4-HO-DET

4-HO-DET, also known as 4-hydroxy-N,N-diethyltryptamine as well as ethocin or CZ-74, is a psychedelic drug of the tryptamine family.<ref name="Shulgin_1997" /> It is a substituted tryptamine, structurally related to psilocin, ethocybin, and 4-HO-DIPT.<ref name="Shulgin_1997" /><ref name = "Greene_2021">Template:Cite book</ref>

Use

TiHKAL reports moderate effects at 10 to 25Template:Nbspmg ingested orally.<ref name="Shulgin_1997">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref><ref name="HalberstadtChathaKlein2020">Template:Cite journal</ref>

Effects

4-HO-DET produces psychedelic effects similar to psilocybin.<ref name="Shulgin_1997" /> Its duration is 4 to 6Template:Nbsphours.<ref name="Shulgin_1997" />

Pharmacology

The pharmacology of 4-HO-DET has been studied.<ref name="KozellEshlemanSwanson2023">Template:Cite journal</ref>

Chemistry

Analogues

4-HO-DET is the N,N-diethyl analog of psilocin. The acetic acid ester of 4-HO-DET is known as 4-AcO-DET and the phosphoric acid ester of 4-HO-DET is known as 4-phosphoryloxy-DET, CEY-19, or ethocybin. These compounds may likely be prodrugs of 4-HO-DET as has been shown with the acetate and phosphate esters of other methylated tryptamines such as psilocin.<ref>Template:Cite journal</ref>

History

4-HO-DET received the lab code CZ-74 in the late 1950s by the inventors of the substance, Albert Hofmann and Franz Troxler. The substance was used together with its phosphoryloxy-analog ethocybin in human clinical trials in the 1960s by the German researchers Hanscarl Leuner and G. Baer.<ref name="LeunerBaer1965">Template:Cite journal</ref> It was later explored by Alexander Shulgin in his 1997 book TiHKAL.<ref>Template:CiteTiHKAL</ref>

Society and culture

Legal status

Finland

Scheduled in the "government decree on psychoactive substances banned from the consumer market".<ref>finlex.fi</ref>

Sweden

Sveriges riksdags health ministry Statens folkhälsoinstitut classified 4-HO-DET as "health hazard" under the act Lagen om förbud mot vissa hälsofarliga varor (translated Act on the Prohibition of Certain Goods Dangerous to Health) as of Nov 1, 2005, in their regulation SFS 2005:733 listed as 4-hydroxi-N,N-diethyltryptamin (4-HO-DET), making it illegal to sell or possess.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

United States

4-HO-DET is unscheduled in the United States, but purchase, sale, or possession for human consumption could be prosecuted under the Federal Analogue Act.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

External links

• 4-HO-DET - Isomer Design
• TiHKAL 4-HO-DET information at Erowid
• 4-HO-DET entry in TiHKAL • info
• Ethacetin degradation

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