Editing Soft-tissue sarcoma

{{Short description|Malignant tumor that develops in soft tissue}}
{{Infobox medical condition (new)
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| caption         = Undifferentiated soft tissue sarcoma in left lung of young child
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A '''soft-tissue sarcoma''' ('''STS''') is a [[Malignancy|malignant]] [[tumor]], a type of [[cancer]], that develops in [[soft tissue]].<ref name="Ratan">{{cite journal |last1=Ratan |first1=R |last2=Patel |first2=SR |title=Chemotherapy for soft tissue sarcoma. |journal=Cancer |date=October 2016 |volume=122 |issue=19 |pages=2952–60 |doi=10.1002/cncr.30191 |doi-access=free |pmid=27434055}}</ref> A soft-tissue [[sarcoma]] is often a painless mass that grows slowly over months or years. They may be superficial or deep-seated. Any such unexplained mass must be diagnosed by [[biopsy]].<ref name="Ferri"/> Treatment may include [[surgery]], [[radiotherapy]], [[chemotherapy]], and [[Targeted therapy|targeted drug therapy]].<ref name="STS">{{cite web |title=Treating Soft Tissue Sarcomas |url=https://www.cancer.org/cancer/soft-tissue-sarcoma/treating.html |website=www.cancer.org |access-date=1 August 2020 |language=en}}</ref> [[Bone sarcoma]]s are the other class of sarcomas.

There are many different types, many of which are rarely found.<ref name="CRUK">{{cite web |title=Types of soft tissue sarcoma {{!}} Cancer Research UK |url=https://about-cancer.cancerresearchuk.org/about-cancer/soft-tissue-sarcoma/types?_ga=2.43167143.322311465.1569566414-876143559.1415373757 |website=about-cancer.cancerresearchuk.org |access-date=27 September 2019}}</ref> The [[World Health Organization]] lists more than fifty subtypes.<ref name="Ferri">{{cite book |last1=Ferri |first1=Fred |title=Ferri's clinical advisor 2019 : 5 books in 1 |date=2019 |publisher=Elsevier |isbn=9780323530422 |page=1219}}</ref>

==Types==
{| class="wikitable plainrowheaders"
|+ Table 1: Major types of soft-tissue sarcomas in adults
|- style="vertical-align: top;"
! scope="col" | Tissue of origin
! scope="col" | Type of cancer
! scope="col" | Usual location in the body
|- style="vertical-align: top;"
! scope="row" style="text-align: left;" rowspan=3 | Fibrous tissue
| [[Undifferentiated pleomorphic sarcoma]] (UPS)
| Legs
|- style="vertical-align: top;"
| [[Dermatofibrosarcoma protuberans]]
| Trunk
|-
|[[Synovial sarcoma]]
|Legs
|- style="vertical-align: top;"
! scope="row" style="text-align: left;" | Fat
| [[Liposarcoma]]
| Arms, legs, trunk
|- style="vertical-align: top;"
! scope="row" style="text-align: left;" | Muscle (striated)
| [[Rhabdomyosarcoma]]
| Arms, legs
|- style="vertical-align: top;"
! scope="row" style="text-align: left;" | Muscle (smooth)
| [[Leiomyosarcoma]]
| Uterus, digestive tract
|- style="vertical-align: top;"
! scope="row" style="text-align: left;" rowspan=2 | Blood vessels
| [[Angiosarcoma]]
| Arms, legs, trunk, radiated tissues
|- style="vertical-align: top;"
| [[Kaposi's sarcoma|Kaposi sarcoma]] || Legs, trunk
|- style="vertical-align: top;"
! scope="row" style="text-align: left;" | Lymph vessels
| [[Angiosarcoma]]
| Arms
|- style="vertical-align: top;"
! scope="row" style="text-align: left;" | Peripheral nerves
| [[Malignant peripheral nerve sheath tumor]] / [[Neurofibrosarcoma]]
| Arms, legs, trunk
|- style="vertical-align: top;"
! scope="row" style="text-align: left;" rowspan=2 | Cartilage and bone-forming tissue
| Extraskeletal myxoid [[chondrosarcoma]]
| Legs
|- style="vertical-align: top;"
| Extraskeletal [[osteosarcoma]] || Legs, trunk (not involving the bone)
|}

