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In telecommunications, bit-sequence independence is a characteristic of some digital data transmission<ref name="Clark">A. P. Clark, "Principles of Digital Data Transmission", Published by Wiley, 1983</ref> as well as digital transmission<ref>David R. Smith, "Digital Transmission Systems", Kluwer International Publishers, 2003, Template:ISBN. See table-of-contents.</ref> systems that impose no restrictions on, or modification of, the transmitted bit sequence.

Bit-sequence-independent protocols are in contrast to protocols that reserve certain bit sequences for special meanings, such as the flag sequence, 01111110, for HDLC, SDLC, and ADCCP protocols.

Bit-sequence-independence allows only line codes that have the same number of transitions per bit, otherwise, the line code is dependent on the bit sequence and, therefore, bit-sequence dependent.

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