Epiphanius (Template:IPAc-en; "clearly manifested") may refer to:
- Epiphanius of Petra (fl. c. 335), Arab sophist at Athens
- Saint Epiphanius of Salamis (c.310–20 to 403), bishop of Salamis, Cyprus, and author of the Panarion
- Annius Eucharius Epiphanius, praefectus urbi of the city of Rome, 412–414
- Saint Epiphanius of Pavia (438–496), Bishop of Pavia, Italy, 466–496
- Epiphanius Scholasticus (fl. c.510), translator of Greek works into Latin
- Epiphanius of Constantinople (died 535), Greek Ecumenical Patriarch of Constantinople, 520–535
- Epiphanius (Patriarch of Aquileia), first Patriarch of Aquileia to rule from Grado, Italy, 612–613
- Epiphanius the Monk (8th or 9th century), priest in the Kallistratos monastery, Constantinople
- Epiphanius the Wise (died 1420), Russian monk, hagiographer, and disciple of Saint Sergius of Radonezh
- Epiphanius Evesham (fl. 1570–c. 1623), English sculptor
- Epiphanius Slavinetsky (died 1675), ecclesiastical expert of the Russian Orthodox Church
- Epiphanius Shanov (1849–1940), Bulgarian Uniate priest
- Epiphanios of Vryoula (1935–2011), Eastern Orthodox archbishop of Spain and Portugal
- Anba Epiphanius (1954–2018), murdered Egyptian abbot of Monastery of Saint Macarius the Great
- Epiphanios of Mylopotamos (1956–2020), Greek Orthodox monk and chef at Mount Athos
- Epiphanius I of Ukraine (born 1979), elected primate of the Orthodox Church of Ukraine (since 15 December 2018) and Metropolitan of Kyiv and All Ukraine
- Places
- Monastery of Saint Epiphanius, founded by Epiphanius Scholasticus