Expressome may refer to:

  • A supramolecular complex consisting of RNA polymerase and a trailing ribosome linked by a shared mRNA. The expressome complex mediates a mechanism of gene expression regulation termed transcription-translation coupling.<ref name="Kohler2017" /><ref name="Webster2020" /><ref name="OReilly2020" />
  • The whole set of gene expression in a cell, tissue, organ, organisms, and species. Expressome is a slightly larger concept than transcriptome. The transcriptome is the set of transcripts, while expressome includes transcripts, proteins and other ligands (abundance or concentration).

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