Editing World Community Grid

{{Short description|BOINC based volunteer computing project to aid scientific research}}
{{Infobox distributed computing project
| logo                    = Worldcommunitygrid.png
| logo_size               = 250px
| developer               = {{Unbulleted list | [[United Devices]] | [[IBM]] | [[Krembil Research Institute]]}}
| released                = {{start date |2004|11|16}}<ref name="WCG introduced">{{cite press release |url=http://www-03.ibm.com/industries/healthcare/us/detail/news/Y344005K66783Y35.html |title=IBM Introduces 'World Community Grid' |publisher=[[IBM]] |date=16 November 2004 |access-date=11 February 2009 |archive-date=5 September 2022 |archive-url=https://web.archive.org/web/20220905052727/https://www.ibm.com/industries/healthcare |url-status=dead }}</ref>
| latest release version  = 7.16.19
| status                  = Active
| operating system        = {{nobr|• [[Microsoft Windows]] }}<br/>{{nobr|• [[Linux]]}}<br/>{{nobr|• [[macOS]]}}<br/>{{nobr|• [[Android (operating system)|Android]]}}<br/>{{nobr|• [[Raspberry Pi OS]]}}
| platform                = [[BOINC]]
| genre                   = [[Volunteer computing]]
| performance             =  402 [[FLOPS|TFLOPS]]<ref name=STATS>{{Cite web | url=https://www.boincstats.com/stats/15/project/detail/ | title=BOINCStats | access-date=2023-06-19 | archive-date=2023-04-05 | archive-url=https://web.archive.org/web/20230405231644/https://www.boincstats.com/stats/15/project/detail | url-status=live }}</ref>
| active users            = 23,248{{r|STATS}}
| total users             = 79,354{{r|STATS}}
| active hosts            = 57,672{{r|STATS}}
| total hosts             = 5,517,865{{r|STATS}}
| website                 = {{url|1=https://www.worldcommunitygrid.org/}}
or try {{url|2=https://www.cs.toronto.edu/~juris/jlab/wcg.html}}
| motto                   = "Let your computer daydream science"
| type                    = [[Volunteer computing]] project
|screenshot=Pandemics.gif|screenshot_size=250px}}

'''World Community Grid''' ('''WCG''') is an effort to create the world's largest [[volunteer computing]] platform to perform scientific research that benefits humanity.<ref name="About Us">{{cite web
|url=http://www.worldcommunitygrid.org/about_us/viewAboutUs.do
|title=About Us
|publisher=World Community Grid
|access-date=28 July 2007
|archive-date=19 April 2022
|archive-url=https://web.archive.org/web/20220419195719/https://www.worldcommunitygrid.org/about_us/viewAboutUs.do
|url-status=live
}}</ref> Launched on November 16, 2004, with proprietary [[Grid MP]] client from [[United Devices]] and adding support for [[BOINC|Berkeley Open Infrastructure for Network Computing (BOINC)]] in 2005, World Community Grid eventually discontinued the Grid MP client and consolidated on the BOINC platform in 2008.<ref name="bbover3">{{cite web |author=bbover3 |date=2007-08-17 |title=BOINC Migration Announcement |url=http://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=15715 |access-date=2007-08-17 |publisher=World Community Grid |archive-date=2018-11-03 |archive-url=https://web.archive.org/web/20181103032930/https://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=15715 |url-status=live }}</ref> In September 2021, it was announced that IBM transferred ownership to the [[Krembil Research Institute]] of [[University Health Network]] in [[Toronto]], [[Ontario]].<ref name=":1">{{Cite web|title=World Community Grid finds a new home at Krembil Research Institute|url=https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=732|access-date=2021-09-13|website=www.worldcommunitygrid.org |archive-url=https://web.archive.org/web/20210913180104/https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=732 |archive-date=2021-09-13 |url-status=live}}</ref>

World Community Grid uses unused processing power of consumer devices (PCs, Laptops, Android Smartphones, etc.) to analyse data created by the research groups that participate in the grid. WCG projects have analysed data related to the [[human genome]], the [[human microbiome]], [[HIV]], [[dengue]], [[muscular dystrophy]], [[cancer]], [[influenza]], [[Ebola]], [[Zika virus]], [[virtual screening]], [[rice|rice crop yields]], [[green energy|clean energy]], [[water purification]] and [[Coronavirus disease 2019|COVID-19]], among other research areas.<ref name="ibm.org">{{Cite web|url=https://www.ibm.org/OpenPandemics|title=We want to stop pandemics in their tracks.|date=2020-04-01|website=IBM.org|access-date=2020-04-03|archive-date=2020-04-08|archive-url=https://web.archive.org/web/20200408055441/https://www.ibm.org/OpenPandemics|url-status=live}}</ref>

There are currently five active projects and 26 completed projects.<ref>{{Cite web|title=Research Overview|url=https://www.worldcommunitygrid.org/research/viewAllProjects.do|access-date=2021-04-17|website=www.worldcommunitygrid.org|archive-date=2022-04-18|archive-url=https://web.archive.org/web/20220418074921/https://www.worldcommunitygrid.org/research/viewAllProjects.do|url-status=live}}</ref> Several of these projects have published peer-reviewed papers based on the analysis of the data generated by WCG. These include an OpenZika project paper on the discovery of a compound (FAM 3) that inhibits the NS3 [[Helicase]] protein of the Zika virus, thus reducing viral replication by up to 86%;<ref>{{cite journal | vauthors = Silva S, Shimizu JF, Oliveira DM, Assis LR, Bittar C, Mottin M, Sousa BK, Mesquita NC, Regasini LO, Rahal P, Oliva G, Perryman AL, Ekins S, Andrade CH, Goulart LR, Sabino-Silva R, Merits A, Harris M, Jardim AC | display-authors = 6 | title = A diarylamine derived from anthranilic acid inhibits ZIKV replication | journal = Scientific Reports | volume = 9 | issue = 1 | pages = 17703 | date = November 2019 | pmid = 31776405 | pmc = 6881388 | doi = 10.1038/s41598-019-54169-z | bibcode = 2019NatSR...917703S }}</ref><ref>{{Cite web|url=https://www.worldcommunitygrid.org/about_us/displayNews.do|title=World Community Grid - News|access-date=2020-03-17|archive-date=2020-03-23|archive-url=https://web.archive.org/web/20200323051304/https://www.worldcommunitygrid.org/about_us/displayNews.do|url-status=live}}</ref> a FightAIDS@home paper on the discovery of new vulnerabilities on the HIV-1 [[Capsid|Capsid protein]] which may allow for a new drug target;<ref>{{cite journal | vauthors = Craveur P, Gres AT, Kirby KA, Liu D, Hammond JA, Deng Y, Forli S, Goodsell DS, Williamson JR, Sarafianos SG, Olson AJ | display-authors = 6 | title = Novel Intersubunit Interaction Critical for HIV-1 Core Assembly Defines a Potentially Targetable Inhibitor Binding Pocket | journal = mBio | volume = 10 | issue = 2 | date = March 2019 | pmid = 30862755 | doi = 10.1128/mBio.02858-18 |pmc=6414707 | doi-access = free }}</ref><ref>{{Cite web|title=FightAIDS@Home – Phase 1 researchers identified new potential targets for antivirals|url=https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=629|access-date=2021-04-17|website=www.worldcommunitygrid.org}}</ref> and a FightAIDS@home paper on new computational drug discovery techniques for more refined and accurate results.<ref>{{cite journal | vauthors = Xia J, Flynn W, Gallicchio E, Uplinger K, Armstrong JD, Forli S, Olson AJ, Levy RM | display-authors = 6 | title = Massive-Scale Binding Free Energy Simulations of HIV Integrase Complexes Using Asynchronous Replica Exchange Framework Implemented on the IBM WCG Distributed Network | journal = Journal of Chemical Information and Modeling | volume = 59 | issue = 4 | pages = 1382–1397 | date = April 2019 | pmid = 30758197 | pmc = 6496938 | doi = 10.1021/acs.jcim.8b00817 }}</ref><ref>{{Cite web|title=FightAIDS@Home Team's New Simulation Technique Published in Industry Journal|url=https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=593|access-date=2021-04-17|website=www.worldcommunitygrid.org|archive-date=2021-04-17|archive-url=https://web.archive.org/web/20210417212628/https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=593|url-status=live}}</ref>

==History==
In 2003, [[IBM]] and other research participants sponsored the ''Smallpox Research Grid Project'' to accelerate the discovery of a cure for [[smallpox]].<ref>[http://www.computerweekly.com/Articles/2003/02/06/192324/IBM-builds-grid-for-smallpox-research.htm "IBM builds grid for smallpox research"] {{Webarchive|url=https://web.archive.org/web/20200126183214/http://www.computerweekly.com/Articles/2003/02/06/192324/IBM-builds-grid-for-smallpox-research.htm |date=2020-01-26 }}. ComputerWeekly.com. 2003-02-06. Retrieved 2014-04-28.</ref> The smallpox study used a massive distributed computing grid to analyse compounds' effectiveness against smallpox.<ref name="Smallpox">{{cite news
|url=http://news.bbc.co.uk/1/hi/health/2724833.stm
|title=Computers enlisted for bioterror fight
|date=5 February 2003
|publisher=BBC
|access-date=24 November 2008
|archive-date=5 November 2021
|archive-url=https://web.archive.org/web/20211105100639/http://news.bbc.co.uk/1/hi/health/2724833.stm
|url-status=live
}}</ref> The project allowed scientists to screen 35 million potential drug molecules against several smallpox proteins to identify good candidates for developing into smallpox treatments. In the first 72 hours, 100,000 results were returned. By the end of the project, 44 strong treatment candidates had been identified.<ref name="Smallpox results">{{cite journal | vauthors = Clery D | title = Computing. IBM offers free number crunching for humanitarian research projects | journal = Science | volume = 308 | issue = 5723 | pages = 773 | date = May 2005 | pmid = 15879179 | doi = 10.1126/science.308.5723.773a | s2cid = 45713783 }}</ref> Based on the success of the Smallpox study, IBM announced the creation of World Community Grid on November 16, 2004, with the goal of creating a technical environment where other humanitarian research could be processed.<ref name="WCG introduced"/><ref name="Smallpox"/>

World Community Grid initially only supported Windows, using the proprietary [[Grid MP]] software from [[United Devices]] which powered the [[grid.org]] distributed computing projects. Demand for Linux support led to the addition in November 2005 of open source [[Berkeley Open Infrastructure for Network Computing|Berkeley Open Infrastructure for Network Computing (BOINC)]] software which powers projects such as [[Seti@home|SETI@home]] and [[Climateprediction]].<ref>{{cite web
|url=http://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=4224#33880
|title=Linux is here!!!
|author=knreed
|publisher=World Community Grid
|date=31 October 2005
|access-date=30 July 2007
|archive-date=8 September 2014
|archive-url=https://web.archive.org/web/20140908013840/http://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=4224#33880
|url-status=live
}}</ref> [[macOS|Mac OS]] and [[Linux]] support was added since the introduction of BOINC.<ref name="System Requirements">{{cite web |title=System Requirements |url=http://www.worldcommunitygrid.org/help/viewTopic.do?shortName=minimumreq |access-date=3 November 2014 |work=Help |publisher=World Community Grid |archive-date=29 December 2014 |archive-url=https://web.archive.org/web/20141229042852/http://www.worldcommunitygrid.org/help/viewTopic.do?shortName=minimumreq |url-status=live }}</ref> In 2007, the World Community Grid migrated from Grid MP to BOINC for all of its supported platforms.<ref>{{cite web|url=http://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=15715|title=World Community Grid - View Thread - BOINC Migration Announcement|work=worldcommunitygrid.org|access-date=2007-08-18|archive-date=2018-11-03|archive-url=https://web.archive.org/web/20181103032930/https://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=15715|url-status=live}}</ref>

