TDB may refer to:
- Barycentric Dynamical Time (Temps Dynamique Barycentrique), a time standard
- The Daily Beast, a news site
- The Daily Buzz
- The Division Bell, a Pink Floyd album
- Trade and Development Bank, a multilateral African development financial institution
- Trade Development Bank, a former Geneva-based bank, now defunct
- Trivial Database, database engine
- United Nations Conference on Trade and Development (UNCTAD)'s Trade and Development Board
- TDB, An Australian HipHop Artist