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Almroth Wright

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Template:Short description Template:Use dmy dates Template:Use British English Template:Infobox scientist Sir Almroth Edward Wright Template:Post-nominals (10 August 1861 – 30 April 1947) was an English bacteriologist and immunologist.<ref>Template:Cite book</ref>

He is notable for developing a system of anti-typhoid fever inoculation, recognizing early on that antibiotics would create resistant bacteria, and being a strong advocate for preventive medicine.

BiographyEdit

Wright was born at Middleton Tyas, near Richmond, North Yorkshire into a family of mixed Anglo-Irish and Swedish descent.<ref name="Michael Worboys 1947">Michael Worboys, 'Wright, Sir Almroth Edward (1861–1947)', Template:Cite ODNB</ref> He was the son of Reverend Charles Henry Hamilton Wright, deacon of Middleton Tyas, who later served in Belfast, Dublin, and Liverpool and managed the Protestant Reformation Society.<ref>Template:Cite news</ref> His mother, Ebba Almroth, was the daughter of Template:Interlanguage link multi, Governor of the Swedish Royal Mint in Stockholm.<ref name=OB>Sir Charles Hagberg Wright (obituary) Template:Webarchive. The Times, 7 March 1940.</ref> His younger brother Charles Theodore Hagberg Wright became the librarian of the London Library.

In 1882, he graduated from Trinity College Dublin with first-class honours in modern literature and won a gold medal in modern languages and literature.<ref name="ZC-AW:FoMVT">Template:Cite book</ref>Template:Rp Simultaneously he took medicine courses and in 1883 graduated in medicine.<ref name=frs /><ref name=ZC-AW:FoMVT />Template:Rp In the late 19th century, Wright worked with the armed forces of Britain to develop vaccines and promote immunisation.

He married Jane Georgina Wilson (1861-1926)<ref name="Michael Worboys 1947"/> in 1889 and had three children. The first, Edward Robert Mackay Wright (1890–1913), was born in Glebe, Sydney. Second son Leonard Almoth Wilson Wright (1891–1972) was born in Dublin, as was daughter Doris Helena MacNaughton Wright (later Romanes, after whom the Helena Romanes School was named) (1894–1990).<ref>England and Wales, National Probate Calendar (Index of Wills and Administrations), 1858-1995 for Almoth Edward Wright</ref>

In 1902, Wright started a research department at St Mary's Hospital Medical School in London. He developed a system of anti-typhoid fever inoculation and brought the humoral and cellular theories of immunity together by showing the cooperation of a substance (that he named opsonin) contained in the serum with the phagocytes against pathogens.<ref>Template:Cite journal</ref> Citing the example of the Second Boer War, during which many soldiers died from easily preventable diseases, Wright convinced the armed forces that 10 million vaccine doses for the troops in northern France should be produced during World War I. During WWI Wright established a research laboratory attached to the British Expeditionary Force's hospital designated Number 13, General Hospital in Boulogne-sur-Mer.<ref>Template:Cite journal</ref> In 1919, Wright returned to St Mary's and remained there until his retirement in 1946. Among the many bacteriologists who followed in Wright's footsteps at St Mary's was Sir Alexander Fleming, who in turn later discovered lysozyme and penicillin. Wright was elected a Fellow of the Royal Society in May 1906.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> Leonard Colebrook became his assistant in 1907 and continued working with him until 1929.<ref name="frs2">Template:Cite journal</ref>

Wright warned early on that antibiotics would create resistant bacteria,<ref name=ZC-AW:FoMVT />Template:Rp something that has proven an increasing danger. He made his thoughts on preventive medicine influential, stressing preventive measures. Wright's ideas have been re-asserted recently—70 years after his death—by modern researchers in articles in such periodicals as Scientific American. He also argued that microorganisms are vehicles of disease but not its cause, a theory that earned him the nickname "Almroth Wrong" from his opponents. Another derogatory nickname was "Sir Almost Wright".<ref name = "sal">Template:Cite book</ref>

He also proposed that logic be introduced as a part of medical training, but his idea was never adopted. Wright also pointed out that Pasteur and Fleming, although both excellent researchers, had not managed to find cures for the diseases for which they had sought cures, but instead had stumbled upon cures for totally unrelated diseases.Template:Citation needed

Wright was a strong proponent of the Ptomaine theory for the cause of Scurvy.<ref>Template:Cite journal</ref> The theory was that poorly preserved meats contained alkaloids that were poisonous to humans when consumed. This theory was prevalent when Robert Falcon Scott planned his fateful expedition to the Antarctic in 1911. In 1932, the true cause of the disease was determined to be the deficiency from the diet of a particular nutrient, now called Vitamin C (Ascorbic acid, Scorbic meaning Scurvy).Template:Citation needed

There is a ward named after him at St Mary's Hospital, Paddington, London.Template:Citation needed