In September 2021, IBM announced that it had transferred ownership of the World Community Grid to the [[Krembil Research Institute]].<ref>{{Cite web |last=Geddes |first=Kevin |date=2021-09-13 |title=Community-based supercomputer coming to Krembil Research Institute |url=https://uhnfoundation.ca/stories/community-based-supercomputer-coming-to-krembil-research-institute/ |access-date=2024-08-27 |website=UHN Foundation |language=en-US}}</ref>

===Scale of the project===
As of {{#time: F j, Y | 2023-01-08}}, World Community Grid had over {{formatnum:23000}} active user accounts, with over {{formatnum:57000}} active devices.{{r|STATS}} Over the course of the project, more than {{formatnum:2000000}} cumulative years of computing time have been donated, and over {{formatnum:6000000000}} work units have been completed.<ref name="Global Statistics">{{cite web|url=https://www.worldcommunitygrid.org/stat/viewGlobal.do|title=Global Statistics|publisher=World Community Grid|access-date=2023-06-19|archive-date=2023-05-05|archive-url=https://web.archive.org/web/20230505195248/https://www.worldcommunitygrid.org/stat/viewGlobal.do|url-status=live}}</ref>

==Operation==
[[File:BOINC in system tray.png|frame|The World Community Grid client software works in the background, showing itself as a small icon in the computer's [[system tray]]. When the [[BOINC]] client is used, as in this example, the icon is yellow and blue.]]
[[File:WCG on BOINC.png|thumb|250px|The client software's status window, displaying information about the work currently being done in the background. This particular computer is 95.6% complete with its current workunit. When it reaches 100%, it will start on a new workunit and the results of the previous workunit will be transmitted back to WCG.]]
The World Community Grid software uses the unused computing time of [[Internet]]-connected devices to perform research calculations.<ref name="Weiss">{{cite news |url=http://www.computerworld.com/hardwaretopics/hardware/gridcomputing/story/0,10801,97577,00.html |title='World Community Grid' seeks to harness unused computers |vauthors=Weiss T |publisher=[[Computerworld]] |date=2004-11-17 |access-date=2007-07-28 |archive-date=2007-08-15 |archive-url=https://web.archive.org/web/20070815122553/http://www.computerworld.com/hardwaretopics/hardware/gridcomputing/story/0,10801,97577,00.html |url-status=live }}</ref> Users install WCG client software onto their devices. This software works in the background, using spare system resources to process work for WCG.<ref name="Weiss"/><ref name="Privacy Policy">{{cite web |url=http://www.worldcommunitygrid.org/viewMemberPolicy.do |title=Member Policy |work=Privacy and Security |publisher=World Community Grid |access-date=2007-07-28 |archive-date=2007-08-10 |archive-url=https://web.archive.org/web/20070810071318/http://www.worldcommunitygrid.org/viewMemberPolicy.do |url-status=live }}</ref> When a piece of work or ''workunit'' is completed, the client software sends it back to WCG over the Internet and downloads a new workunit.<ref name="About Us"/><ref>{{cite web |url=http://www.worldcommunitygrid.org/help/viewTopic.do?shortName=results#29 |title=Returning Results: What is a Work Unit? |work=Help |publisher=World Community Grid |access-date=2007-08-05 |archive-date=2007-07-14 |archive-url=https://web.archive.org/web/20070714073132/http://www.worldcommunitygrid.org/help/viewTopic.do?shortName=results#29 |url-status=live }}</ref> To ensure accuracy, the WCG servers send out multiple copies of each workunit.<ref>{{cite web |url=http://www.worldcommunitygrid.org/help/viewTopic.do?shortName=install#62 |title=Installing the Windows Agent: If I re-install the software, will the work that I am doing be lost forever? |work=Help |publisher=World Community Grid |access-date=2007-08-05 |archive-date=2007-07-14 |archive-url=https://web.archive.org/web/20070714074133/http://www.worldcommunitygrid.org/help/viewTopic.do?shortName=install#62 |url-status=live }}</ref> Then, when the results are received, they are collected and validated against each other.<ref>{{cite web |url=http://www.worldcommunitygrid.org/help/viewTopic.do?shortName=points#174 |title=Points: What is validation? |work=Help |publisher=World Community Grid |access-date=2007-07-28 |archive-date=2007-08-10 |archive-url=https://web.archive.org/web/20070810070758/http://www.worldcommunitygrid.org/help/viewTopic.do?shortName=points#174 |url-status=live }}</ref>

World Community Grid offers multiple humanitarian projects under a single umbrella.
Users are included in a subset of projects by default, but may opt out of projects as they choose.<ref>{{cite web
|url=http://www.worldcommunitygrid.org/help/viewTopic.do?shortName=start#203
|title=Getting Started: I'm using the BOINC agent, how do I choose which project my computer processes work for?
|work=Help
|publisher=World Community Grid
|access-date=2014-09-26
|archive-date=2015-02-19
|archive-url=https://web.archive.org/web/20150219202156/http://www.worldcommunitygrid.org/help/viewTopic.do?shortName=start#203
|url-status=live
}}</ref>

Even though WCG makes use of open source client software, the actual applications that perform the scientific calculations may not be. However, several of the science applications are available under a free license, although the source is not available directly from WCG.<ref>{{cite web
|url=http://www.worldcommunitygrid.org/help/viewTopic.do?shortName=wcgagent#215
|title=Agent: I have a platform that isn't supported by World Community Grid. Could I receive the code and compile it myself?
|work=Help
|publisher=World Community Grid
|access-date=2007-08-05
|archive-date=2007-07-14
|archive-url=https://web.archive.org/web/20070714073307/http://www.worldcommunitygrid.org/help/viewTopic.do?shortName=wcgagent#215
|url-status=live
}}</ref>

===Potential problems===
[[File:BOINC running-Task mgr CPU usage history demo-en-1.png|right|thumb|250px|The picture shows particular two CPU usage history (under [[Hyper-threading]]) when [[BOINC]] client software is processing two tasks on each CPU under [[Microsoft Windows]] XP SP2. CPU usage history indicates almost 0% to 100% swing with peak to peak of 3 seconds [[Interval (time)|interval]], when view +update speed set to high, at first half recording period. The rest of half period of history is set to update speed normal, and upper CPU usage history indicates slightly more than 60% and lower CPU usage history show 35% approx. in average.]]
The World Community Grid software increases [[CPU]] usage by consuming unused processing time; in the late 1990s and early 2000s, such calculations were meant to reduce "wasted" CPU cycles.<ref>{{Cite web | url=http://www.sharewarejunkies.com/9zwd11/setihome.htm | title=SETI@Home | access-date=2017-07-28 | archive-date=2019-03-03 | archive-url=https://web.archive.org/web/20190303222604/http://www.sharewarejunkies.com/9zwd11/setihome.htm | url-status=live }}</ref> With modern CPUs, where [[dynamic frequency scaling]] is prevalent, increased usage makes the processor run at higher frequency,<ref>Although on [[Linux]] systems the [https://www.kernel.org/doc/Documentation/cpu-freq/governors.txt CPUfreq frequency scaling governor can be configured otherwise] {{Webarchive|url=https://web.archive.org/web/20170607174541/https://www.kernel.org/doc/Documentation/cpu-freq/governors.txt |date=2017-06-07 }} with the parameter ignore_nice_load.</ref> increasing power usage and heating counter to [[power management]]. Additionally, because of an increasing focus on power performance,<ref>{{Cite web | url=https://www.cpubenchmark.net/power_performance.html | title=PassMark CPU TDP Chart - Performance / Power of available CPUs | access-date=2017-07-28 | archive-date=2017-07-29 | archive-url=https://web.archive.org/web/20170729022431/https://www.cpubenchmark.net/power_performance.html | url-status=live }}</ref> or [[performance per watt]], connecting old/inefficient computers to the grid will increase the total/average power required to complete the same calculations.

The [[BOINC]] client avoids slowing the computer by using a variety of limits that suspend computation when there are insufficient free resources. Unlike other BOINC projects, World Community Grid set the BOINC defaults conservatively, making the chances of computer damage extremely small. The default CPU throttle is 60%. The throttle is coarse-grained; for example, if usage is set to 60% it will work at 100% for 3 seconds, then at 0% for 2 seconds, resulting in an average decrease of processor use.<ref>{{cite web
|url=http://www.worldcommunitygrid.org/help/viewTopic.do?shortName=cpuuse#33
|title=CPU Usage: Why does my PC show high CPU use?
|work=Help
|publisher=World Community Grid
|access-date=2007-08-05
|archive-date=2007-07-14
|archive-url=https://web.archive.org/web/20070714084446/http://www.worldcommunitygrid.org/help/viewTopic.do?shortName=cpuuse#33
|url-status=live
}}</ref>

An add-on program for Windows computers – [http://efmer.eu/boinc/ TThrottle] – can solve the problem of overheating by directly limiting the BOINC project's use of the host computer. It does this by measuring the CPU and/or the GPU temperature and adjusts the run time accordingly. It also uses a shorter switching time of less than one second, resulting in less temperature change during switching.{{citation needed|date=May 2017}}

==Statistics and competition==
The contributions of each user are recorded and user contribution statistics are publicly available.<ref name="Global Statistics"/> Due to the fact that the processing time of each workunit varies from computer to computer, depending on the difficulty of the workunit, the speed of the computer, and the amount of idle resources available, contributions are usually measured in terms of ''points''. Points are awarded for each workunit depending on the effort required to process it.<ref>{{cite web
|url=http://www.worldcommunitygrid.org/help/viewTopic.do?shortName=points#27
|title=Points: What are points?
|work=Help
|publisher=World Community Grid
|access-date=2007-07-28
|archive-date=2007-08-10
|archive-url=https://web.archive.org/web/20070810070758/http://www.worldcommunitygrid.org/help/viewTopic.do?shortName=points#27
|url-status=live
}}</ref>

Upon completing a workunit, the [[BOINC]] client will request the number of points it thinks it deserves based on software [[Benchmark (computing)|benchmark]]s (''see [[BOINC Credit System#Cobblestones]]''). Since multiple computers process the same workunit to ensure accuracy, the World Community Grid servers can look at the points claimed by each of those computers. The WCG servers disregard statistical outliers, average the remaining values and award the resulting number of points to each computer.<ref>{{cite web
|url=http://www.worldcommunitygrid.org/help/viewTopic.do?shortName=points#177
|title=Points: How are points calculated for the BOINC agent?
|work=Help
|publisher=World Community Grid
|access-date=2007-08-05
|archive-date=2007-08-10
|archive-url=https://web.archive.org/web/20070810070758/http://www.worldcommunitygrid.org/help/viewTopic.do?shortName=points#177
|url-status=live
}}</ref><ref>{{cite web
|url=http://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=9545
|title=BOINC Points
|author=knreed
|publisher=World Community Grid
|date=2006-11-02
|access-date=2007-07-28
|archive-date=2015-11-07
|archive-url=https://web.archive.org/web/20151107061230/http://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=9545
|url-status=live
}}</ref>

Within the grid, users may join teams that have been created by organizations, groups, or individuals. Teams allow for a heightened sense of community identity and can also inspire competition. As teams compete against each other, more work is done for the grid overall.<ref>{{cite web
|url=http://www.worldcommunitygrid.org/help/viewTopic.do?shortName=teams
|title=Teams
|work=Help
|publisher=World Community Grid
|access-date=2007-07-28
|archive-date=2007-07-17
|archive-url=https://web.archive.org/web/20070717154301/http://www.worldcommunitygrid.org/help/viewTopic.do?shortName=teams
|url-status=live
}}</ref>