{| class="wikitable plainrowheaders"
|+ Table 2: Major types of soft-tissue sarcomas in children
|- style="vertical-align: top;"
! scope="col" | Tissue of origin
! scope="col" | Type of cancer
! scope="col" | Most common locations in the body
! scope="col" | Most common ages
|- style="vertical-align: top;"
! rowspan="2" scope="row" style="text-align: left;" | Muscle (striated)
| Embryonal and Alveolar rhabdomyosarcoma
|Head and neck, genitourinary tract
|Infant–6
|- style="vertical-align: top;"
| [[Alveolar soft part sarcoma]]
| Arms, legs, head, and neck
| 10–19
|- style="vertical-align: top;"
! scope="row" style="text-align: left;" | Muscle (smooth)
| Leiomyosarcoma
| Trunk
| 15-35+
|- style="vertical-align: top;"
! rowspan="3" scope="row" style="text-align: left;" | Fibrous tissue
| Undifferentiated pleomorphic sarcoma
| Legs
| 15–19+
|- style="vertical-align: top;"
| Dermatofibrosarcoma protuberans
| Trunk
| 15–19
|- style="vertical-align: top;"
| Synovial sarcoma
| Legs, arms, and trunk
| 15–35
|- style="vertical-align: top;"
! scope="row" style="text-align: left;" | Fat
| Liposarcoma
| Arms and Legs
| 15–19+
|- style="vertical-align: top;"
! scope="row" style="text-align: left;" | Peripheral nerves
| Malignant peripheral nerve sheath tumors (also called neurofibrosarcomas)
| Arms, legs, and trunk
| 15–19+
|- style="vertical-align: top;"
! scope="row" style="text-align: left;" | Cartilage and bone-forming tissue
| [[Extraskeletal myxoid chondrosarcoma]]
| Legs
| 15-35
|}''An earlier version of this article was taken from the [[United States|US]] [[National Cancer Institute|National Cancer Center]]'s Cancer Information Service. The names of several sarcomas have changed over time.''

{{also|Skin sarcoma}}

== Signs and symptoms ==
In their early stages, soft-tissue sarcomas usually do not cause symptoms. Because soft tissue is relatively elastic, tumors can grow rather large, pushing aside normal tissue, before they are felt or cause any problems. The first noticeable symptom is usually a painless lump or swelling. As the tumor grows, it may cause other symptoms, such as pain or soreness, as it presses against nearby nerves and muscles. If in the abdomen it can cause abdominal pains commonly mistaken for menstrual cramps, indigestion, or cause constipation.<ref name=":0">{{Cite journal |last1=Gronchi |first1=A. |last2=Miah |first2=A. B. |last3=Dei Tos |first3=A. P. |last4=Abecassis |first4=N. |last5=Bajpai |first5=J. |last6=Bauer |first6=S. |last7=Biagini |first7=R. |last8=Bielack |first8=S. |last9=Blay |first9=J. Y. |last10=Bolle |first10=S. |last11=Bonvalot |first11=S. |last12=Boukovinas |first12=I. |last13=Bovee |first13=J. V. M. G. |last14=Boye |first14=K. |last15=Brennan |first15=B. |date=2021 |title=Soft tissue and visceral sarcomas: ESMO-EURACAN-GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up☆ |journal=Annals of Oncology|volume=32 |issue=11 |pages=1348–1365 |doi=10.1016/j.annonc.2021.07.006 |issn=1569-8041 |pmid=34303806|doi-access=free |hdl=2318/1795615 |hdl-access=free }}</ref>

== Risk factors ==
Most soft-tissue sarcomas are not associated with any known risk factors or identifiable cause. There are some exceptions:

