Uppaluri is a Telugu surname originating from Andhra Pradesh in India.<ref>Template:Cite book</ref> They mostly belong to the class of Brahmins. Alternative spellings of this surname include Uppuluri, Vuppuluri and Vuppulury.
Notable people with the surname include:
- Subbaraya Sarma (born Uppaluri Subbaraya Sarma, 1947), Indian actor
- U. G. Krishnamurti (1918–2007), Indian philosopher
- Uppuluri Mallikarjuna Sarma (1939–2019), Indian politician
- U. S. R. Murty, Indian mathematician and professor
- Vuppuluri Ganapathi Sastry (1888–1989), Indian Sanskrit scholar, writer and spiritual teacher