==Outreach==
World Community Grid recognizes companies and organizations as ''partners'' if they promote WCG within their company or organization. As of April 2021, WCG had 452 partners.<ref>{{cite web|url=http://www.worldcommunitygrid.org/about_us/viewOurPartners.do|title=About Us - Our Partners|publisher=World Community Grid|access-date=2018-03-04|archive-date=2010-02-08|archive-url=https://web.archive.org/web/20100208234221/http://www.worldcommunitygrid.org/about_us/viewOurPartners.do|url-status=live}}</ref>

Also, as part of its commitment to improving human health and welfare, the results of all computations completed on World Community Grid are released into the public domain and made available to the scientific community.<ref name="About Us"/>

==Scientific results==
Since its launch, more than thirty projects have run in the World Community Grid. Some of the results include:

* In February 2014, the '''[[Help Fight Childhood Cancer]]''' project scientists announced the discovery of 7 compounds that destroy [[neuroblastoma]] cancer cells without any apparent side effects.<ref>{{cite web | title = Breakthrough in the fight against childhood cancer | date = 20 February 2014 | url = http://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=342 | work = worldcommunitygrid.org | access-date = 18 January 2015 | archive-date = 21 December 2014 | archive-url = https://web.archive.org/web/20141221132757/http://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=342 | url-status = live }}</ref> This discovery, made with the support of the WCG volunteers, is a positive step towards a new treatment. The project has announced that it is seeking a collaboration with a pharmaceutical company in order to develop the compounds into treatments. Given the success of the project, the scientists have stated that they are already planning a follow-up project which will focus on other [[pediatric cancer]]s, possibly in collaboration with a newly formed Pan-Asian oncology group, of which they are a founding member.<ref>{{cite web|url=http://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=365|title=Advancing and expanding Help Fight Childhood Cancer research|date=2 July 2014|vauthors=Nakagawara A|work=worldcommunitygrid.org|access-date=24 October 2014|archive-date=24 October 2014|archive-url=https://web.archive.org/web/20141024232845/http://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=365|url-status=live}}</ref> 
*As of July 2012, the '''[[Human Proteome Folding Project]]''' has published several papers using data from WCG.<ref>{{Cite web|last=Grid|first=World Community|date=2021-05-01|title=World Community Grid - HPF Research Papers|url=https://www.worldcommunitygrid.org/about_us/displayNews.do?filterCategory=3_10&filterTags=14&sortBy=&pageNum=1|url-status=live|access-date=2021-05-01|website=World Community Grid|archive-date=2021-05-01|archive-url=https://web.archive.org/web/20210501114256/https://www.worldcommunitygrid.org/about_us/displayNews.do?filterCategory=3_10&filterTags=14&sortBy=&pageNum=1}}</ref> These include a paper on validation methods and a new database of protein structure and function predictions;<ref>{{Cite journal|last1=Drew|first1=Kevin|last2=Winters|first2=Patrick|last3=Butterfoss|first3=Glenn L.|last4=Berstis|first4=Viktors|last5=Uplinger|first5=Keith|last6=Armstrong|first6=Jonathan|last7=Riffle|first7=Michael|last8=Schweighofer|first8=Erik|last9=Bovermann|first9=Bill|last10=Goodlett|first10=David R.|last11=Davis|first11=Trisha N.|date=2011-11-01|title=The Proteome Folding Project: Proteome-scale prediction of structure and function|journal=Genome Research|language=en|volume=21|issue=11|pages=1981–1994| pmc=3205581|doi=10.1101/gr.121475.111|issn=1088-9051|pmid=21824995|doi-access=free}}</ref> a paper on the identification of proteins that regulate human processes;<ref>{{Cite journal|last1=Baltz|first1=Alexander G.|last2=Munschauer|first2=Mathias|last3=Schwanhäusser|first3=Björn|last4=Vasile|first4=Alexandra|last5=Murakawa|first5=Yasuhiro|last6=Schueler|first6=Markus|last7=Youngs|first7=Noah|last8=Penfold-Brown|first8=Duncan|last9=Drew|first9=Kevin|last10=Milek|first10=Miha|last11=Wyler|first11=Emanuel|date=2012-06-08|title=The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts|journal=Molecular Cell|language=English|volume=46|issue=5|pages=674–690|doi=10.1016/j.molcel.2012.05.021|issn=1097-2765|pmid=22681889|doi-access=free}}</ref> a paper on the analysis of the genomes from five plant families and their proteomes, for which WCG was used in the creation of over 29,000 protein structures;<ref>{{Cite journal|last1=Pentony|first1=M. M.|last2=Winters|first2=P.|last3=Penfold-Brown|first3=D.|last4=Drew|first4=K.|last5=Narechania|first5=A.|last6=DeSalle|first6=R.|last7=Bonneau|first7=R.|last8=Purugganan|first8=M. D.|date=2012|title=The Plant Proteome Folding Project: Structure and Positive Selection in Plant Protein Families|url= |journal=Genome Biology and Evolution|volume=4|issue=3|pages=360–371|doi=10.1093/gbe/evs015|issn=1759-6653|pmc=3318447|pmid=22345424}}</ref> a paper on the proteome of ''[[Saccharomyces cerevisiae]]''.<ref>{{Cite journal|last1=Malmström|first1=Lars|last2=Riffle|first2=Michael|last3=Strauss|first3=Charlie E. M.|last4=Chivian|first4=Dylan|last5=Davis|first5=Trisha N.|last6=Bonneau|first6=Richard|last7=Baker|first7=David|date=2007-03-20|title=Superfamily Assignments for the Yeast Proteome through Integration of Structure Prediction with the Gene Ontology|journal=PLOS Biology|language=en|volume=5|issue=4|pages=e76|doi=10.1371/journal.pbio.0050076|issn=1545-7885|pmc=1828141|pmid=17373854 |doi-access=free }}</ref>
*The '''GO Fight Against Malaria''' project reported the discovery of several molecules that are effective against [[Malaria]] and Drug-Resistant [[Tuberculosis]] (including TDR-TB, for which there is no treatment available). The project also tested for new molecules against [[MRSA]], [[Filariasis]] and [[Bubonic Plague]]. Laboratory testing continues in order to turn those molecules into possible treatments. GFAM was also the first project ever to perform a billion different docking calculations.<ref>{{cite web|url=http://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=373|title=GO Fight Against Malaria update: promising early findings for malaria & drug-resistant tuberculosis|date=14 July 2014|vauthors=Perryman AL|work=worldcommunitygrid.org|access-date=24 October 2014|archive-date=24 October 2014|archive-url=https://web.archive.org/web/20141024232650/http://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=373|url-status=live}}</ref> A paper was published in January 2015,<ref name=":0">{{Cite web|url=http://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=433|title=Post grid calculations continue to yield progress and inspire new methods against deadly diseases|website=www.worldcommunitygrid.org|language=en-US|access-date=2018-03-04|archive-date=2019-01-30|archive-url=https://web.archive.org/web/20190130060327/https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=433|url-status=live}}</ref><ref>{{cite journal | vauthors = Perryman AL, Yu W, Wang X, Ekins S, Forli S, Li SG, Freundlich JS, Tonge PJ, Olson AJ | display-authors = 6 | title = A virtual screen discovers novel, fragment-sized inhibitors of Mycobacterium tuberculosis InhA | journal = Journal of Chemical Information and Modeling | volume = 55 | issue = 3 | pages = 645–59 | date = March 2015 | pmid = 25636146 | pmc = 4386068 | doi = 10.1021/ci500672v }}</ref> with two more pending submission. In June 2015, the project reported that of the two "hits" discovered against a drug-resistant tuberculosis strain, several "analogs" have been synthesized, the best one of which inhibits the growth of ''[[Mycobacterium tuberculosis]]'' and is relatively non-toxic to mammalian cells.<ref name=":0" /> Lack of funding prevented further research into the data.
*The '''[[Discovering Dengue Drugs - Together]]''' project scientists reported the discovery of several new Dengue protease inhibitors, most of which also inhibit the [[West Nile virus]] protease. A handful of these have already entered "crucial pre-clinical pharmacokinetic and efficacy studies". In November 2014, an update reported that the scientists have a drug lead that disables a key enzyme that allows the Dengue virus to replicate. It has also shown the same behaviour in other flaviviruses, such as the West Nile virus. No negative side effects such as toxicity, carcinogenicity or mutagenicity have been observed, making this drug lead a very strong antiviral drug candidate for these viruses. The scientists are now working to synthesize variants of the molecule to improve its activity and enter planned pre-clinical and clinical trials.<ref>{{Cite web|url = https://secure.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=397|title = Decade of Discovery: A new drug lead to combat dengue fever|access-date = 2014-11-12|archive-date = 2014-11-12|archive-url = https://web.archive.org/web/20141112184053/https://secure.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=397|url-status = live}}</ref> However, in an October 2018 update, the research team reported that none of their current designs had produced a highly potent dengue protease inhibitor that could be tested ''in vivo''.<ref>{{Cite web|title=Discovering Dengue Drugs - Together Takes a New Approach to Data Analysis|url=https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=541|access-date=2021-05-01|website=www.worldcommunitygrid.org|archive-date=2021-07-16|archive-url=https://web.archive.org/web/20210716000430/https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=541|url-status=live}}</ref>
*In June 2013, the '''[[Clean Energy Project]]''' published a database of over 2.3 million organic molecules which have had their properties characterized. Of these, 35,000 molecules have shown the potential to double the efficiency over organic solar cells currently being produced. Before this initiative, scientists knew of just a handful of carbon-based materials that were able to convert sunlight into electricity efficiently.<ref>{{cite web|url=https://secure.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=387|title=Decade of discovery: doubling carbon-based solar cell efficiency|work=worldcommunitygrid.org|access-date=2014-10-24|archive-date=2014-10-24|archive-url=https://web.archive.org/web/20141024232651/https://secure.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=387|url-status=live}}</ref><ref>{{citation |url=https://secure.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=307 |publisher=worldcommunitygrid.org |title=Harvard publishes World Community Grid data, rating millions of compounds for use in solar cells |date=24 June 2013 |access-date=24 October 2014 |archive-date=10 October 2014 |archive-url=https://web.archive.org/web/20141010034816/https://secure.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=307 |url-status=live }}</ref>
*In February 2010, the '''[[FightAIDS@Home]]''' project scientists announced that they have found two compounds which make a potentially new class of AIDS-fighting drugs possible. The compounds attach to the virus at newly discovered binding sites, and thus can be used to "enhance existing therapies, treat drug-resistant strains of the disease, and slow the evolution of drug resistance in the virus."<ref>{{cite web|url=http://www.scripps.edu/newsandviews/e_20100208/hiv.html|title=TSRI - News & Views, Scientists Find Two Compounds that Lay the Foundation for a New Class of AIDS Drug|work=scripps.edu|access-date=2014-10-25|archive-date=2014-08-12|archive-url=https://web.archive.org/web/20140812024154/http://www.scripps.edu/newsandviews/e_20100208/hiv.html|url-status=live}}</ref><ref>{{cite web|url=https://secure.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=122|title=Two Compounds Discovered that Pave the Way for New Class of AIDS Drug|date=2 March 2010|work=worldcommunitygrid.org|access-date=25 October 2014|archive-date=25 October 2014|archive-url=https://web.archive.org/web/20141025144912/https://secure.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=122|url-status=live}}</ref>
*In July 2015, the '''Drug Search for Leishmaniasis''' project announced it had tested the top 10 compounds with highest predicted efficiency out of over 100 identified via WCG workunits. Of those 10, 4 showed "positive results" in ''in vitro'' testing, with one showing "an exceptionally promising result".<ref>{{Cite web|url=http://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=435|title=Exceptional early results in the fight against Leishmaniasis|website=www.worldcommunitygrid.org|language=en-US|access-date=2018-03-04|archive-date=2019-01-30|archive-url=https://web.archive.org/web/20190130054933/https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=435|url-status=live}}</ref> In August 2017, ''in vivo'' testing of the 4 compounds on hamsters showed favourable results, with one compound inducing "an almost complete curing of the lesions in two out of five hamsters."<ref>{{Cite web|url=https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=534|title=Potential New Treatments for Leishmaniasis Tested in Lab|website=www.worldcommunitygrid.org|language=en-US|access-date=2018-03-04|archive-date=2019-01-30|archive-url=https://web.archive.org/web/20190130043435/https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=534|url-status=live}}</ref> However, in a March 2018 update, the research team announced none of the 10 tested compounds had sufficient anti-leishmaniasis activity.<ref>{{Cite web|title=Drug Search for Leishmaniasis Project Continues Quest for Better Treatments|url=https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=556|access-date=2021-05-01|website=www.worldcommunitygrid.org|archive-date=2021-05-01|archive-url=https://web.archive.org/web/20210501114258/https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=556|url-status=live}}</ref>
*In July 2015, the '''Computing for Clean Water''' project announced that a paper had been published in the [[Nature Nanotechnology]] journal describing a new type of water filter efficiently utilising nanotubes. "[The] nanotubes are made of single-atom-thick sheets of carbon atoms, called [[graphene]], rolled up into tiny tubes, with diameters of just a few nanometers - one ten-thousandth the diameter of a human hair. The size of the tubes allows water molecules to pass through, but blocks larger pathogens and contaminants, purifying the water." By running simulations on WCG, the scientists discovered that certain kinds of natural vibrations called [[phonon]]s, under specific conditions, can lead to more than 300% increased flow of water through the nanotubes, compared to previous theoretical predictions.<ref>{{Cite web|url=https://secure.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=436|title=Enhancing the potential for nanotechnology to improve access to clean water for millions|website=secure.worldcommunitygrid.org|language=en-US|access-date=2018-03-04|archive-date=2016-12-03|archive-url=https://web.archive.org/web/20161203080307/https://secure.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=436|url-status=live}}</ref>
*In April 2015, the '''Say No To Schistosoma project''' scientists reported that subsequent analysis had been performed, and the three most promising candidate substances had been identified for ''in vitro'' testing.<ref name="secure.worldcommunitygrid.org">{{citation |url=https://secure.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=427 |title=Turning virtual results into real-world treatments for schistosoma |access-date=14 July 2015 |archive-date=14 July 2015 |archive-url=https://web.archive.org/web/20150714205758/https://secure.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=427 |url-status=live }}</ref>
*In March 2019, '''[[FightAIDS@Home]]''' researchers published a paper describing a "Novel Intersubunit Interaction Critical for HIV-1 Core Assembly" that "defines a Potentially Targetable Inhibitor Binding Pocket". Using World Community Grid, more than 1.6 million compounds were used to target 20 conformations of this pocket. Preliminary results suggest it to be a plausible binding site for antiviral compounds. Further analysis of these compounds are the subject of an independent study.<ref>{{cite journal | vauthors = Craveur P, Gres AT, Kirby KA, Liu D, Hammond JA, Deng Y, Forli S, Goodsell DS, Williamson JR, Sarafianos SG, Olson AJ | display-authors = 6 | title = Novel Intersubunit Interaction Critical for HIV-1 Core Assembly Defines a Potentially Targetable Inhibitor Binding Pocket | journal = mBio | volume = 10 | issue = 2 | date = March 2019 | pmid = 30862755 | doi = 10.1128/mBio.02858-18| pmc=6414707  }}</ref>

