Bombesin

Template:Chembox Bombesin is a 14-amino acid peptide<ref name="pmid18185064">Template:Cite journal</ref> originally isolated from the skin of the European fire-bellied toad (Bombina bombina)<ref name="Anastasi-et-al-1971-bundle"> Template:Unbulleted list citebundle </ref> by Vittorio Erspamer et al. and named after its source.<ref name="Jensen-et-al-2007">Template:Cite journal NIHMSID 45053.</ref> It has two known homologs in mammals called neuromedin B and gastrin-releasing peptide. It stimulates gastrin release from G cells. It activates three different G-protein-coupled receptors known as BBR1, -2, and -3.<ref name="pmid19115523">Template:Cite journal</ref> It also activates these receptors in the brain. Together with cholecystokinin, it is the second major source of negative feedback signals that stop eating behaviour.<ref name="pmid11127929">Template:Cite journal</ref>

Bombesin is also a tumor marker for small cell carcinoma of lung, gastric cancer, pancreatic cancer, and neuroblastoma.<ref name="pmid10636070">Template:Cite journal</ref>

Receptors

The anuran Template:Visible anchor receptor homologue is termed Template:Visible anchor (Template:Visible anchor).<ref name="Jensen-et-al-2007" /> Iwabuchi et al. 2003 discovered a chicken (Gallus domesticus) receptor which is homologous to both the Template:Visible anchor and fBB₄ and so they named it Template:Visible anchor.<ref name="Jensen-et-al-2007" />

Effects

Erspamer 1988 finds bombesin has a similar effect on the chicken to ranatensin, unreliably increasing or decreasing blood pressure.<ref name="Erspamer-1988-bundle"> Template:Unbulleted list citebundle</ref>

See also

• Gastrin-releasing peptide
• Neuromedin B
• Neuromedin U