Endocarditis

Endocarditis is an inflammation of the inner layer of the heart, the endocardium. It usually involves the heart valves. Other structures that may be involved include the interventricular septum, the chordae tendineae, the mural endocardium, or the surfaces of intracardiac devices. Endocarditis is characterized by lesions, known as vegetations, which are masses of platelets, fibrin, microcolonies of microorganisms, and scant inflammatory cells.<ref name=Harrison>Template:Cite book</ref> In the subacute form of infective endocarditis, a vegetation may also include a center of granulomatous tissue, which may fibrose or calcify.<ref name=Robbins>Template:Cite book</ref>

There are several ways to classify endocarditis. The simplest classification is based on cause: either infective or non-infective, depending on whether a microorganism is the source of the inflammation or not. Regardless, the diagnosis of endocarditis is based on clinical features, investigations such as an echocardiogram, and blood cultures demonstrating the presence of endocarditis-causing microorganisms.

Signs and symptoms include fever, chills, sweating, malaise, weakness, anorexia, weight loss, splenomegaly, flu-like feeling, cardiac murmur, heart failure, petechia (red spots on the skin), Osler's nodes (subcutaneous nodules found on hands and feet), Janeway lesions (nodular lesions on palms and soles), and Roth's spots (retinal hemorrhages).

Infective endocarditis

{{#invoke:Labelled list hatnote|labelledList|Main article|Main articles|Main page|Main pages}} Infective endocarditis is an infection of the inner surface of the heart, usually the valves.<ref name=Mer2017/> Symptoms may include fever, small areas of bleeding into the skin, heart murmur, feeling tired, and low red blood cells.<ref name=Mer2017>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> Complications may include valvular insufficiency, heart failure, stroke, and kidney failure.<ref name=Nj2017>Template:Cite journal</ref><ref name=Mer2017/>

The cause is typically a bacterial infection and less commonly a fungal infection.<ref name=Mer2017/> Risk factors include valvular heart disease including rheumatic disease, congenital heart disease, artificial valves, hemodialysis, intravenous drug use, and electronic pacemakers.<ref name=Amb2017/> The bacteria most commonly involved are streptococci or staphylococci.<ref name=Mer2017/>

The diagnosis of infective endocarditis relies on the Duke criteria, which were originally described in 1994 and modified in 2000. Clinical features and microbiological examinations are the first steps to diagnose an infective endocarditis. The imaging is also crucial. Echocardiography is the cornerstone of imaging modality in the diagnosis of infective endocarditis. Alternative imaging modalities as computer tomography, magnetic resonance imaging, and positron emission tomography/computer tomography (PET/CT) with 2-[18F]fluorodeoxyglucose (FDG) are playing an increasing role in the diagnosis and management of infective endocarditis.<ref>Template:Cite journal</ref>

The usefulness of antibiotics following dental procedures has changed over time.<ref>Template:Cite journal</ref> Prevention is recommended in patients at high risk.<ref name=Mer2017/> Treatment is generally with intravenous antibiotics.<ref name=Mer2017/> The choice of antibiotics is based on the blood cultures.<ref name=Mer2017/> Occasionally heart surgery is required.<ref name=Mer2017/><ref>Template:Cite journal</ref> Populations at high risk of infective endocarditis include patients with previous infective endocarditis, patients with surgical or transcatheter prosthetic valves or post-cardiac valve repair, and patients with untreated CHD and surgically corrected congenital heart disease.<ref>Template:Cite journal</ref><ref>Template:Cite journal</ref>

The number of people affected is about 5 per 100,000 per year.<ref name=Amb2017/> Rates, however, vary between regions of the world.<ref name=Amb2017/> Males are affected more often than females.<ref name=Mer2017/> The risk of death among those infected is about 25%.<ref name=Amb2017>Template:Cite journal</ref> Without treatment it is almost universally fatal.<ref name=Mer2017/>

Non-infective endocarditis

{{#invoke:Labelled list hatnote|labelledList|Main article|Main articles|Main page|Main pages}} Nonbacterial thrombotic endocarditis (NBTE) is most commonly found on previously undamaged valves.<ref name=Robbins/> As opposed to infective endocarditis, the vegetations in NBTE are small, sterile, and tend to aggregate along the edges of the valve or the cusps.<ref name=Robbins/> Also unlike infective endocarditis, NBTE does not cause an inflammation response from the body.<ref name=Robbins/> NBTE usually occurs during a hypercoagulable state such as system-wide bacterial infection, or pregnancy, though it is also sometimes seen in patients with venous catheters.<ref name=Robbins/> NBTE may also occur in patients with cancer, particularly mucinous adenocarcinoma<ref name=Robbins/> where Trousseau syndrome can be encountered. Typically NBTE does not cause many problems on its own, but parts of the vegetations may break off and embolize to the heart or brain, or they may serve as a focus where bacteria can lodge, thus causing infective endocarditis.<ref name=Robbins/>

Another form of sterile endocarditis is termed Libman–Sacks endocarditis; this form occurs more often in patients with lupus erythematosus and is thought to be due to the deposition of immune complexes.<ref name=Robbins/> Like NBTE, Libman-Sacks endocarditis involves small vegetations, while infective endocarditis is composed of large vegetations.<ref name=Robbins/> These immune complexes precipitate an inflammation reaction, which helps to differentiate it from NBTE. Also unlike NBTE, Libman-Sacks endocarditis does not seem to have a preferred location of deposition and may form on the undersurfaces of the valves or even on the endocardium.<ref name=Robbins/>

Further reading

• Template:Cite journal
• Template:Cite journal