==Active subprojects==

=== OpenPandemics - COVID-19 ===
On April 1, 2020, IBM announced '''OpenPandemics - COVID-19'''. The project aims to identify possible treatments for the [[Severe acute respiratory syndrome coronavirus 2]] (SARS-CoV-2) which is responsible for the [[COVID-19 pandemic]]. WCG will partner with [[Scripps Research]], with whom it has partnered in the past, notably in [[FightAIDS@Home]] projects. The project runs on CPUs and GPUs and will also serve to create a "fast-response, open source tool that will help all scientists quickly search for treatments for future pandemics."<ref name="ibm.org"/><ref>{{Cite web|url=https://www.worldcommunitygrid.org/forums/wcg/viewthread_thread,42232|title=Coming Soon: OpenPandemics|date=2020-04-01|website=World Community Grid|access-date=2020-04-03|archive-date=2020-07-19|archive-url=https://web.archive.org/web/20200719061916/https://www.worldcommunitygrid.org/forums/wcg/viewthread_thread,42232|url-status=live}}</ref><ref>{{Cite web|url=https://www.worldcommunitygrid.org/forums/wcg/viewthread_thread,42230|title=Questions about science and technology for OpenPandemics (launch TBA)|date=2020-04-01|website=World Community Grid|access-date=2020-04-03|archive-date=2022-09-05|archive-url=https://web.archive.org/web/20220905052754/https://www.worldcommunitygrid.org/forums/wcg/viewthread_thread,42230|url-status=live}}</ref><ref>{{Cite web|url=https://www.worldcommunitygrid.org/forums/wcg/viewthread_thread,42231|title=Questions about work units and badges for OpenPandemics (launch TBA)|date=2020-04-01|website=World Community Grid|access-date=2020-04-03|archive-date=2020-07-19|archive-url=https://web.archive.org/web/20200719013838/https://www.worldcommunitygrid.org/forums/wcg/viewthread_thread,42231|url-status=live}}</ref>

The project launched on May 14, 2020.<ref>{{Cite web|title=Help Stop COVID-19 and Future Pandemics in Their Tracks|url=https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=624|date=2020-05-14|website=World Community Grid|access-date=2020-05-14|archive-date=2020-05-14|archive-url=https://web.archive.org/web/20200514172639/https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=624|url-status=live}}</ref>

===Mapping Cancer Markers===
'''Mapping Cancer Markers''' (launched November 8, 2013). The project aims to identify the markers associated with various types of cancer, and is analyzing millions of data points collected from thousands of healthy and cancerous patient tissue samples. These include tissues with lung, ovarian, prostate, pancreatic and breast cancers. By comparing these different data points, researchers aim to identify patterns of markers for different cancers and correlate them with different outcomes, including responsiveness to various treatment options. The project is focusing on 4 types of cancer, with the first focus being on lung cancer, and will move on to ovarian cancer, prostate cancer and sarcoma.<ref>{{cite web|url=https://secure.worldcommunitygrid.org/research/mcm1/overview.do|title=World Community Grid - Research - Mapping Cancer Markers|work=worldcommunitygrid.org|access-date=2013-11-16|archive-date=2014-04-16|archive-url=https://web.archive.org/web/20140416191925/https://secure.worldcommunitygrid.org/research/mcm1/overview.do|url-status=live}}</ref><ref>{{cite web|url=https://secure.worldcommunitygrid.org/forums/wcg/viewthread_thread,36146_offset,0#445500|title=World Community Grid - View Thread - MCM1 Update|work=worldcommunitygrid.org|access-date=2014-04-15|archive-date=2022-09-05|archive-url=https://web.archive.org/web/20220905052734/https://www.worldcommunitygrid.org/forums/wcg/viewthread_thread,36146_offset,0#445500|url-status=live}}</ref>

=== Africa Rainfall Project ===
The '''Africa Rainfall Project''' (launched October 2019) will use the computing power of World Community Grid, data from The Weather Company, and other data to improve rainfall modelling, which can help farmers in sub-Saharan Africa successfully raise their crops.<ref>“[https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=608 Announcing the Africa Rainfall Project] {{Webarchive|url=https://web.archive.org/web/20191203105739/https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=608 |date=2019-12-03 }}”, World Community Grid. Retrieved, 30 Oct 2019.</ref>
The amount of RAM that can be involved in calculations is from 1 to 16 gigabytes.<ref>{{cite web | url=https://www.reddit.com/r/BOINC/comments/x9r5p5/20x_wcg_africa_rainfall_project_when_16gb_ram_is/ | title=20x WCG Africa Rainfall Project - when 16GB RAM is barely enough | date=9 September 2022 }}</ref>

==Completed subprojects==
===Human Proteome Folding – Phase 1===
{{Main|Human Proteome Folding Project}}

The first project launched on World Community Grid was the Human Proteome Folding Project, or HPF1, which aims to predict the structure of human [[proteins]]. The project was launched on November 16, 2004,<ref name="Completed Research" /> and completed on July 18, 2006.<ref name="Completed Research" /> This project was unique in that computation was done in tandem with the [[grid.org]] distributed computing project.<ref>{{cite web
|url=http://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=7683
|title=Launch of Human Proteome Folding Phase 2 project
|author=Viktors
|publisher=World Community Grid
|date=2006-06-26
|access-date=2007-08-04
|archive-date=2019-02-04
|archive-url=https://web.archive.org/web/20190204122437/https://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=7683
|url-status=live
}}</ref> Devised by Richard Bonneau at the [[Institute for Systems Biology]], the project used grid computing to produce the likely structures for each of the proteins using a Rosetta Score. From these predictions, researchers hope to predict the function of the myriad proteins. This increased understanding of the human proteins could prove vital in the search for cures to human [[diseases]].<ref>{{cite web
|url=http://www.worldcommunitygrid.org/projects_showcase/archives/viewHpfResearch.do
|title=Human Proteome Folding Project
|work=Research
|publisher=World Community Grid
|access-date=2007-08-04
|archive-date=2007-08-20
|archive-url=https://web.archive.org/web/20070820042136/http://www.worldcommunitygrid.org/projects_showcase/archives/viewHpfResearch.do
|url-status=live
}}</ref> Computing for this project was officially completed on July 18, 2006.<ref>{{cite web
|url=http://www.worldcommunitygrid.org/projects_showcase/archives/viewHpfOverview.do
|title=Human Proteome Folding Project Overview
|work=Research
|publisher=World Community Grid
|access-date=2007-07-28
|archive-date=2007-07-14
|archive-url=https://web.archive.org/web/20070714022845/http://www.worldcommunitygrid.org/projects_showcase/archives/viewHpfOverview.do
|url-status=live
}}</ref>  Research results for the yeast portion of HPF1 have been published.<ref>{{cite journal | vauthors = Malmström L, Riffle M, Strauss CE, Chivian D, Davis TN, Bonneau R, Baker D | title = Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology | journal = PLOS Biology | volume = 5 | issue = 4 | pages = e76 | date = April 2007 | pmid = 17373854 | pmc = 1828141 | doi = 10.1371/journal.pbio.0050076 | doi-access = free }}</ref>

===Human Proteome Folding – Phase 2===
{{Main|Human Proteome Folding Project}}

'''Human Proteome Folding - Phase 2 (HPF2)''' (launched June 23, 2006<ref name="Active Research" />) was the third project to run on World Community Grid, and completed in 2013. This project, following on from HPF1, focused on human-secreted [[proteins]], with special focus on [[Biomarker (medicine)|biomarkers]] and the proteins on the surface of cells as well as [[Plasmodium]], the organism that causes malaria. HPF2 generates higher-resolution protein models than HPF1. Though these higher-resolution models are more useful, they also require more processing power to generate.<ref>{{cite web
|url=http://www.worldcommunitygrid.org/projects_showcase/viewHpf2Research.do
|title=Human Proteome Folding - Phase 2
|publisher=World Community Grid
|access-date=2007-07-28
|archive-date=2007-08-10
|archive-url=https://web.archive.org/web/20070810070933/http://www.worldcommunitygrid.org/projects_showcase/viewHpf2Research.do
|url-status=live
}}</ref>

