Tolnaftate

Template:Short description Template:Drugbox Tolnaftate (INN),<ref name="INN" /> sold under the brand name TAGRID, among others, is a synthetic thiocarbamate used as an anti-fungal agent that may be sold without medical prescription in most jurisdictions. It is supplied as a cream, powder, spray, liquid, and liquid aerosol.<ref name=":1" /> Tolnaftate is used to treat fungal conditions such as jock itch, athlete's foot and ringworm.<ref name=":1">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

Mechanism

Although the exact mechanism of action is not entirely known, it is believed to inhibit squalene epoxidase,<ref name="pmid3524433">Template:Cite journal</ref> an important enzyme in the biosynthetic pathway of ergosterol (a key component of the fungal cell membrane) in a similar way to terbinafine.<ref name="urlantifung">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

Uses

Tolnaftate has been found to be generally slightly less effective than azoles when used to treat tinea pedis (athlete's foot). It is, however, useful when dealing with ringworm, especially when passed from pets to humans.<ref>Crawford F, Hart R, Bell-Syer S, Torgerson D, Young P, Russell I. Topical treatments for fungal infections of the skin and nails of the foot (Cochrane Review). In: The Cochrane Library, Issue 1, 2003. Oxford: Update Software.</ref>

Side effects

Side effects that may occur include:<ref name=":0">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

• allergic reactions like:
  • skin rash
  • itching or hives
  • swelling of the face, lips, or tongue
• inflammation, redness, or pain at the affected area

Less severe side effects include:<ref name=":0" />

• dry skin
• mild skin irritation, burning, or itching at the affected area

See also

• Liranaftate, a similar thiocarbamate antifungal

External links

• Medline's entry for tolnaftate
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