PFS

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Patellofemoral syndrome, a type of knee disorder
Prefilled syringe, a syringe with a predetermined dosage of medication
Prefrontal synthesis, in neurology, the conscious purposeful process of synthesizing novel mental images
Progression-free survival, time without tumor progression in oncology
Post-finasteride syndrome, a term associated with adverse effects that persist beyond the discontinuation of the medication finasteride

Premium Fulfilment Services (PFS Group), National provider of 3PL solutions with operating companies in the US, UK and EU.
Penang Free School, a well-recognized English school in Malaysia, in the state of Penang
Philadelphia Folksong Society, a Philadelphia organization promoting folk music
Princeton Friends School, a coeducational Quaker school in Princeton Township, New Jersey
Property and Freedom Society, an organization devoted to the promotion of property rights

Personal finance society, a professional body for financial advisors in the United Kingdom
Personal Financial Specialist, a financial planning credential granted by the American Institute of Certified Public Accountants
Primerica Financial Services, an independent financial services company in North America

Perfect forward secrecy, a property in cryptography
pfs:Write, an early PC word processor
Planetary Fourier Spectrometer, an infrared spectrometer used by European Space Agency on their Venus Express Mission
Playstation File System, the filesystem used on the PlayStation 2 hard drive
Professional File System, a third-party filesystem used on the Amiga
PlaysForSure, a marketing certification given by Microsoft to media players
Prepare for Shipment, a status which indicates products are ready for shipment from Apple Online Store
Pre-Feasibility Study, an important preliminary study to determine if a mining project is economically feasible

Peace and Friendship Stadium, an Indoor sports Arena in Piraeus, Athens, Greece
Picture Frame Seduction, a Welsh punk rock band
Port security (Port Facility Security)
Pha̍k-fa-sṳ, an orthography designed for the Hakka Chinese language
Puta falta de sacanagem, an expression related to the Brazilian rock band Restart