In a July 2012 status report, the project scientists reported that the results generated by the WCG calculations are being used by Dr. Markus Landthaler of the Max Delbruch Center for Molecular Medicine (MDC) in Berlin. The HPF2 results helped Dr. Markus Landthaler and his collaborators in writing up a new paper on "The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts"<ref>{{cite journal | vauthors = Baltz AG, Munschauer M, Schwanhäusser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M | display-authors = 6 | title = The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts | journal = Molecular Cell | volume = 46 | issue = 5 | pages = 674–90 | date = June 2012 | pmid = 22681889 | doi = 10.1016/j.molcel.2012.05.021 | doi-access = free }}</ref>

===Help Defeat Cancer===
{{Main|Help Defeat Cancer}}

The Help Defeat Cancer project seeks to improve the ability of medical professionals to determine the best treatment options for patients with breast, head, or neck cancer. The project was launched on July 20, 2006,<ref name="Completed Research" /> and completed in April 2007.<ref name="Completed Research" /> The project worked by identifying visual patterns in large numbers of [[tissue microarray]]s taken from archived tissue samples. By correlating the pattern data with information about treatment and patient outcome, the results of this project could help provide better targeted treatment options.<ref>{{cite web
|url=http://www.worldcommunitygrid.org/projects_showcase/archives/hdc/viewHdcAbout.do
|title=About the Project
|work=Research: Help Defeat Cancer
|publisher=World Community Grid
|access-date=2007-08-04
|archive-date=2007-10-05
|archive-url=https://web.archive.org/web/20071005133324/http://www.worldcommunitygrid.org/projects_showcase/archives/hdc/viewHdcAbout.do
|url-status=live
}}</ref>

===Genome Comparison===
{{Main|Fiocruz Genome Comparison Project}}

The Genome Comparison project is sponsored by the [[Brazil]]ian research institution [[Instituto Oswaldo Cruz|Fiocruz]].<ref name="Active Research" /> The project was launched on November 21, 2006,<ref name="Completed Research" /> and completed on July 21, 2007.<ref name="Completed Research" /> The project seeks to compare gene sequences of different organisms against each other in order to find similarities between them.  Scientists hope to discover what purpose a particular gene sequence serves in a particular function of one organism, via comparing it to a similar gene sequence of known function in another organism.<ref>{{cite web
|url=http://www.worldcommunitygrid.org/projects_showcase/fgc/viewFgcMain.do
|title=Genome Comparison Overview
|work=Research
|publisher=World Community Grid
|access-date=2007-07-28
|archive-date=2007-07-07
|archive-url=https://web.archive.org/web/20070707214605/http://www.worldcommunitygrid.org/projects_showcase/fgc/viewFgcMain.do
|url-status=live
}}</ref>

===Help Cure Muscular Dystrophy – Phase 1===
{{Main|Help Cure Muscular Dystrophy}}

Help Cure Muscular Dystrophy is run by [[Décrypthon]], a collaboration between French Muscular Dystrophy Association, [[CNRS|French National Center for Scientific Research]] and [[IBM]]. Phase 1 was launched on December 19, 2006,<ref name="Active Research" /> and completed on June 11, 2007.<ref name="Help Cure Muscular Dystrophy Phase 1 complete" /> The project investigated [[protein–protein interactions]] for 40,000 proteins whose structures are known, with particular focus on those proteins that play a role in [[neuromuscular diseases]]. The database of information produced will help researchers design molecules to inhibit or enhance binding of particular [[macromolecules]], hopefully leading to better treatments for [[muscular dystrophy]] and other neuromuscular diseases.<ref>{{cite web
|url=http://www.worldcommunitygrid.org/projects_showcase/hcmd/viewHcmdMain.do
|title=Help Cure Muscular Dystrophy
|work=Research
|publisher=World Community Grid
|access-date=2007-07-28
|archive-date=2007-07-01
|archive-url=https://web.archive.org/web/20070701150940/http://www.worldcommunitygrid.org/projects_showcase/hcmd/viewHcmdMain.do
|url-status=live
}}</ref> This project was available only to agents running the [[Grid MP]] client, making it unavailable to users running [[BOINC]].<ref>{{cite web
|url=http://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=10647
|title=Launch of the Help Cure Muscular Dystrophy Project
|author=Viktors
|publisher=World Community Grid
|date=2006-12-19
|access-date=2007-07-28
|archive-date=2019-01-30
|archive-url=https://web.archive.org/web/20190130094526/https://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=10647
|url-status=live
}}</ref>

===Discovering Dengue Drugs – Together===
{{Main|Discovering Dengue Drugs – Together}}

Discovering Dengue Drugs – Together was sponsored by scientists at the [[University of Texas]] and the [[University of Chicago]] and will run in two phases.<ref>{{cite web |url=http://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=14561#109721 |title=Re: Project about dengue ever |author=Didactylos |publisher=World Community Grid |date=2007-06-21 |access-date=2007-08-07 |archive-date=2022-09-05 |archive-url=https://web.archive.org/web/20220905052735/https://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=14561#109721 |url-status=live }}</ref> Phase 1, launched August 21, 2007,<ref name="Active Research" /> used AutoDock 2007 (the same software used for [[FightAIDS@Home]]) to test potential antiviral drugs (through NS3 [[protease]] inhibition) against viruses from the family [[flaviviridae]] and completed on August 11, 2009.<ref name="DDDTcomplete" /><ref>{{cite web
|url=http://www.worldcommunitygrid.org/projects_showcase/dddt/viewDddtAbout.do
|title=Discovering Dengue Drugs – Together: About the Project
|publisher=World Community Grid
|access-date=2007-08-24
|archive-date=2007-10-05
|archive-url=https://web.archive.org/web/20071005035229/http://www.worldcommunitygrid.org/projects_showcase/dddt/viewDddtAbout.do
|url-status=live
}}</ref> Phase 2 "[uses] a more computationally intensive program to screen the candidates that make it through Phase 1."<ref name="lawrencehardin">{{cite web
|url=http://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=15192#114871
|title=Re: Results...
|author=lawrencehardin
|publisher=World Community Grid
|date=2007-07-10
|access-date=2007-08-07
|archive-date=2022-09-05
|archive-url=https://web.archive.org/web/20220905052735/https://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=15192#114871
|url-status=live
}}</ref> The drug candidates that make it through Phase 2 will then be lab-tested.<ref name="lawrencehardin" />

===AfricanClimate@Home===
The mission of AfricanClimate@Home was to develop more accurate climate models of specific regions in Africa. It was intended to serve as a basis for understanding how the climate will change in the future so that measures designed to alleviate the adverse effects of climate change could be implemented. World Community Grid's tremendous computing power was used to understand and reduce the uncertainty with which climate processes were simulated over Africa. Phase 1 of African Climate@Home launched on September 3, 2007,<ref name="AfricanClimate launch">{{cite web|url=http://www.csag.uct.ac.za/worldcommunitygrid|title=AfricanClimate@Home (IBM World Community Grid) Status Page|publisher=[[University of Cape Town]]|access-date=2009-05-08|archive-date=2009-11-06|archive-url=https://web.archive.org/web/20091106150030/http://www.csag.uct.ac.za/worldcommunitygrid|url-status=live}}</ref> and ended in July 2008.<ref name="AfricanClimate SC">{{cite web|url=http://www.worldcommunitygrid.org/projects_showcase/ach/viewAchMain.do|title=AfricanClimate@Home|publisher=World Community Grid|access-date=2009-05-08|archive-date=2009-05-03|archive-url=https://web.archive.org/web/20090503094244/http://www.worldcommunitygrid.org/projects_showcase/ach/viewAchMain.do|url-status=live}}</ref>

===Help Conquer Cancer===
{{Main|Help Conquer Cancer}}

'''Help Conquer Cancer''' project (launched November 1, 2007<ref name="Help Conquer Cancer-WGR" />) is sponsored by the [[Ontario Cancer Institute]] (OCI), Princess Margaret Hospital and University Health Network of Toronto, Canada. The project involves [[X-ray crystallography]]. The mission of Help Conquer Cancer is to improve the results of protein X-ray crystallography, which helps researchers not only annotate unknown parts of the human proteome, but importantly improves their understanding of cancer initiation, progression and treatment.<ref>{{cite web
|url=http://www.worldcommunitygrid.org/projects_showcase/hcc1/viewHcc1Main.do
|title=Help Conquer Cancer research page on WCG
|publisher=Worldcommunitygrid.org
|access-date=2013-05-21
|archive-date=2007-11-16
|archive-url=https://web.archive.org/web/20071116095744/http://www.worldcommunitygrid.org/projects_showcase/hcc1/viewHcc1Main.do
|url-status=live
}}</ref>

The HCC project was the first WCG project benefiting from [[graphics processing unit]]s (GPU)s which helped finish it a lot earlier than initially projected due to the massive power of GPUs. In the April 2013 status report<ref>{{Cite web |url=http://www.cs.utoronto.ca/~juris/WCG/UPDATE-APR2013.pdf |title=Help Conquer Cancer April 2013 Update |access-date=2013-04-11 |archive-date=2013-04-17 |archive-url=https://web.archive.org/web/20130417185421/http://www.cs.utoronto.ca/~juris/WCG/UPDATE-APR2013.pdf |url-status=live }}</ref> the scientists report there is still a lot of data to analyze but that they are preparing a new project that will search for prognostic and predictive signatures (sets of genes, proteins, microRNAs, etc.) that help predict patient survival and response to treatment.
The project finished in May 2013.{{citation needed|date=May 2017}}

===Nutritious Rice for the World===
{{Main|Nutritious Rice for the World}}

The [http://protinfo.compbio.washington.edu/rice Nutritious Rice for the World] project is carried out by [[Ram Samudrala]]'s [http://compbio.washington.edu Computational Biology Research Group] at the [[University of Washington]]. The project was launched on May 12, 2008, and completed on April 6, 2010.<ref name="Nutritious Rice for the World" /> The purpose of this project is to predict the structure of [[protein]]s of major [[strain (biology)|strain]]s of [[rice]], in order to help [[farmer]]s [[plant breeding|breed]] better rice strains with higher [[crop yield]]s, promote greater [[plant disease|disease]] and [[pest (organism)|pest]] resistance, and utilize a full range of [[bioavailability|bioavailable]] [[nutrient]]s that can benefit people around the world, especially in regions where [[malnutrition]] is a critical concern. The project has been covered by more than 200 media outlets since its inception.<ref>{{cite web |url=http://protinfo.compbio.washington.edu/rice/press.html |title=Nutritious Rice for the World |publisher=Protinfo.compbio.washington.edu |access-date=2010-06-07 |archive-date=2010-08-13 |archive-url=https://web.archive.org/web/20100813175034/http://protinfo.compbio.washington.edu/rice/press.html |url-status=live }}</ref>  On April 13, 2010, World Community Grid officially announced that the Nutritious Rice for the World project finished on April 6, 2010.<ref name="Nutritious Rice for the World" />

In April 2014, an update was posted stating that the research team was able to publish structural information about thousands of proteins, and advance the field of computational protein modeling. These results – which were only possible because of the massive amount of donated computing power they had available – are expected to guide future research and plant science efforts.<ref>{{cite web|url=http://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=353|title=Live webcast for Nutritious Rice for the World: April 17th, 7:00pm UTC|date=15 April 2014|work=worldcommunitygrid.org|access-date=15 April 2014|archive-date=16 April 2014|archive-url=https://web.archive.org/web/20140416192231/http://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=353|url-status=live}}</ref>