*Studies suggest that workers who are exposed to [[chlorophenol]]s in wood preservatives and [[phenoxy herbicide]]s may have a somewhat increased risk of developing soft-tissue sarcomas, although other data sets refute this association. A small number of patients with a rare blood vessel tumor, [[angiosarcoma]] of the liver, had been exposed to [[vinyl chloride]] in their work. This substance is used in the manufacture of certain plastics, notably [[polyvinyl chloride|PVC]].<ref>{{Cite news|url=http://www.cancercenter.com/soft-tissue-sarcoma/risk-factors/|title=Soft Tissue Sarcoma Risk Factors {{!}} CTCA|work=CancerCenter.com|access-date=2017-04-07|archive-date=2017-11-01|archive-url=https://web.archive.org/web/20171101095725/http://www.cancercenter.com/soft-tissue-sarcoma/risk-factors/|url-status=dead}}</ref>
*In the early 1900s, when scientists were just discovering the potential uses of [[radiation]] to treat disease, little was known about safe dosage levels and precise methods of delivery. At that time, radiation was used to treat a variety of noncancerous medical problems, including enlargement of the tonsils, adenoids, and thymus gland. Later, researchers found that high doses of radiation caused soft-tissue sarcomas in some patients.<ref>{{Cite web |date=2023-10-31 |title=Radiation-Induced Second Malignancies: Understanding Risks and Improving Detection - AmericanHealthblog.com |url=https://americanhealthblog.com/index.php/2023/10/31/radiation-induced-second-malignancies-understanding-risks-and-improving-detection/ |access-date=2023-10-31 |language=en-GB}}</ref> Because of this risk, radiation treatment for cancer is now planned to ensure that the maximum dosage of radiation is delivered to diseased tissue while surrounding healthy tissue is protected as much as possible.<ref name=":0" />
*[[Kaposi's sarcoma|Kaposi sarcoma]], a rare cancer of the cells that line blood vessels in the skin and mucous membranes, is caused by [[human herpesvirus 8]]. Kaposi sarcoma often occurs in patients with [[AIDS|acquired immune deficiency syndrome]]. Kaposi sarcoma, however, has different characteristics from typical soft-tissue sarcomas and is treated differently.<ref>{{Cite journal |last1=Lebbe |first1=Celeste |last2=Garbe |first2=Claus |last3=Stratigos |first3=Alexander J. |last4=Harwood |first4=Catherine |last5=Peris |first5=Ketty |last6=Marmol |first6=Veronique Del |last7=Malvehy |first7=Josep |last8=Zalaudek |first8=Iris |last9=Hoeller |first9=Christoph |last10=Dummer |first10=Reinhard |last11=Forsea |first11=Ana Maria |last12=Kandolf-Sekulovic |first12=Lidija |last13=Olah |first13=Judith |last14=Arenberger |first14=Petr |last15=Bylaite-Bucinskiene |first15=Matilda |date=2019 |title=Diagnosis and treatment of Kaposi's sarcoma: European consensus-based interdisciplinary guideline (EDF/EADO/EORTC) |journal=European Journal of Cancer |volume=114 |pages=117–127 |doi=10.1016/j.ejca.2018.12.036 |issn=1879-0852 |pmid=31096150|doi-access=free }}</ref>
*In a very small fraction of cases, sarcoma may be related to a rare inherited genetic alteration of the ''[[p53|TP53]]'' gene and is known as [[Li-Fraumeni syndrome]]. Certain other [[inherited diseases]] are associated with an increased risk of developing soft-tissue sarcomas. For example, people with [[neurofibromatosis type I]] (also called von Recklinghausen disease, associated with alterations in the ''NF1 ''gene) are at an increased risk of developing soft-tissue sarcomas known as malignant peripheral nerve-sheath tumors.  Patients with inherited retinoblastoma have alterations in the ''RB1 ''gene, a tumor-suppressor gene, and are likely to develop soft-tissue sarcomas as they mature into adulthood.

