Editing Peyer's patch (section)

==Clinical significance==
Although important in the immune response, excessive growth of lymphoid tissue in Peyer's patches is pathologic, as [[Organ hypertrophy|hypertrophy]] of Peyer's patches has been closely associated with idiopathic [[intussusception (medical disorder)|intussusception]].

Having too many or larger than normal Peyer's patches is associated with an increased risk of [[prion disease]]s, and [[intussusception (medical disorder)|intussusception]] in children. A history of viral illness is a risk factor for enlarged or inflamed Peyer's patches.<ref>{{Cite book |last=MD |first=Steven M. Fiser |title=The ABSITE Review |date=2022-08-30 |publisher=LWW |isbn=978-1-9751-9029-3 |edition=7th |language=English}}</ref>

''[[Salmonella|Salmonella typhi]]'' and [[poliovirus]] also target this section of the intestine.<ref name=BMJ />

Disturbances in the gut microbiota and immune regulation within Peyer's patches are implicated in the pathogenesis of autoimmune diseases, such as Crohn's disease, where chronic inflammation can arise due to overactive immune responses.<ref name=C/> As Peyer's patches are packed with immune cells and produce protective proteins such as secretory IgA to maintain gut balance, their dysfunction can trigger inappropriate immune responses, driving the inflammation and tissue damage characteristic of autoimmune diseases.<ref>{{Cite journal |last1=Abo-Shaban |first1=T. |last2=Sharna |first2=S. S. |last3=Hosie |first3=S. |last4=Lee |first4=C. Y. Q. |last5=Balasuriya |first5=G. K. |last6=McKeown |first6=S. J. |last7=Franks |first7=A. E. |last8=Hill-Yardin |first8=E. L. |date=2023-03-01 |title=Issues for patchy tissues: defining roles for gut-associated lymphoid tissue in neurodevelopment and disease |journal=Journal of Neural Transmission |language=en |volume=130 |issue=3 |pages=269–280 |doi=10.1007/s00702-022-02561-x |issn=1435-1463 |pmc=10033573 |pmid=36309872}}</ref>