===The Clean Energy Project===
{{Main|Clean Energy Project}}

The Clean Energy project is sponsored by the scientists of [[Harvard University]]'s Department of Chemistry and Chemical Biology.<ref name="Worldcommunitygrid.org">{{cite web |url=http://www.worldcommunitygrid.org/projects_showcase/cep1/viewCep1About.do |title=The Clean Energy Project research page on WCG |publisher=Worldcommunitygrid.org |access-date=2010-06-07 |archive-date=2009-04-22 |archive-url=https://web.archive.org/web/20090422051959/http://www.worldcommunitygrid.org/projects_showcase/cep1/viewCep1About.do |url-status=live }}</ref> The mission of the Clean Energy Project is to find new materials for the next generation of [[solar cell]]s and later, [[energy storage]] devices. Researchers are employing [[molecular mechanics]] and [[electronic structure]] calculations to predict the optical and transport properties of molecules that could become the next generation of solar cell materials.{{citation needed|date=May 2017}}

Phase 1 was launched on December 5, 2008, and completed on October 13, 2009.<ref name="CEP Phase 1 complete" />  By harnessing the computing power of the World Community Grid, researchers were able to calculate the electronic properties of tens of thousands of organic materials – many more than could ever be tested in a lab – and determine which candidates are most promising for developing affordable [[solar energy]] technology.<ref>{{cite web |url=http://www.worldcommunitygrid.org/projects_showcase/cep1/viewCep1Main.do |title=The Clean Energy Project research page on WCG |publisher=Worldcommunitygrid.org |access-date=2015-07-15 |archive-date=2009-04-14 |archive-url=https://web.archive.org/web/20090414165742/http://www.worldcommunitygrid.org/projects_showcase/cep1/viewCep1Main.do |url-status=live }}</ref>

Phase 2 was launched June 28, 2010,<ref name="Clean Energy Project-WCG" /> sponsored by the scientists of [[Harvard University]]'s Department of Chemistry and Chemical Biology.<ref name="Worldcommunitygrid.org" /> Further calculations about optical, electronic and other physical properties of the candidate materials are being conducted with the [[Q-Chem]] quantum chemistry software.<ref>[http://www.worldcommunitygrid.org/research/cep2/overview.do The Clean Energy Project - Phase 2] {{Webarchive|url=https://web.archive.org/web/20110717130155/http://www.worldcommunitygrid.org/research/cep2/overview.do |date=2011-07-17 }} "World Community Grid", access-date=2015/7/15</ref> Their findings have been submitted to the [[Energy & Environmental Science]] journal.<ref>{{Cite web|url=https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=519|title=Clean Energy Project Researchers Sharing Results and Planning for the Future|website=www.worldcommunitygrid.org|language=en-US|access-date=2018-03-04|archive-date=2017-07-24|archive-url=https://web.archive.org/web/20170724103810/https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=519|url-status=live}}</ref>

===Help Fight Childhood Cancer===

'''Help Fight Childhood Cancer''' project (launched March 13, 2009<ref name="Help Fight Childhood Cancer-WCG" />) is sponsored by the scientists at [[Chiba Cancer Center Research Institute]] and [[Chiba University]].<ref>{{cite web
|url=http://www.worldcommunitygrid.org/projects_showcase/hfcc/viewHfccAbout.do
|title=Help Fight Childhood Cancer research page on WCG
|publisher=Worldcommunitygrid.org
|date=2009-03-13
|access-date=2010-06-07
|archive-date=2009-04-21
|archive-url=https://web.archive.org/web/20090421073426/http://www.worldcommunitygrid.org/projects_showcase/hfcc/viewHfccAbout.do
|url-status=live
}}</ref> The mission of the Help Fight Childhood Cancer project is to find drugs that can disable three particular proteins associated with [[neuroblastoma]], one of the most frequently occurring [[solid tumors]] in children. Identifying these drugs could potentially make the disease much more curable when combined with [[chemotherapy treatment]].<ref>{{cite web
|url=http://www.worldcommunitygrid.org/projects_showcase/hfcc/viewHfccMain.do
|title=Help Fight Childhood Cancer research page on WCG
|publisher=Worldcommunitygrid.org
|date=2009-03-13
|access-date=2010-06-07
|archive-date=2009-05-03
|archive-url=https://web.archive.org/web/20090503115920/http://www.worldcommunitygrid.org/projects_showcase/hfcc/viewHfccMain.do
|url-status=live
}}</ref>

===Influenza Antiviral Drug Search===
{{Main|Influenza Antiviral Drug Search}}

Influenza Antiviral Drug Search project is sponsored by Dr. Stan Watowich and his research team at [[The University of Texas]] Medical Branch ([[Galveston]], [[Texas]], USA).<ref>{{cite web |url=http://www.worldcommunitygrid.org/projects_showcase/flu1/viewFlu1Part.do |title=Influenza Antiviral Drug Search research page on WCG |publisher=Worldcommunitygrid.org |access-date=2010-06-07 |archive-date=2009-05-30 |archive-url=https://web.archive.org/web/20090530141929/http://www.worldcommunitygrid.org/projects_showcase/flu1/viewFlu1Part.do |url-status=live }}</ref> The project was launched on May 5, 2009, and completed on October 22, 2009.<ref name="flu1complete" /> The mission of the Influenza [[Antiviral drug|Antiviral Drug]] Search project is to find new drugs that can stop the spread of an [[influenza]] infection in the body. The research will specifically address the influenza strains that have become drug resistant as well as new strains that are appearing. Identifying the chemical compounds that are the best candidates will accelerate the efforts to develop treatments that would be useful in managing seasonal influenza outbreaks, and future influenza epidemics and even pandemics.<ref>{{cite web |url=http://www.worldcommunitygrid.org/projects_showcase/flu1/viewFlu1Main.do |title=Influenza Antiviral Drug Search research page on WCG |publisher=Worldcommunitygrid.org |access-date=2010-06-07 |archive-date=2009-05-09 |archive-url=https://web.archive.org/web/20090509074644/http://www.worldcommunitygrid.org/projects_showcase/flu1/viewFlu1Main.do |url-status=live }}</ref> Phase 1 of The Influenza Antiviral Drug Search project has already finished on October 22, 2009. Now the researchers are performing post-processing on the results from Phase 1 and are preparing for Phase 2.<ref name="flu1complete" />

In November 2012, the project's scientists stated that, given the fact that there is no immediate danger of an influenza outbreak, all of the project's results would be posted online and their resources would be refocused on the Dengue Project.<ref>{{cite web|url=http://www.worldcommunitygrid.org/forums/wcg/viewthread_thread,34244|title=Discovering Dengue Drugs – Together project update|publisher=World Community Grid forums|date=2012-11-14|access-date=2014-04-28|archive-date=2015-01-19|archive-url=https://web.archive.org/web/20150119154556/http://www.worldcommunitygrid.org/forums/wcg/viewthread_thread,34244|url-status=live}}</ref>

===Help Cure Muscular Dystrophy – Phase 2===
{{Main|Help Cure Muscular Dystrophy}}

World Community Grid and researchers supported by Decrypthon, a partnership between AFM (French Muscular Dystrophy Association), [[CNRS]] (French National Center for Scientific Research), Universite Pierre et Marie Curie, and IBM were investigating protein–protein interactions for more than 2,200 proteins whose structures are known, with particular focus on those proteins that play a role in [[neuromuscular diseases]]. Phase 2 was launched on May 12, 2009,<ref name="HCMD Phase 2 launch" /> and completed on September 26, 2012. The database of information produced will help researchers design molecules to inhibit or enhance binding of particular [[macromolecules]], hopefully leading to better treatments for [[muscular dystrophy]] and other neuromuscular diseases.<ref>{{cite web
|url=http://www.worldcommunitygrid.org/projects_showcase/hcmd2/viewHcmd2Main.do
|title=Help Cure Muscular Dystrophy Phase 2 research page on WCG
|publisher=Worldcommunitygrid.org
|access-date=2013-05-21
|archive-date=2009-06-02
|archive-url=https://web.archive.org/web/20090602131147/http://www.worldcommunitygrid.org/projects_showcase/hcmd2/viewHcmd2Main.do
|url-status=live
}}</ref>

Phase 2 of the Help Cure Muscular Dystrophy project began once the results from the first phase had been analyzed. Phase 2 ran on the [[BOINC]] platform.<ref name="bbover3" /><ref>{{cite web
|url=http://www.worldcommunitygrid.org/projects_showcase/hcmd/viewHcmdFaq.do
|title=Help Cure Muscular Dystrophy
|work=Research - Project FAQs
|publisher=World Community Grid
|access-date=2013-05-21
|archive-date=2009-07-06
|archive-url=https://web.archive.org/web/20090706212557/http://www.worldcommunitygrid.org/projects_showcase/hcmd/viewHcmdFaq.do
|url-status=live
}}</ref>

===Discovering Dengue Drugs – Together – Phase 2===
{{Main|Discovering Dengue Drugs - Together}}

'''Discovering Dengue Drugs – Together – Phase 2''' (launched February 17, 2010<ref name="Discovering Dengue Drugs - Together-WCG" />) is sponsored by [[The University of Texas Medical Branch]] (UTMB) in [[Galveston]], [[Texas]], United States and the [[University of Chicago]] in [[Illinois]], USA. The mission is to identify promising drug candidates to combat the [[Dengue fever|Dengue]], [[Hepatitis C]], [[West Nile virus|West Nile]], [[Yellow Fever]], and other related viruses. The extensive computing power of World Community Grid will be used to complete the structure-based drug discovery calculations required to identify these drug candidates.<ref>{{cite web
|url=http://www.worldcommunitygrid.org/research/dddt2/overview.do
|title=Discovering Dengue Drugs - Together - Phase 2
|work=Research - Project Overview
|publisher=World Community Grid
|access-date=2013-05-21
|archive-date=2013-04-20
|archive-url=https://web.archive.org/web/20130420064341/http://www.worldcommunitygrid.org/research/dddt2/overview.do
|url-status=live
}}</ref>

===Computing for Clean Water===
'''Computing for Clean Water''' (launched September 20, 2010<ref name="Computing for Clean Water-WCG" /><ref name="Computing for Clean Water-Tsinghua" />) is sponsored by the Center for Nano and Micro Mechanics of [[Tsinghua University]] in [[Beijing]]. The project's mission is to provide deeper insight on the molecular scale into the origins of the efficient flow of water through a novel class of filter materials. This insight will in turn guide future development of low-cost and more efficient water filters. It is estimated that 1.2 billion people lack access to safe drinking water, and 2.6 billion have little or no sanitation. As a result, millions of people die annually – an estimated 3,900 children a day due to a lack of clean water.<ref>{{cite web|url=http://www.worldcommunitygrid.org/research/c4cw/overview.do|title=World Community Grid - Research - Computing for Clean Water|work=worldcommunitygrid.org|access-date=2011-10-27|archive-date=2011-10-30|archive-url=https://web.archive.org/web/20111030022726/http://www.worldcommunitygrid.org/research/c4cw/overview.do|url-status=live}}</ref> On April 25, 2014, the project scientists released an update stating that they had exciting results to report when the paper is submitted and that the project on WCG was finished.<ref>{{cite web|url=http://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=355|title=Computing for Clean Water project update|date=25 April 2014|vauthors=Grey F|work=worldcommunitygrid.org|access-date=25 April 2014|archive-date=26 April 2014|archive-url=https://web.archive.org/web/20140426214758/http://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=355|url-status=live}}</ref>

