Hydrocortisone

Hydrocortisone is the name for the hormone cortisol when supplied as a medication.<ref>Template:Cite book</ref> It is a corticosteroid and works as an anti-inflammatory and by immune suppression.<ref name="AHFS2016" /> Uses include conditions such as adrenocortical insufficiency, adrenogenital syndrome, high blood calcium, thyroiditis, rheumatoid arthritis, dermatitis, asthma, and COPD.<ref name="AHFS2016">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> It is the treatment of choice for adrenocortical insufficiency.<ref name="Ric2015">Template:Cite book</ref> It can be given by mouth, topically, or by injection.<ref name="AHFS2016" /> Stopping treatment after long-term use should be done slowly.<ref name="AHFS2016" />

Side effects may include mood changes, increased risk of infection, and edema (swelling).<ref name="AHFS2016" /> With long-term use, common side effects include osteoporosis, upset stomach, physical weakness, easy bruising, and candidiasis (yeast infections).<ref name="AHFS2016" /> It is unclear if it is safe for use during pregnancy.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

Hydrocortisone was patented in 1936 and approved for medical use in 1941.<ref>{{#if:2183589 |[{{#ifeq:|uspto|http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=%7Chttps://patents.google.com/patent/US}}{{#iferror:{{#expr:2183589 }}|2183589}} U.S. patent {{#ifeq:Template:Replace|Template:Digits|Template:Replace|2183589}}] |{{US patent|123456|link text}}}}</ref><ref name=Fis2006>Template:Cite book</ref> It is on the World Health Organization's List of Essential Medicines.<ref name="WHO21st">Template:Cite book</ref> It is available as a generic medication.<ref name=AHFS2016/> In 2022, it was the 202nd most commonly prescribed medication in the United States, with more than 2Template:Nbspmillion prescriptions.<ref name="Top 300 of 2022">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref><ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

Medical uses

Hydrocortisone is the pharmaceutical term for cortisol used in oral administration, intravenous injection, or topical application. It is used as an immunosuppressive drug, given by injection in the treatment of severe allergic reactions such as anaphylaxis and angioedema, in place of prednisolone in patients needing steroid treatment but unable to take oral medication, and perioperatively in patients on long-term steroid treatment to prevent an adrenal crisis. It may also be injected into inflamed joints resulting from diseases such as gout.Template:Cn

It may be used topically for allergic rashes, eczema, psoriasis, itching, and other inflammatory skin conditions. Topical hydrocortisone creams and ointments are available in most countries without prescription in strengths ranging from 0.05% to 2.5% (depending on local regulations) with stronger forms available by prescription only.Template:Citation needed

It may also be used rectally in suppositories to relieve the swelling, itch, and irritation in hemorrhoids.<ref name="anusol-acetate"/>

It may be used as an acetate form (hydrocortisone acetate), which has slightly different pharmacokinetics and pharmacodynamics.<ref name="anusol-acetate"/><ref name="pmid18345402">Template:Cite journal</ref>

• Cortisol for injection.jpg

  Cortisol for injection

• Tube of hydrocortisone cream.jpg

  A tube of hydrocortisone cream, purchased over-the-counter

• Hydrocortisone Cortef 10 mg Кортеф Гидрокортизон.jpg

  Hydrocortisone 10 mg oral tablets (depicted a package for Russian market)

Pharmacology

Pharmacodynamics

Hydrocortisone is a corticosteroid, acting specifically as both a glucocorticoid and as a mineralocorticoid. That is, it is an agonist of the glucocorticoid and mineralocorticoid receptors.Template:Cn

Hydrocortisone has low potency relative to synthetic corticosteroids.<ref name="pmid23947590">Template:Cite journal</ref> Compared to hydrocortisone, prednisolone is about 4Template:Nbsptimes as potent and dexamethasone about 40Template:Nbsptimes as potent in terms of anti-inflammatory effect.<ref name=Dexamethasone>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> Prednisolone can also be used as cortisol replacement, and at replacement dose levels (rather than anti-inflammatory levels), prednisolone is about 8Template:Nbsptimes more potent than cortisol.<ref>Template:Cite journal</ref> The equivalent doses and relative potencies of hydrocortisone compared to various other synthetic corticosteroids have also been reviewed and summarized.<ref name="pmid23947590" />

The endogenous production rate of cortisol is approximately 5.7 to 9.9Template:Nbspmg/m² per day, which corresponds to an oral hydrocortisone dose of approximately 15 to 20Template:Nbspmg/day (for a 70-kg person).<ref name="Arvat Falorni 2016 p. 1-PA61">Template:Cite book</ref><ref name="GhizzoniCappaChrousos2011">Template:Cite book</ref> One review described daily cortisol production of 10Template:Nbspmg in healthy volunteers and reported that daily cortisol production could increase up to 400Template:Nbspmg in conditions of severe stress (e.g., surgery).<ref name="pmid15634032" />

The total and/or free concentrations of cortisol/hydrocortisone required for various glucocorticoid effects have been determined.<ref name="pmid15634032" />