== Diagnosis ==
The only reliable way to determine whether a soft-tissue tumor is benign or malignant is through a biopsy. The two methods for acquisition of tumor tissue for [[Cytopathology|cytopathological]] analysis are:
*[[Needle aspiration biopsy]], via [[Hypodermic needle|needle]] 
*Surgically, via an incision made into the tumor
A pathologist examines the tissue under a microscope. The pathologist may be the most important person in the treatment of sacomas, because they are responsible for making the proper diagnosis. Pathologists at expert sarcoma centers are invaluable in identifying the type of sarcoma responsible for a patient's symptoms. If cancer is present, the pathologist can usually determine the type of cancer and its [[Grading (tumors)|grade]]. Here, ''grade'' refers to a scale used to represent concisely the predicted growth rate of the tumor and its tendency to spread, and this is determined by the degree to which the cancer cells appear abnormal when examined under a microscope. Low-grade sarcomas, although cancerous, are defined as those that are less likely to [[metastasis]]e. High-grade sarcomas are defined as those more likely to spread to other parts of the body. For soft-tissue sarcoma, the two histological grading systems are the National Cancer Institute system and the French Federation of Cancer Centers Sarcoma Group system.<ref>{{cite journal |title=Grading of soft tissue sarcomas: from histological to molecular assessment. |year=2014 |journal=Pathology |doi=10.1097/PAT.0000000000000048 |author=Neuvill |display-authors=etal |pmid=24378389 |volume=46 |issue=2 |pages=113–20|s2cid=13436450 }}</ref><ref name="pmid17090186">{{cite journal |author=Coindre JM |title=Grading of soft tissue sarcomas: review and update |journal=Arch. Pathol. Lab. Med. |volume=130|issue=10|pages=1448–53|year=2006 |pmid=17090186 |doi=10.5858/2006-130-1448-GOSTSR|url=https://www.archivesofpathology.org/doi/full/10.1043/1543-2165%282006%29130%5B1448%3AGOSTSR%5D2.0.CO%3B2|url-access=subscription}}</ref><ref>[http://www.bmc.com.lb/PDF_Files/Grading%20of%20Bone%20&%20Soft%20Tissue%20Sarcomas.pdf Grading of Bone & Soft Tissue Sarcomas. Tawil. 2016] {{Webarchive|url=https://web.archive.org/web/20161220100759/http://bmc.com.lb/PDF_Files/Grading%20of%20Bone%20%26%20Soft%20Tissue%20Sarcomas.pdf |date=2016-12-20 }}(inc details of French system)</ref>

Soft-tissue sarcomas commonly originate in the upper body, in the shoulder or upper chest. Some symptoms are uneven posture, pain in the trapezius muscle, and [[Neck|cervical]] inflexibility [difficulty in turning the head].<ref>{{Cite journal |last1=Dyrop |first1=Heidi B. |last2=Vedsted |first2=Peter |last3=Safwat |first3=Akmal |last4=Maretty-Nielsen |first4=Katja |last5=Hansen |first5=Bjarne H. |last6=Jørgensen |first6=Peter H. |last7=Baad-Hansen |first7=Thomas |last8=Keller |first8=Johnny |date=2014 |title=Alarm symptoms of soft-tissue and bone sarcoma in patients referred to a specialist center |journal=Acta Orthopaedica |volume=85 |issue=6 |pages=657–662 |doi=10.3109/17453674.2014.957086 |issn=1745-3682 |pmc=4259033 |pmid=25175662}}</ref> The most common site to which soft-tissue sarcoma spreads is the lungs.<ref name=":1">{{Cite journal |last1=Brennan |first1=Murray F. |last2=Antonescu |first2=Cristina R. |last3=Moraco |first3=Nicole |last4=Singer |first4=Samuel |date=2014 |title=Lessons learned from the study of 10,000 patients with soft tissue sarcoma |journal=Annals of Surgery |volume=260 |issue=3 |pages=416–421; discussion 421–422 |doi=10.1097/SLA.0000000000000869 |issn=1528-1140 |pmc=4170654 |pmid=25115417}}</ref>