===Drug Search for Leishmaniasis===
'''Drug Search for Leishmaniasis''' (launched September 7, 2011<ref name="Drug Search for Leishmaniasis-WCG" />) is spearheaded by the [[University of Antioquia]] in [[Medellín]], [[Colombia]], with assistance from researchers at the University of Texas Medical Branch in Galveston, Texas. The mission is to identify potential molecule candidates that could possibly be developed into treatments for [[Leishmaniasis]]. The extensive computing power of World Community Grid will be used to perform computer simulations of the interactions between millions of chemical compounds and certain target proteins. This will help find the most promising compounds that may lead to effective treatments for the disease.<ref>{{cite web
|url=http://www.worldcommunitygrid.org/research/dsfl/overview.do
|title=Drug Search for Leishmaniasis
|work=Research
|publisher=World Community Grid
|access-date=2011-10-28
|archive-date=2021-07-16
|archive-url=https://web.archive.org/web/20210716010153/https://www.worldcommunitygrid.org/research/dsfl/overview.do
|url-status=live
}}</ref>

===GO Fight Against Malaria Project===
The mission of the '''GO Fight Against Malaria''' project (launched November 16, 2011<ref name="GO Fight Against Malaria Project-WCG" />) is to discover promising drug candidates that could be developed into new drugs that cure drug resistant forms of [[malaria]]. The computing power of World Community Grid will be used to perform computer simulations of the interactions between millions of chemical compounds and certain target proteins, to predict their ability to eliminate malaria. The best compounds will be tested by scientists at [[The Scripps Research Institute]] in La Jolla, California, U.S.A. and further developed into possible treatments for the disease.<ref>{{cite web |url=http://www.worldcommunitygrid.org/research/gfam/overview.do |title=GO Fight Against Malaria Project |work=Research |publisher=World Community Grid |access-date=2013-04-11 |archive-date=2013-04-05 |archive-url=https://web.archive.org/web/20130405033145/http://www.worldcommunitygrid.org/research/gfam/overview.do |url-status=live }}</ref>

===Say No to Schistosoma===
'''Say No to Schistosoma''' (launched February 22, 2012<ref name="Say No to Schistosoma Project-WCG" />) was the 20th research project to be launched on World Community Grid. The researchers at [[Infórium University]] in [[Belo Horizonte]] and [[FIOCRUZ-Minas]], [[Brazil]], ran this project on World Community Grid to perform computer simulations of the interactions between millions of chemical compounds and certain target proteins in the hope of finding effective treatments for [[schistosomiasis]].<ref>{{cite web |url=http://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=194 |title=Say No to Schistosoma |work=Research |publisher=World Community Grid |access-date=2012-05-24 |archive-date=2012-04-06 |archive-url=https://web.archive.org/web/20120406110301/http://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=194 |url-status=live }}</ref> As of April 2015, subsequent analysis had been performed, and three of the most promising candidate substances had been identified for in-vitro testing.<ref name="secure.worldcommunitygrid.org" />

===Computing for Sustainable Water===
'''Computing for Sustainable Water''' was the 21st research project to be launched on World Community Grid. The researchers at the [[University of Virginia]] were running this project on World Community Grid to study the effects of human activity on a large watershed and gain deeper insights into what actions can support the restoration, health and sustainability of this important water resource.<ref>{{cite web |url=http://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=198 |title=Computing for Sustainable Water |work=Research |publisher=World Community Grid |access-date=2013-05-21 |archive-date=2013-04-20 |archive-url=https://web.archive.org/web/20130420093138/http://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=198 |url-status=live }}</ref> The project was launched on April 17, 2012,<ref name="CSW Launch" /> and completed on October 17, 2012.

===Uncovering Genome Mysteries===
'''The Uncovering Genome Mysteries''' project launched on October 16, 2014, and is a joint collaboration between Australian and Brazilian scientists. The project aims to examine close to 200 million genes from many life forms and compare them with known genes in order to find out what their function is. The results could have an effect in fields such as medicine and environmental research.<ref>{{cite web|url=https://secure.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=385|title=Project Launch: Uncovering Genome Mysteries|work=worldcommunitygrid.org|access-date=2014-10-24|archive-date=2014-10-24|archive-url=https://web.archive.org/web/20141024225650/https://secure.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=385|url-status=live}}</ref>

===Outsmart Ebola Together===
'''Outsmart Ebola Together''' was a collaboration with the [[Scripps Research Institute]] to help find chemical compounds to fight [[Ebola virus disease]].<ref>{{cite news|url=https://time.com/3634732/ibm-ebola-cure/|title=How Your Tablet Can Help Find an Ebola Cure|date=19 December 2014|access-date=19 December 2014|vauthors=Park A|archive-date=8 October 2016|archive-url=https://web.archive.org/web/20161008213119/http://time.com/3634732/ibm-ebola-cure/|url-status=live}}</ref> It was launched on 3 December 2014.<ref>{{cite web|url=http://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=401|title=Help researchers find an Ebola cure|vauthors=Saphire EO|date=3 December 2014|access-date=20 December 2014|archive-date=20 December 2014|archive-url=https://web.archive.org/web/20141220220349/http://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=401|url-status=live}}</ref> The aim is to block crucial steps in the life cycle of the virus, by finding drugs with high [[binding affinity]] with certain of its proteins. There are two targets: a surface protein used by the virus to infect human cells, and "transformer" proteins which change shape to carry out different functions.<ref>{{cite web|url=http://www.worldcommunitygrid.org/research/oet1/details.do|title=Let's outsmart Ebola together:About the Project|date=December 2014|access-date=20 December 2014|archive-date=20 December 2014|archive-url=https://web.archive.org/web/20141220211614/http://www.worldcommunitygrid.org/research/oet1/details.do|url-status=live}}</ref> The project officially completed December 6, 2018.<ref>{{cite web |url= https://www.worldcommunitygrid.org/forums/wcg/viewthread_thread,41288 |title= Project Completed |author= <!--Not stated--> |date= 6 December 2018 |website= World Community Grid |publisher= [[IBM]] |access-date= 6 December 2018 |quote= We have completed OET. Thank you for your help and contribution towards this project. |archive-date= 30 January 2019 |archive-url= https://web.archive.org/web/20190130042554/https://www.worldcommunitygrid.org/forums/wcg/viewthread_thread,41288 |url-status= live }}</ref>

===OpenZika===
'''OpenZika''' was launched on May 18, 2016, to help combat the [[Zika virus]]. The project targets proteins that are believed to be used by the Zika virus to survive and spread in the body, based on known results from similar diseases like [[dengue fever]] and [[yellow fever]]. These results will help researchers develop an anti-Zika drug.<ref>{{citation|url=http://www.worldcommunitygrid.org/research/zika/overview.do|title=Research: OpenZika: Project Overview|access-date=19 May 2016|archive-date=22 May 2016|archive-url=https://web.archive.org/web/20160522185942/http://www.worldcommunitygrid.org/research/zika/overview.do|url-status=live}}</ref> The project officially completed December 13, 2019.<ref>{{citation|url=https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=614|title=OpenZika's Work on World Community Grid is Complete.|access-date=2020-03-05|archive-date=2020-03-05|archive-url=https://web.archive.org/web/20200305162802/https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=614|url-status=live}}</ref>

===FightAIDS@Home===
{{Main|FightAIDS@Home}}

'''FightAIDS@Home''' (launched November 19, 2005<ref name="FightAIDSatHome-PR" />) was World Community Grid's second project and its first to target a single disease.  Each individual computer processes one potential drug molecule and tests how well it would [[docking (molecular)|dock]] with [[HIV]] [[protease]], acting as a [[Protease inhibitor (pharmacology)|protease inhibitor]].<ref name="FightAIDSatHome-WCG" /> Scripps Research Institute published its first peer-reviewed scientific paper about the results of FightAIDS@Home on April 21, 2007.<ref>{{cite journal | vauthors = Chang MW, Lindstrom W, Olson AJ, Belew RK | title = Analysis of HIV wild-type and mutant structures via in silico docking against diverse ligand libraries | journal = Journal of Chemical Information and Modeling | volume = 47 | issue = 3 | pages = 1258–62 | date = 2007-04-21 | pmid = 17447753 | doi = 10.1021/ci700044s | publisher = [[American Chemical Society]] | doi-access =free  }}</ref> This paper explains that the results up to that point will primarily be used to improve the efficiency of future FightAIDS@Home calculations.<ref>{{cite web
|url=http://fightaidsathome.scripps.edu/news/vol3.pdf
|title=FightAIDS@Home News Volume 3
|publisher=[[The Scripps Research Institute]]
|date=2007-05-10
|access-date=2007-07-30
|archive-date=2007-08-08
|archive-url=https://web.archive.org/web/20070808120748/http://fightaidsathome.scripps.edu/news/vol3.pdf
|url-status=live
}}</ref>

===FightAIDS@Home Phase 2===
'''FightAIDS@Home Phase 2''' (launched September 30, 2015<ref>{{cite web |url= https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=447 |title= Pioneering new techniques in the fight against HIV |vauthors= Olson A |date= 30 September 2015 |website= World Community Grid |publisher= IBM |access-date= 21 June 2018 |archive-date= 30 January 2019 |archive-url= https://web.archive.org/web/20190130035252/https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=447 |url-status= live }}</ref>) is looking more closely at the results of Phase 1. The project has two goals in the early experiments; the simulation architecture is functioning correctly and giving reliable results, and using BEDAM and [[AutoDock]] together provides better results than using just BEDAM or AutoDock.<ref>{{cite web |url= https://fightaidsathome2.cst.temple.edu/ |title= FightAIDS@Home - Phase II: Introduction |author= <!--Not stated--> |website= FightAIDS@Home - Phase II |publisher= College of Science and Technology Temply University |access-date= 2 July 2018 |quote= The first experiments of FightAIDS@Home Phase 2 seek to achieve two goals: first, to confirm that the new simulation schema is working as intended and gives sufficiently reliable results compared to traditionally run simulations; second, to demonstrate that using BEDAM in conjunction with AutoDock results in better predictions than using AutoDock or BEDAM alone. |archive-date= 12 April 2018 |archive-url= https://web.archive.org/web/20180412145421/https://fightaidsathome2.cst.temple.edu/ |url-status= live }}</ref>

===Microbiome Immunity Project===
'''Microbiome Immunity Project''' (launched August 2017) is a study of proteins in bacteria located in and on the human body; the [[human microbiota|human microbiome]], which comprises around 3 million separate bacterial genes. By studying bacterial genes, researchers can determine their individual shapes, which in turn dictate the function of the bacteria.<ref>{{cite web|author=<!--Not stated-->|title=Microbiome Immunity Project|url=https://www.worldcommunitygrid.org/research/mip1/overview.do|access-date=2 July 2018|website=World Community Grid|archive-date=14 August 2018|archive-url=https://web.archive.org/web/20180814221521/https://www.worldcommunitygrid.org/research/mip1/overview.do|url-status=live}}</ref> Collaborative institutions includes the [[University of California San Diego]], [[Broad Institute]] of MIT and Harvard, and the [[Simons Foundation|Simons Foundation's]] Flatiron Institute.<ref>{{cite web|date=19 June 2018|title=Microbiome Immunity Project Researchers Create Ambitious Plans for Data|url=https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=565|access-date=2 July 2018|website=World Community Grid|vauthors=Kościółek T, Taylor B|archive-date=14 August 2018|archive-url=https://web.archive.org/web/20180814223743/https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=565|url-status=live}}</ref>