Women's suffrageEdit

Wright was strongly opposed to women's suffrage. He argued that women's brains were innately different from men's and were not constituted to deal with social and public issues. His arguments were most fully expounded in his book The Unexpurgated Case Against Woman Suffrage (1913). In the book, Wright also vigorously opposes the professional development of women.<ref name="cpg">Template:Cite book</ref> Rebecca West and May Sinclair both wrote articles criticizing Wright's opposition to women's suffrage.<ref>Template:Cite book</ref><ref>Template:Cite book</ref> Charlotte Perkins Gilman satirized Wright's opposition to women's suffrage in her novel Herland.<ref name="cpg" />

Bernard ShawEdit

Wright was a friend of his fellow Irishman George Bernard Shaw. He was immortalised as Sir Colenso Ridgeon in the play The Doctor's Dilemma written in 1906, which arose from conversations between Shaw and Wright. Shaw credits Wright as the source of his information on medical science: "It will be evident to all experts that my play could not have been written but for the work done by Sir Almroth Wright on the theory and practice of securing immunization from bacterial diseases by the inoculation of vaccines made of their own bacteria."<ref>Violet M. Broad & C. Lewis Broad, Dictionary to the Plays and Novels of Bernard Shaw, A. & C. Black, London, 1929, p.41.</ref> This remark of Shaw's is characteristically ironical. Wright was knighted shortly before the play was written, and Shaw was suspicious of Wright's high reputation (the latter was also known by the nickname Sir Almost Right). The two men met in 1905, and engaged in a long series of robust discussions, involving at one point a challenge from the medical audience that they had "too many patients on our hands already". Shaw's response was to ask what would be done if there was more demand from patients than could be satisfied, and Wright answered: "We should have to consider which life was worth saving." This became the "dilemma" of the play.<ref>Michael Holroyd, The Guardian 13 July 2012, "Bernard Shaw and his lethally absurd doctor's dilemma".</ref>

Shaw also portrays him in his playlet How These Doctors Love One Another! and uses his theory of bacterial mutation in Too True to Be Good.<ref name = "sal"/> Shaw, who campaigned for women's suffrage, strongly disagreed with Wright about women's brains and dismissed his views on the subject as absurd.Template:Citation needed

AwardsEdit

Wright had been honoured for his deeds a total of 29 times in his lifetime – a knighthood, 5 honorary doctorates, 5 honorary orders, 6 fellowships (2 honoraries), 4 prizes, 4 memberships, and 3 medals (Buchanan Medal, Fothergill Gold Medal and a special medal "for the best medical work in connection with the war").<ref name="LCAWPDT">Template:Cite book</ref>Template:Rp He was nominated 14 times for the Nobel prize from 1906 to 1925.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

WorksEdit

Template:Sister projectTemplate:Namespace detectWright's work could be split up into the following three phases

  • Early phase (1891–1910) – over 20 medical journal publications, lectures for students and other scientific works
    • Upon a new septic (1891)
    • On the conditions which determine the distribution of the coagulation (1891)
    • A new method of blood transfusion (1891)
    • Grocers' research scholarship lectures (1891)
    • Lecture on tissue- or cell-fibrinogen (1892)
    • On the leucocytes of peptone and other varieties of liquid extravascular blood (1893)
    • On Haffkine's method of vaccination against Asiatic cholera (1893, coauthored with D. Bruce)
    • Remarks on methods of increasing and diminishing the coagulability of the blood (1894)
    • On the association of serious haemorrhages (1896)
    • A suggestion as to the possible cause of the corona observed in certain after images (1897)
    • On the application of the serum test to the differential diagnosis of typhoid and Malta fever (1897)
    • Remarks on vaccination against typhoid fever (1897, coauthored with D. Semple)
    • An experimental investigation on the role of the blood fluids in connection with phagocytosis (1903, coauthored with Stewart Rankin Douglas)
    • On the action exerted upon the tubercle bacillus by human blood fluids (1904, coauthored with Stewart Rankin Douglas)
    • A short treatise on anti-typhoid inoculation (1904)
    • On the possibility of determining the presence or absence of tubercular infection (1906, coauthored with S. T. Reid)
    • On spontaneous phagocytosis (1906, coauthored with S. T. Reid)
    • Studies on immunisation and their application to the diagnosis and treatment of bacterial infections (1909)
    • Vaccine therapy—its administration, value, and limitations (1910)
    • Introduction to vaccine therapy (1920)
  • War phases (1914–1918 and 1941–1945) – mostly works about wounds, wound infections and new perspectives on the topic
    • Wound infections and some new methods (1915)
    • Conditions which govern the growth of the bacillus of "Gas Gangrene" (1917)
    • Pathology and Treatment of War Wounds (1942)
    • Researches in Clinical Physiology (1943)
    • Studies on Immunization (2 vol., 1943–1944)
  • Philosophy phase (1918–1941 and 1945–1947) – more or less philosophic works, including thoughts on logic, equality, science and scientific methods
  • Handbooks
    • Principles of microscopy: being a handbook to the microscope (1906)
    • Technique of the teat and capillary glass tube (1912)

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