== Treatment ==
In general, treatment for soft-tissue sarcomas depends on the stage of the cancer. The stage of the sarcoma is based on the size and grade of the tumor, and whether the cancer has spread to the lymph nodes or other parts of the body (metastasized). Treatment options for soft-tissue sarcomas include [[surgery]], [[radiotherapy]], [[chemotherapy]], and targeted drug therapy.<ref name="STS"/>

* Surgery is the most common treatment for soft-tissue sarcomas, and usually the only way to achieve a cure. The tumor is removed leaving a safe margin of surrounding healthy tissue to decrease the chances of its recurrence.
* [[Radiation therapy]] may be used as a [[neoadjuvant therapy|neoadjuvant]] before surgery to shrink tumors, or as an [[Adjuvant therapy|adjuvant]] after surgery to kill any cancer cells that may have been left behind. In some cases, it can be used to treat tumor that cannot be surgically removed.
* [[Chemotherapy]]  may be used with radiation therapy either before or after surgery to try to shrink the tumor or kill any remaining cancer cells.  There is evidence to suggest that [[doxorubicin]] chemotherapy as an adjuvant can reduce recurrence at the original site or elsewhere in the body.<ref name="Cochrane">{{Cite journal|date=2000-10-23|title=Adjuvant chemotherapy for localised resectable soft tissue sarcoma in adults|journal=Cochrane Database of Systematic Reviews|doi=10.1002/14651858.cd001419|issn=1465-1858|pmc=8078558|author1=Sarcoma Meta-analysis Collaboration (SMAC) - see acknowledgement section for list of authors |volume=2000 |issue=4 |pages=CD001419 |pmid=10796873 }}</ref> Evidence also suggests chemotherapy can increase the length of time patients live, but this is less certain evidence. The use of chemotherapy to prevent the spread of soft-tissue sarcomas has not been proven to be effective. If the cancer has spread to other areas of the body, chemotherapy may be used to shrink tumors and reduce the pain and discomfort they cause, but is unlikely to eradicate the disease. A combination of [[docetaxel]] and [[gemcitabine]] could be an effective chemotherapy regimen in patients with advanced soft-tissue sarcoma.<ref>{{cite web |url=http://professional.cancerconsultants.com/oncology_sarcoma_cancer_news.aspx?id=36670 |title=Oncology Sarcoma Cancer News |access-date=2010-06-15 |url-status=dead |archive-url=https://web.archive.org/web/20101210025537/http://professional.cancerconsultants.com/oncology_sarcoma_cancer_news.aspx?id=36670 |archive-date=2010-12-10 }}</ref><ref>[http://theoncologist.alphamedpress.org/content/12/8/999.full Gemcitabine and Docetaxel in Metastatic Sarcoma: Past, Present, and Future. 2007](free full text)</ref>
* Outcomes are better for patients who are seen (and ideally treated) at expert sarcoma centers.<ref>{{Cite journal |last1=Blay |first1=J.-Y. |last2=Honoré |first2=C. |last3=Stoeckle |first3=E. |last4=Meeus |first4=P. |last5=Jafari |first5=M. |last6=Gouin |first6=F. |last7=Anract |first7=P. |last8=Ferron |first8=G. |last9=Rochwerger |first9=A. |last10=Ropars |first10=M. |last11=Carrere |first11=S. |last12=Marchal |first12=F. |last13=Sirveaux |first13=F. |last14=Di Marco |first14=A. |last15=Le Nail |first15=L. R. |date=2019-07-01 |title=Surgery in reference centers improves survival of sarcoma patients: a nationwide study |journal=Annals of Oncology|volume=30 |issue=7 |pages=1143–1153 |doi=10.1093/annonc/mdz124 |issn=1569-8041 |pmc=6637376 |pmid=31081028}}</ref> In the United States, these are generally found in NCI-designated cancer centers.[https://www.cancer.gov/research/infrastructure/cancer-centers]

