EPSC can stand for:
- Elasto-Plastic Self-Consistent Modeling
- Escola Politècnica Superior de Castelldefels
- European Planetary Science Congress
- European Political Strategy Centre
- Excitatory postsynaptic current
- The European Process Safety Centre
- ICAO code of Szczecin-Goleniów "Solidarność" Airport in Poland
- Early peak systolic compliance
- European Poker Sport Championship
- Erosion Prevention & Sediment Control