Multisystem developmental disorder

Multisystem developmental disorder (MSDD) is a term used by Stanley Greenspan to describe children under age 3 who exhibit signs of impaired communication as in autism, but with strong emotional attachments atypical of autism.Template:Citation needed It is described in the DC:0-3R manual as an optional diagnosis for children under two years of age.<ref>Template:Cite journal</ref><ref name="Oztop 2007">Template:Cite journal</ref>

Other uses of the term

The term multisystem developmental disorder has also been used to describe various developmental disorders. These include:

• Alagille syndrome,<ref name=a>Template:Cite journal</ref> an autosomal dominant disorder with a wide range of features and manifestations. Its five most significant features are chronic cholestasis, a condition where bile cannot flow from the liver to the duodenum, occurring in 95% of cases; heart abnormalities (over 90%); butterfly vertebrae; posterior embryotoxon and a distinctive face (prominent forehead, deep-set eyes, and a pointed chin).<ref>Template:Cite journal</ref>
• Rubinstein-Taybi syndrome,<ref name=rt>Template:Cite journal</ref><ref>{{#invoke:citation/CS1|citation

|CitationClass=web }}</ref> a syndrome characterized by broad thumbs, facial abnormalities, and big toes alongside moderate to severe intellectual disability.<ref>Template:Cite journal</ref>

• Williams syndrome,<ref name=w>Template:Cite journal</ref><ref name=wb>Template:Cite journal</ref> a neurodevelopmental disorder characterized by a unique profile of strengths and deficits; most with the condition have mild intellectual disability but have grammatical and lexical abilities above what would be expected from their IQs.<ref>Template:Cite book</ref> They are hypersocial and empathetic, but social isolation is commonly experienced.<ref>Template:Cite book</ref>
• Proteus syndrome,<ref>Template:Cite journal</ref> a congenital disorder causing disproportionate growth of skin, bone, and other tissues.<ref>Template:Cite journal</ref>
• Asphyxiating thoracic dysplasia,<ref>Template:Cite journal</ref> an autosomal recessive skeletal disorder with an estimated prevalence of between 1 in 100,000 and 1 in 130,000 live births.<ref>Template:Cite journal</ref>

Symptoms

• Toe walking<ref name="Woliver2009">Template:Cite book</ref>
• Pragmatic speech problems<ref name="Woliver2009" />
• Clumsiness<ref name="Woliver2009" />
• Obsessions and rituals<ref name="Woliver2009" />
• Sensory issues<ref name="Woliver2009" />
• Disinterest in social interaction<ref name="Woliver2009" />
• Autistic characteristics<ref name="Woliver2009" />

Further reading

• Template:Cite journal
• Increasing Interaction with Children with Multisystem Developmental Disorder (MSDD), Developmental Delay Resources
• Template:Cite journal