==Research==
Soft-tissue sarcoma research requires significant effort due to its rarity; successful research requires substantial collaboration. Year by year, the medical field is learning that the various types cannot be lumped together and each sarcoma needs to be considered a different type of cancer.<ref>{{cite journal |last1=Rastogi |first1=Sameer |last2=Manasa |first2=Parisa |last3=Kalra |first3=Kaushal |display-authors=etal |date=2019 |title=Advances in soft-tissue sarcoma – There are no mistakes, only lessons<!--space omitted in original, included in PMC etc. versions--> to learn! |journal=South Asian Journal of Cancer |volume=8 |issue=4 |pages=258–259 |doi=10.4103/sajc.sajc_215_19 |pmc=6852635 |pmid=31807494 |doi-access=free }}</ref>

As a novel form of treatment used in other cancers, immunotherapy may have a role in treating soft-tissue sarcomas like alveolar soft part sarcoma and pleomorphic undifferentiated sarcoma. However, as of 2023, only alveolar soft part sarcoma has a regulatory approval for such an agent, in this case atezolizumab.<ref>{{Cite journal |last=Research |first=Center for Drug Evaluation and |date=2022-12-09 |title=FDA grants approval to atezolizumab for alveolar soft part sarcoma |url=https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-approval-atezolizumab-alveolar-soft-part-sarcoma |journal=FDA |language=en}}</ref>

=== Example of sarcoma immunology research: the Immunological Constant of Rejection ===
When the [[Immunologic Constant of Rejection|immunological constant of rejection signature (ICR)]] was retrospectively applied ICR to 1455 non-metastatic STS and searched for correlations between ICR classes and clinicopathological and biological variables; thirty-four per cent of tumors were classified as ICR1, 27% ICR2, 24% ICR3, and 15% ICR4. These classes were associated with patients’ age, pathological type, and tumor depth, and an enrichment from ICR1 to ICR4 of quantitative/qualitative scores of immune response. ICR1 class was associated with a 59% increased risk of metastatic relapse when compared with ICR2-4 class. In multivariate analysis, ICR classification remained associated with metastasis-free survival, as well as pathological type and Complexity Index in Sarcomas (CINSARC) classification, suggesting independent prognostic value.<ref name="Bertucci">{{cite journal |last1=Bertucci |first1=F |last2=Niziers |first2=V |last3=de Nonneville |first3=A |last10=Ceccarelli et al.|title=Immunologic constant of rejection signature is prognostic in soft-tissue sarcoma and refines the CINSARC signature. |journal=Journal for Immunotherapy of Cancer |date=January 2022 |volume=10 |issue=1 |pages=e003687 |doi=10.1136/jitc-2021-003687 |pmid=35017155|pmc=8753443 }}</ref>

ICR signature is independently associated with postoperative MFS in early-stage STS, independently from other prognostic features, including CINSARC. A robust prognostic clinicogenomic model integrating ICR, CINSARC, and pathological type, and suggested differential vulnerability of each prognostic group to different systemic therapies.<ref name="Bertucci"/>

== Epidemiology ==
Soft-tissue sarcomas are very uncommon cancers. They account for less than 1% of all new cancer cases each year.<ref name=":2">{{Cite journal |last1=Siegel |first1=Rebecca L. |last2=Miller |first2=Kimberly D. |last3=Wagle |first3=Nikita Sandeep |last4=Jemal |first4=Ahmedin |date=January 2023 |title=Cancer statistics, 2023 |journal=CA: A Cancer Journal for Clinicians |volume=73 |issue=1 |pages=17–48 |doi=10.3322/caac.21763 |issn=1542-4863 |pmid=36633525|doi-access=free }}</ref>

In 2023, about 14,300 new cases were diagnosed in the United States.<ref name=":2" />  Soft-tissue sarcomas are more commonly found in older patients (>50 years old), although in children and adolescents under age 20, certain histologies are common ([[rhabdomyosarcoma]], [[synovial sarcoma]]).<ref name=":1" />

