Frovatriptan

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| _other_data=(+)-(R)-3-Methylamino-6-carboxamido-1,2,3,4-tetrahydrocarbazole

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Frovatriptan, sold under the brand name Frova, is a triptan medication developed by Vernalis for the treatment of migraine headaches<ref name="pmid27757013">Template:Cite journal</ref> and for short term prevention of menstrual migraine.<ref name="pmid24904224">Template:Cite journal</ref> The product is licensed to Endo Pharmaceuticals in North America and Menarini in Europe.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

Medical uses

Frovatriptan is used in the treatment of migraine.

Available forms

It is available as 2.5 mg tablets.

Contraindications

Frovatriptan should not be given to patients with:

• Ischemic heart disease
• Cerebrovascular syndrome
• Peripheral vascular disease
• Uncontrolled hypertension
• Hemiplegic or basilar migraine

Side effects

Rare, but serious cardiac events have been reported in patients with risk factors predictive of CAD. These include: coronary artery vasospasm, transient myocardial ischemia, myocardial infarction, ventricular tachycardia and ventricular fibrillation.

Pharmacology

Pharmacodynamics

Frovatriptan is a serotonin receptor agonist, with high affinity for the 5-HT_1B/1D receptors. It has no significant effects on the GABA_A mediated channel activity and benzodiazepine binding sites. Frovatriptan inhibits excessive dilation of arteries that supply blood to the head.

Pharmacokinetics

Frovatriptan has a terminal elimination half-life of approximately 26 hours, making it the longest within its class.<ref>Template:Cite journal</ref>

Society and culture

Legal status

Frovatriptan is available only by prescription in the United States and Canada.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

References

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