Splenocyte
Template:Cs1 config Splenocytes are white blood cells that reside in the spleen and are involved in functions of the spleen, such as filtering blood and the immune response.<ref name="Cleveland_Clinic">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>
Splenocytes consist of a variety of cell populations such as T and B lymphocytes, dendritic cells and macrophages, which have different immune functions.<ref name="Bronte_2013">Template:Cite journal</ref>
OverviewEdit
Splenocytes are spleen cells and consist of leukocytes like B and T cells, dendritic cells, and macrophages.<ref name="Bronte_2013" /> The spleen is split into red and white pulp regions with the marginal zone separating the two areas. The red pulp is involved with filtering blood and recycling iron, while the white pulp is involved in the immune response.<ref name="Bronte_2013" />
The red pulp contains macrophages that phagocytose old or damaged red blood cells.<ref name="Cleveland_Clinic" />
The white pulp contains separate compartments for B and T cells called the B cell zone (BCZ) and the T cell zone (TCZ).<ref name="Lewis_2019">Template:Cite journal</ref> B cells make antibodies to fight off bacterial, viral, and fungal infections, and T cells are activated in response to antigens.<ref name="Cleveland_Clinic" /><ref name="Bronte_2013" /><ref name="Lewis_2019" />
The marginal zone (MZ) separates the red and white pulp regions and contains macrophages, B cells, and dendritic cells. MZ macrophages remove some types of blood-borne bacteria and viruses.<ref name="Bronte_2013" /> MZ B and dendritic cells are involved in antigen processing and presentation to lymphocytes in the white pulp.<ref name="Bronte_2013" />
ReferencesEdit
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