===Help Stop TB===
'''Help Stop TB''' was launched in March 2016 to help combat [[tuberculosis]], a disease caused by a [[bacterium]] that is evolving resistance to currently available treatments. The computations of this project target [[mycolic acid]]s in the bacterium's protective coat, simulating the behaviour of these molecules to better understand how they offer protection to the bacteria.<ref>{{Cite web|url=https://www.worldcommunitygrid.org/research/hst1/overview.do|title=Help Stop TB|website=World Community Grid|archive-url=https://web.archive.org/web/20190619091547/https://www.worldcommunitygrid.org/research/hst1/overview.do|archive-date=June 19, 2019|url-status=live|access-date=June 19, 2019}}</ref>

===Smash Childhood Cancer===
{{Main|Smash Childhood Cancer}}

Launched in January 2017, the '''Smash Childhood Cancer''' project builds on the work from the Help Fight Childhood Cancer project by looking for drug candidates targeting additional childhood cancers.<ref>{{Cite web|url=https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=537|title=The Road Ahead for Help Fight Childhood Cancer|website=www.worldcommunitygrid.org|language=en-US|access-date=2018-03-04|archive-date=2019-01-30|archive-url=https://web.archive.org/web/20190130043514/https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=537|url-status=live}}</ref><ref>{{Cite web|url=https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=512|title=Researchers Reunite with World Community Grid to Smash Childhood Cancer|website=www.worldcommunitygrid.org|language=en-US|access-date=2018-03-04|archive-date=2019-01-30|archive-url=https://web.archive.org/web/20190130154450/https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=512|url-status=live}}</ref> Upon Dr. Akira Nakagawara's retirement in March 2020, the principal investigator changed to Dr. Godfrey Chan, who was one of the original members of the Smash Childhood Cancer team. Additionally, PRDM14 and Fox01 have been added as new targets for investigation.<ref>{{cite web |url= https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=620 |title= Smash Childhood Cancer Team Announces New Principal Investigator and New Project Targets |author= The Smash Childhood Cancer research team |date= 9 March 2020 |website= World Community Grid |publisher= [[IBM]] |access-date= 10 March 2020 |archive-date= 19 July 2020 |archive-url= https://web.archive.org/web/20200719015440/https://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=620 |url-status= live }}</ref> An inhibitor of the [[Osteopontin#Cancer|osteopontin]] protein was modeled.<ref>{{Cite web |title=Research update from the SCC team (October 2022) |url=https://www.worldcommunitygrid.org/about_us/article.s?articleId=777 |access-date=2022-11-01 |website=www.worldcommunitygrid.org}}</ref>

== See also ==
* [[BOINC]]
* [[Folding@home]]
* [[List of volunteer computing projects]]
* [[World community]]

== References ==
{{Reflist|refs=
<ref name="FightAIDSatHome-PR">{{cite press release |url=http://www.scripps.edu/news/press/112105.html |title=World Community Grid Targets AIDS in Giant Research Effort |date=2005-11-21 |access-date=2007-07-28 |archive-date=2007-09-29 |archive-url=https://web.archive.org/web/20070929104851/http://www.scripps.edu/news/press/112105.html |url-status=live }}</ref><ref name="FightAIDSatHome-WCG">{{cite web |url=http://www.worldcommunitygrid.org/projects_showcase/viewFaahResearch.do |title=FightAIDS@Home |work=Research |publisher=World Community Grid |access-date=2007-07-28 |archive-date=2007-08-10 |archive-url=https://web.archive.org/web/20070810071008/http://www.worldcommunitygrid.org/projects_showcase/viewFaahResearch.do |url-status=live }}</ref><ref name="Active Research">{{cite web |url=http://www.worldcommunitygrid.org/projects_showcase/viewResearch.do |title=Active Research |work=Research |publisher=World Community Grid |access-date=2007-07-28 |archive-date=2007-08-10 |archive-url=https://web.archive.org/web/20070810071202/http://www.worldcommunitygrid.org/projects_showcase/viewResearch.do |url-status=live }}</ref><ref name="Help Conquer Cancer-WGR">{{cite web |url=http://www.worldcommunitygrid.org/forums/wcg/viewthread_thread,16924_offset,0#135271 |title=Launch of the Help Conquer Cancer Project |date=2007-11-01 |publisher=World Community Grid |access-date=2011-10-28 |archive-date=2019-01-31 |archive-url=https://web.archive.org/web/20190131121318/https://www.worldcommunitygrid.org/forums/wcg/viewthread_thread,16924_offset,0#135271 |url-status=live }}</ref><ref name="Help Fight Childhood Cancer-WCG">{{cite web |url=http://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=24765&offset=0 |title=Launch of the Help Fight Childhood Cancer Project |date=2009-03-13 |publisher=World Community Grid |access-date=2011-10-28 |archive-date=2022-02-26 |archive-url=https://web.archive.org/web/20220226152404/https://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=24765&offset=0 |url-status=live }}</ref><ref name="Discovering Dengue Drugs - Together-WCG">{{cite web |url=http://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=121 |title=Launch of Discovering Dengue Drugs - Together - Phase 2 Project |date=17 February 2010 |publisher=World Community Grid |access-date=2011-10-28 |archive-date=2011-08-08 |archive-url=https://web.archive.org/web/20110808214458/http://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=121 |url-status=live }}</ref>
<ref name="Clean Energy Project-WCG">{{cite web |url=http://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=134 |title=Launch of The Clean Energy Project - Phase 2 |date=2010-06-28 |publisher=World Community Grid |access-date=2011-10-28 |archive-date=2011-08-08 |archive-url=https://web.archive.org/web/20110808214128/http://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=134 |url-status=live }}</ref>
<ref name="Computing for Clean Water-WCG">{{cite web |url=http://www.worldcommunitygrid.org/forums/wcg/viewthread_thread,29672 |title=Computing for Clean Water Announcements |date=2010-08-23 |publisher=World Community Grid |access-date=2010-10-25 |archive-date=2019-01-31 |archive-url=https://web.archive.org/web/20190131041544/https://www.worldcommunitygrid.org/forums/wcg/viewthread_thread,29672 |url-status=live }}</ref>
<ref name="Computing for Clean Water-Tsinghua">{{cite web |url=http://cnmm.tsinghua.edu.cn/contents/1/89.html |title=Computing for Clean Water |date=2010-09-20 |publisher=Center for Nano and Micro Mechanics, [[Tsinghua University]] |location=[[Beijing]] |access-date=2010-10-25 |archive-date=2016-03-03 |archive-url=https://web.archive.org/web/20160303203439/http://cnmm.tsinghua.edu.cn/contents/1/89.html |url-status=live }}</ref>
<ref name="Drug Search for Leishmaniasis-WCG">{{cite web |url=http://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=170 |title=Launch of the Drug Search for Leishmaniasis Project |date=2011-09-07 |publisher=World Community Grid |access-date=2011-10-28 |archive-date=2011-11-04 |archive-url=https://web.archive.org/web/20111104125828/http://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=170 |url-status=live }}</ref>
<ref name="GO Fight Against Malaria Project-WCG">{{cite web |url=http://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=188 |title=Launch of the GO Fight Against Malaria Project |date=2011-11-16 |publisher=World Community Grid |access-date=2012-01-11 |archive-date=2012-01-25 |archive-url=https://web.archive.org/web/20120125054534/http://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=188 |url-status=live }}</ref>
<ref name="Say No to Schistosoma Project-WCG">{{cite web |url=http://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=194 |title=Launch of the Say No to Schistosoma Project |date=2012-02-22 |publisher=World Community Grid |access-date=2012-05-24 |archive-date=2012-04-06 |archive-url=https://web.archive.org/web/20120406110301/http://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=194 |url-status=live }}</ref>
<ref name="Completed Research">{{cite web |url=http://www.worldcommunitygrid.org/projects_showcase/archives/hdc/viewHdcOverview.do |title=Help Defeat Cancer Project Overview |work=Research |publisher=World Community Grid |access-date=2007-08-04 |archive-date=2007-08-22 |archive-url=https://web.archive.org/web/20070822232648/http://www.worldcommunitygrid.org/projects_showcase/archives/hdc/viewHdcOverview.do |url-status=live }}</ref>
<ref name="Help Cure Muscular Dystrophy Phase 1 complete">{{cite web |url=http://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=14142 |title=Help Cure Muscular Dystrophy Phase 1 has completed |author=uplinger |publisher=World Community Grid |date=2007-06-11 |access-date=2007-07-28 |archive-date=2019-01-31 |archive-url=https://web.archive.org/web/20190131071350/https://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=14142 |url-status=live }}</ref>
<ref name="DDDTcomplete">{{cite web
|url=http://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=26618
|title=Discovering Dengue Drugs&nbsp;– Together (Phase 1) Completion
|publisher=World Community Grid
|date=2009-08-26
|access-date=2009-08-27
|archive-date=2013-07-04
|archive-url=https://web.archive.org/web/20130704071103/http://www.worldcommunitygrid.org/forums/wcg/viewthread?thread=26618
|url-status=live
}}</ref>
<ref name="CEP Phase 1 complete">{{cite web
|url=http://www.worldcommunitygrid.org/forums/wcg/viewthread_thread,27723
|title=The Clean Energy Project (Phase 1) Completion
|publisher=World Community Grid
|date=2009-10-15
|access-date=2009-11-25
|archive-date=2019-01-30
|archive-url=https://web.archive.org/web/20190130112547/https://www.worldcommunitygrid.org/forums/wcg/viewthread_thread,27723
|url-status=live
}}</ref>
<ref name=flu1complete >{{cite web
|url=https://secure.worldcommunitygrid.org/forums/wcg/viewthread_thread,27884
|title=Influenza Antiviral Drug Search (Phase 1) Completion
|publisher=World Community Grid
|date=2009-11-09
|access-date=2009-11-25
|archive-date=2022-09-05
|archive-url=https://web.archive.org/web/20220905052733/https://www.worldcommunitygrid.org/forums/wcg/viewthread_thread,27884
|url-status=live
}}</ref>
<ref name="Nutritious Rice for the World">{{cite web
|url=http://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=126
|title=End of Nutritious Rice for the World project
|publisher=World Community Grid
|date=2010-04-13
|access-date=2010-04-16
|archive-date=2010-04-17
|archive-url=https://web.archive.org/web/20100417111843/http://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=126
|url-status=live
}}</ref>
<ref name="HCMD Phase 2 launch">{{cite web
|url=http://www.worldcommunitygrid.org/forums/wcg/viewthread_thread,25571
|title=Launch of the Help Cure Muscular Dystrophy – Phase 2 Project
|date=2009-05-12
|publisher=World Community Grid
|access-date=2011-10-28
|archive-date=2019-01-30
|archive-url=https://web.archive.org/web/20190130112118/https://www.worldcommunitygrid.org/forums/wcg/viewthread_thread,25571
|url-status=live
}}</ref>
<ref name="CSW Launch">{{cite web
|url=http://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=198
|title=Launch of the Computing for Sustainable Water Project
|date=2012-04-17
|publisher=World Community Grid
|access-date=2012-05-24
|archive-date=2012-05-11
|archive-url=https://web.archive.org/web/20120511192104/http://www.worldcommunitygrid.org/about_us/viewNewsArticle.do?articleId=198
|url-status=live
}}</ref>
}}

== External links ==
* {{Official website}}

{{Commons}}
{{BOINC topics}}

{{DEFAULTSORT:World Community Grid}}

[[Category:Organizations established in 2004]]
[[Category:Computer-related introductions in 2004]]
[[Category:Science in society]]
[[Category:Free science software]]
[[Category:Volunteer computing projects]]
[[Category:Philanthropic organizations based in Canada]]