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DET, also known under its chemical name N,N-diethyltryptamine and as T-9, is a psychedelic drug closely related to DMT and 4-HO-DET.<ref name="TiHKAL" /><ref name="titleErowid DET Vault : Chemistry">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>
DET, alongside DMT, was placed into the UN Schedule 1 list of illegal drugs in the 1970s, and is uncommon now.Template:Citation needed<ref name="Convention1971">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>
UseEdit
DET is active at an oral dose of around 50 to 100Template:Nbspmg and the effects last for about 2 to 4Template:Nbsphours.<ref name="TiHKAL">Template:CiteTiHKAL</ref><ref name="HalberstadtChathaKlein2020">Template:Cite journal</ref>
InteractionsEdit
PharmacologyEdit
PharmacodynamicsEdit
The mechanism of action of DET is thought to be serotonin receptor agonism, much like other classic psychedelics.<ref>Template:Cite journal</ref> It is a serotonin 5-HT2A receptor agonist.<ref name="BloughLandavazoDecker2014">Template:Cite journal</ref> The drug produces the head-twitch response in rodents, a behavioral proxy of psychedelic-like effects.<ref name="HalberstadtChathaKlein2020" />
PharmacokineticsEdit
Unlike DMT, DET is orally active as it is not subject to extensive metabolism by monoamine oxidase A. This may be due to the increased steric bulk of the N-ethyl substituents relative to the respective methyl groups of DMT. This is also true for many other tryptamines with larger nitrogen substituents.Template:Citation needed
ChemistryEdit
DET is a homolog of the common tryptamine hallucinogen N,N-dimethyltryptamine (DMT).
HistoryEdit
DET was first described in the scientific literature by 1959.<ref name="BoszormenyiDerNagy1959">Template:Cite journal</ref> It was first synthesized by Stephen Szára and was assessed pharmacologically by Borsi and Lenart.<ref name="BoszormenyiDerNagy1959" />
Society and cultureEdit
Legal statusEdit
InternationalEdit
Internationally DET is a Schedule I drug under the Convention on Psychotropic Substances.<ref name="Convention1971" />
AustraliaEdit
DET is considered a Schedule 9 prohibited substance in Australia under the Poisons Standard (October 2015).<ref name="Poisons Standard">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> A Schedule 9 substance is a substance which may be abused or misused, the manufacture, possession, sale or use of which should be prohibited by law except when required for medical or scientific research, or for analytical, teaching or training purposes with approval of Commonwealth and/or State or Territory Health Authorities.
ResearchEdit
Psychosis modelEdit
Early studies of DET as well as other psychedelics were focused on their presumed psychotomimetic properties.<ref name="titlePSILOCYBIN AND DIETHYLTRYPTAMINE: TWO TRYPTAMINE HALLUCINOGENS">Template:Cite journal</ref> Researchers theorized that abnormal metabolites of endogenous chemicals such as tryptamine, serotonin, and tryptophan could be the explanation for mental disorders such as schizophrenia, or psychosis.<ref name="pmid5839429">Template:Cite journal</ref> With the progression of science and pharmacological understanding, this belief has been dismissed by most researchersTemplate:Citation needed.
Mushroom productionEdit
Although DET is a synthetic compound with no known natural sources, it has been used in conjunction with the mycelium of Psilocybe cubensis to biosynthetically produce the chemicals ethocybin (4-PO-DET) and ethocin (4-HO-DET). Isolation of the alkaloids resulted in 3.3% ethocybin and 0.01-0.8% ethocin.<ref>Template:Cite journal</ref>
See alsoEdit
ReferencesEdit
External linksEdit
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