TBU may refer to:
- Vought TBU Sea Wolf, a U.S. World War II torpedo bomber
- [[Fuaʻamotu International Airport|FuaTemplate:Okinaamotu International Airport]] (IATA airport code) in Tonga
- Telephone balance unit, device to convert unbalanced to balanced audio signals
- Tirana Business University a university in Albania
- Tokushima Bunri University, in Tokushima, Japan
- Tomas Bata University in Zlín, Czech Republic