Around 3,300 people were diagnosed with soft-tissue sarcoma in the UK in 2011.<ref>{{cite web|title=Soft tissue sarcoma statistics|url=http://www.cancerresearchuk.org/cancer-info/cancerstats/types/soft-tissue-sarcoma/|website=Cancer Research UK|access-date=28 October 2014}}</ref>

== Notable cases ==
* Actor [[Robert Urich]] died from [[synovial sarcoma]].<ref>{{Cite web |date=2002-04-16 |title=Robert Urich Loses Cancer Fight |url=https://www.cbsnews.com/news/robert-urich-loses-cancer-fight/ |access-date=2023-05-07 |website=[[CBS News]]}}</ref>
* Folksinger [[Kate McGarrigle]] died from [[clear-cell sarcoma]].<ref>[https://www.nytimes.com/2010/01/20/arts/music/20mcgarrigle.html "Kate McGarrigle, Canadian Singer and Songwriter, Dies at 63"]; ''[[The New York Times]],'' Jan. 20, 2010</ref>
* Actress [[Michelle Thomas]] died from [[desmoplastic small-round-cell tumor]], a rare abdominal soft-tissue sarcoma.<ref>{{Cite web |title=Celebrities With Stomach Cancer |url=https://www.webmd.com/cancer/ss/slideshow-celebrities-gastric-cancer |access-date=2023-05-07 |website=WebMD |language=en}}</ref>
* ''[[It Is Written]]'' evangelist Henry Feyerabend died from sarcoma in his leg.<ref>{{Cite web |date=2021-10-24 |title=Feyerabend, Henry Raymond (1931–2006) |url=https://encyclopedia.adventist.org/article?id=GIB7 |access-date=2023-05-07 |website=Encyclopedia of Seventh Day Adventists}}</ref>
* Video game concept artist [[Adam Adamowicz]] died from complications of a rare muscle sarcoma on February 9, 2012, at age 42.{{Citation needed|date=May 2023}}
* Professional wrestler [[Jake Roberts]] revealed he has muscle cancer.{{Citation needed|date=May 2023}}
* Professional wrestler [[Zack Ryder]] revealed he had [[synovial sarcoma]] as a teenager.<ref>{{Cite web |title=The scars of the Superstars |url=https://www.wwe.com/node/26355169/page-13 |access-date=2023-05-07 |website=WWE |language=en}}</ref>
* India's ex-finance minister [[Arun Jaitley]] died from sarcoma on August 24, 2019.<ref>{{Cite web |last=Phelamei |first=Salome |date=2019-08-24 |title=Arun Jaitley was treated for a rare type of cancer: What is soft tissue sarcoma? Symptoms, causes, treatment |url=https://www.timesnownews.com/health/article/arun-jaitley-was-treated-for-a-rare-type-of-cancer-what-is-soft-tissue-sarcoma-symptoms-causes-treatment/348940 |access-date=2023-05-07 |website=[[Times Now News]]}}</ref>
* Writer [[Rachel Caine]] died from the disease on November 1, 2020.<ref>{{Cite web |last= |date=2020-11-02 |title=In Memoriam - Rachel Caine |url=https://www.sfwa.org/2020/11/02/in-memoriam-rachel-caine/ |access-date=2023-05-07 |website=[[Science Fiction and Fantasy Writers Association]]}}</ref>
* YouTuber [[Technoblade]] died from the disease in June, 2022.<ref>{{Cite web |last=Saunders |first=Cindy |date=2022-09-28 |title=Technoblade To Be Honored by SFA with Courage Award |url=https://www.curesarcoma.org/technoblade-courage-award-at-new-york-gala/ |access-date=2023-05-07 |website=[[Sarcoma Foundation of America]]}}</ref>

== See also ==

* [[Soft tissue sarcoma in cats and dogs]]

== References ==
{{Reflist}}

== External links ==
{{Medical resources
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{{Soft tissue tumors and sarcomas}}

[[Category:Connective/soft tissue tumors and sarcomas]]
[[Category:Sarcoma]]
[[Category:Soft tissue tumor]]

[[it:Sarcoma#Sarcoma epitelioide]]