Pharmacokinetics

Absorption

The bioavailability of oral hydrocortisone is about 96% ± 20% (SD).<ref name="pmid15634032" /><ref name="pmid18611115" /> The pharmacokinetics of hydrocortisone are non-linear.<ref name="pmid15634032" /> The peak level of oral hydrocortisone is 15.3 ± 2.9 (SD) μg/L per 1Template:Nbspmg dose.<ref name="pmid15634032" /> The time to peak concentrations of oral hydrocortisone is 1.2 ± 0.4 (SD) hours.<ref name="pmid15634032" />

The topical percutaneous absorption of hydrocortisone varies widely depending on experimental circumstances and has been reported to range from 0.5 to 14.9% in different studies.<ref name="pmid8299376">Template:Cite journal</ref> Some skin application sites, like the scrotum and vulva, absorb hydrocortisone much more efficiently than other application sites, like the forearm.<ref name="pmid8299376" /><ref name="pmid32643443">Template:Cite journal</ref><ref name="WesterMaibach2021">Template:Cite book</ref> In one study, the amount of hydrocortisone absorbed ranged from 0.2% to 36.2% depending on the application site, with the ball of the foot having the lowest absorption and the scrotum having the highest absorption.<ref name="WesterMaibach2021" /> The absorption of hydrocortisone by the vulva has ranged from 4.4 to 8.1%, relative to 1.3 to 2.8% for the arm, in different studies and subjects.<ref name="WesterMaibach2021" /><ref name="pmid7406539">Template:Cite journal</ref><ref name="pmid8746334">Template:Cite journal</ref>

Distribution

Most cortisol in the blood (all but about 4%) is bound to proteins, including corticosteroid binding globulin (CBG) and serum albumin. A pharmacokinetic review stated that 92% ± 2% (SD) (92–93%) of hydrocortisone is plasma protein-bound.<ref name="pmid15634032" /> Free cortisol passes easily through cellular membranes.<ref>Template:Cite journal</ref> Inside cells it interacts with corticosteroid receptors.<ref name="isbn1-4377-1753-5">Template:Cite book</ref>

Metabolism

Hydrocortisone is metabolized by 11β-hydroxysteroid dehydrogenases (11β-HSDs) into cortisone, an inactive metabolite.<ref name="pmid18611115" /><ref name="pmid15634032" /> It is additionally 5α-, 5β-, and 3α-reduced into dihydrocortisols, dihydrocortisones, tetrahydrocortisols, and tetrahydrocortisones.<ref name="pmid33418075">Template:Cite journal</ref><ref name="pmid15634032" /><ref name="pmid18611115" />

Elimination

The elimination half-life of hydrocortisone ranges from about 1.2 to 2.0 (SD) hours, with an average of around 1.5Template:Nbsphours, regardless of oral versus parenteral administration.<ref name="pmid15634032" /><ref name="pmid18611115" /> The duration of action of systemic hydrocortisone has been listed as 8 to 12Template:Nbsphours.<ref name="pmid23947590" />

Chemistry

Hydrocortisone, also known as 11β,17α,21-trihydroxypregn-4-ene-3,20-dione, is a naturally occurring pregnane steroid.<ref name="Elks2014">Template:Cite book</ref><ref name="IndexNominum2000">Template:Cite book</ref> A variety of hydrocortisone esters exist and have been marketed for medical use.<ref name="Elks2014" /><ref name="IndexNominum2000" />

Society and culture

Legal status

In March 2021, the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) adopted a positive opinion, recommending the granting of a marketing authorization for the medicinal product Efmody, intended for the treatment of congenital adrenal hyperplasia (CAH) in people aged twelve years and older.<ref name="Efmody: Pending EC decision" /> The applicant for this medicinal product is Diurnal Europe BV.<ref name="Efmody: Pending EC decision">{{#invoke:citation/CS1|citation |CitationClass=web }} Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.</ref> Hydrocortisone (Efmody) was approved for medical use in the European Union, in May 2021, for the treatment of congenital adrenal hyperplasia (CAH) in people aged twelve years and older.<ref name="Efmody EPAR">{{#invoke:citation/CS1|citation |CitationClass=web }} Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.</ref>

Anti-competitive practices

In the UK, the Competition and Markets Authority (CMA) concluded an investigation into the supply of hydrocortisone tablets, finding that from October 2008 onwards, drug suppliers Auden McKenzie and Actavis plc had charged "excessive and unfair prices" for 10mg and 20mg tablets and entered into agreements with potential competitors, paying companies who agreed not to enter the hydrocortisone market and enabling Auden McKenzie and Actavis to supply the drugs as "generic" rather than branded products and thereby escape price controls until eventually other companies entered the market. Auden and Actavis overcharged the UK's National Health Service for over ten years. Fines totalling over £255m were levied against the companies involved in this breach of competition law.<ref>Template:OGL-attribution</ref>

Research

COVID-19

Hydrocortisone was found to be effective in reducing mortality rate of critically ill COVID-19 patients when compared to other usual care or a placebo.<ref>Template:Cite journal</ref>