embolectomy]], surgical revascularization, or partial amputation. Anticoagulant therapy is initiated to prevent further enlargement of the [[thrombus]]. Continuous IV [[unfractionated heparin]] has been the traditional agent of choice.<ref name=Lewis/>

If the condition of the ischemic limb is stabilized with [[anticoagulation]], recently formed [[emboli]] may be treated with catheter-directed [[thrombolysis]] using intra-arterial [[infusion]] of a [[thrombolytic]] agent (e.g., recombinant tissue plasminogen activator ([[Tissue plasminogen activator|tPA]]), [[streptokinase]], or [[urokinase]]). A percutaneous [[catheter]] inserted into the [[femoral artery]] and threaded to the site of the [[clot]] is used to infuse the drug. Unlike [[anticoagulant]]s, [[thrombolytic]] agents work directly to resolve the clot over a period of 24 to 48 hours.<ref name=Lewis/>

Direct [[arteriotomy]] may be necessary to remove the clot. Surgical [[revascularization]] may be used in the setting of trauma (e.g., laceration of the artery). [[Amputation]] is reserved for cases where limb salvage is not possible. If the patient continues to have a risk of further [[embolization]] from some persistent source, such as chronic [[atrial fibrillation]], treatment includes long-term oral [[anticoagulation]] to prevent further acute arterial ischemic episodes.<ref name=Lewis/>

Decrease in body temperature reduces the aerobic metabolic rate of the affected cells, reducing the immediate effects of [[Hypoxia (medical)|hypoxia]].  Reduction of body temperature also reduces the inflammation response and reperfusion injury. For frostbite injuries, limiting thawing and warming of tissues until warmer temperatures can be sustained may reduce [[reperfusion injury]].

Ischemic stroke is at times treated with various levels of [[statin]] therapy at hospital discharge, followed by home time, in an attempt to lower the risk of adverse events.<ref>{{Cite journal|last1=Li|first1=Yi-Heng|last2=Ueng|first2=Kwo-Chang|last3=Jeng|first3=Jiann-Shing|last4=Charng|first4=Min-Ji|last5=Lin|first5=Tsung-Hsien|last6=Chien|first6=Kuo-Liong|last7=Wang|first7=Chih-Yuan|last8=Chao|first8=Ting-Hsing|last9=Liu|first9=Ping-Yen|date=2017-04-01|title=2017 Taiwan lipid guidelines for high risk patients|journal=Journal of the Formosan Medical Association|volume=116|issue=4|pages=217–248|doi=10.1016/j.jfma.2016.11.013|pmid=28242176|issn=0929-6646|doi-access=free}}</ref><ref>{{Cite journal|last1=O'Brien|first1=Emily C.|last2=Greiner|first2=Melissa A.|last3=Xian|first3=Ying|last4=Fonarow|first4=Gregg C.|author-link5=DaiWai Olson|last5=Olson|first5=DaiWai M.|last6=Schwamm|first6=Lee H.|last7=Bhatt|first7=Deepak L.|last8=Smith|first8=Eric E.|last9=Maisch|first9=Lesley|date=2015-10-13|title=Clinical Effectiveness of Statin Therapy After Ischemic Stroke: Primary Results From the Statin Therapeutic Area of the Patient-Centered Research Into Outcomes Stroke Patients Prefer and Effectiveness Research (PROSPER) Study|journal=Circulation|language=en|volume=132|issue=15|pages=1404–1413|doi=10.1161/CIRCULATIONAHA.115.016183|pmid=26246175|s2cid=11252336|issn=0009-7322|doi-access=free}}</ref>

==Society and culture==
The Infarct Combat Project (ICP) is an international [[nonprofit organization]] founded in 1998 to fight [[ischemic heart disease]] through education and research.<ref>[http://www.infarctcombat.org Infarct Combat Project website]; accessed October 26, 2015.</ref>

==Etymology and pronunciation==
The word ''ischemia'' ({{IPAc-en|ɪ|ˈ|s|k|iː|m|i|ə}}) is from [[Greek language|Greek]] ἴσχαιμος ''iskhaimos'' 'staunching blood', from ἴσχω ''iskhο'' 'keep back, restrain' and αἷμα ''haima'' 'blood'.

==See also==
{{Portal|Medicine}}
<!-- alphabetical order please [[WP:SEEALSO]] -->
<!-- please add a short description [[WP:SEEALSO]], via {{subst:AnnotatedListOfLinks}} or {{Annotated link}} -->
{{div col|colwidth=20em|small=yes}}
* {{Annotated link |Ischemia-reperfusion injury of the appendicular musculoskeletal system}}
* {{Annotated link |Infarction}}
* {{Annotated link |Inhibitor protein}}
* {{Annotated link |Trauma triad of death}}
{{div col end}}
<!-- alphabetical order please [[WP:SEEALSO]] -->

== References ==
{{reflist}}

==Bibliography==
* Elizabeth (editor). [https://books.google.com/books?id=FDjBLDoxsJMC&pg=PA107 Oxford Reference: ''Concise Medical Dictionary''] (1990, 3rd ed.). Oxford University Press: Market House Books, 1987, 2nd ed., pp. 107, {{ISBN|978-0-19-281991-8}}

==External links==
{{Wiktionary}}
* {{cci}}

{{Hemodynamics}}
{{Pathology}}
{{Authority control}}

[[Category:Ischemia| ]]
[[Category:Angiology]]