TDM may refer to:
- TDM, a 2023 Indian Marathi comedy film
- TDM (Macau) ({{#invoke:Lang|lang}}), a Macanese radio and television network
- The Yamaha TDM, a motorcycle model
- Target Disk Mode, a boot mode on certain Macintosh computers
- Team deathmatch, a mode of gameplay in video games
- Technical death metal, a subgenre of heavy metal music
- {{#invoke:Lang|lang}}, a Mozambican telecommunications and Internet service provider
- Teresian Daughters of Mary, a Filipino Roman Catholic institute
- Text data mining, a process of deriving high-quality information from text
- The Difference Machine, an album by English rock band Big Big Train
- Therapeutic drug monitoring, a branch of clinical chemistry
- Time-division multiplexing, a method of transmitting and receiving independent signals over a common signal path
- Toad Data Modeler, a database design tool
- Transportation demand management, also traffic demand management or travel demand management
- DanTDM, British YouTube personality