Peyer's patch

Template:Short description Template:Infobox lymph Peyer's patches or aggregated lymphoid nodules are organized lymphoid follicles, named after the 17th-century Swiss anatomist Johann Conrad Peyer.<ref name = "Peyer" >Template:Cite book

• Reprinted as: Template:Cite book
• Peyer referred to Peyer's patches as plexus or agmina glandularum (clusters of glands). From (Peyer, 1681), p. 7: "Tenui a perfectiorum animalium Intestina accuratius perlustranti, crebra hinc inde, variis intervallis, corpusculorum glandulosorum Agmina sive Plexus se produnt, diversae Magnitudinis atque Figurae." (I knew from careful study of more advanced animals, the intestines bear — often here and there, at various intervals — clusters of glandular small bodies or "plexuses" of diverse size and shape.) From p. 15: "(has Plexus seu agmina Glandularum voco)" (I call them "plexuses" or clusters of glands) He described their appearance. From p. 8: "Horum vero Plexuum facies modo in orbem concinnata; modo in Ovi aut Olivae oblongam, aliamve angulosam ac magis anomalam disposita figuram cernitur." (But the configurations of these "plexuses" are arranged at one time in a circle; at another time, it is seen in an egg [shape] or an oblong olive [shape] or other faceted and more irregularly arranged shape.) Drawings of Peyer's patches appear after pages 22 and 24.</ref> They are an important part of gut associated lymphoid tissue usually found in humans in the lowest portion of the small intestine, mainly in the distal jejunum and the ileum, but also could be detected in the duodenum.<ref name="Cornes J S 1965">Template:Cite journal</ref>

History

Peyer's patches had been observed and described by several anatomists during the 17th century,<ref>Template:Cite book Anatomists who mentioned Peyer's patches included:

• Johann Theodor Schenck (1619–1671): Template:Cite book Schenk thought that intestinal worms resided in Peyer's patches and that the orifices of the patches were the worms' mouths. From p. 334: "In canibus saepissime observavi non ad ventriculum … a praeter labente chylo sibi conveniens allicerent." (In dogs, I very often noticed — not only near the stomach but also on the walls of their small intestines — flesh-colored or glandular blisters, [appearing] to swim one after another, [in] which, when we dissected [them], I observed some smooth reddish worms [vermium] living there in clusters [with] their heads facing towards the cavity of the intestines, in which part there were glands with orifices, [but] reversed, so that from there they obtained, from the chyle flowing past, nourishment [that was] suitable for them.)
• Jeremias Loss (1643–1684): Template:Cite book On page 12, Loss states that some glands are located "inter Membranas viscerum quorundam" (between the membranes of certain internal organs) " … prout id in Glandulis Intestinorum satis manifestum est." (as it is quite clear in the glands of the intestines), where "In Intestinis ita congregantur, interdum pauciores, interdum plures, ut areolas quasdam constituant: … " (in the intestines there are thus gathered sometimes fewer [glands], sometimes more [glands], so that they form certain round patches.)
• Johannes Nicolaus Pechlin (1646–1706): Template:Cite book From p. 510: " … ego tenuium glandularum glomeratum agmen esse ratus, … " (… I considered the heaped cluster of fine glands, … )
• Martin Lister (ca. 1638–1712): Template:Cite journal From p. 6062: "As 1. Glandulae miliares of the small Guts, which may also in some Animals be well call'd fragi-formes, from the figure of the one half of a Strawberry, and which yet I take to be Excretive glanduls, because Conglomerate."
• Nehemiah Grew (1641–1712): Template:Cite book Grew called Peyer's patches pancreas intestinale.</ref> but in 1677 Swiss anatomist Johann Conrad Peyer (1653–1712) described the patches so clearly that they were eventually named after him.<ref name = "Peyer" /><ref>There were many earlier names for Peyer's patches:
• Template:Cite book
• Template:Cite book</ref> However, Peyer believed they were glands that secreted something into the small intestine to facilitate digestion. It was not until 1850 that the Swiss physician Rudolph Oskar Ziegler (1828–1881) suggested, after careful microscopic examination, that Peyer's patches were actually lymph glands.<ref>Ziegler, Rudolph Oskar (1850) Ueber die solitären und Peyerschen Follikel : Inaugural-Abhandlung, der medicinischen Facultät der Julius-Maximilians-Universität zu Würzburg vorgelegt [On solitary and Peyer's follicles: Inaugural treatise, submitted to the medical faculty of the Julius-Maximilians-University of Würzburg] (in German) Würzburg, (Germany): Friederich Ernst Thein. From p. 37: "Ebensogross, wo nicht grösser ist die Aehnlichkeit der sogenannten Peyer'schen Drüsen und der Lymphdrüsen." (Just as great, if not greater, is the resemblance between the so-called Peyer's glands and the lymph glands.) From p. 38: " … ja, man könnte selbst versucht sein, die letzteren für nichts als eine Art von zwischen den Wänden der Darmsschleimhaut eingebetteten Lymphdrüsen zu halten." ( … indeed, one could even be tempted to regard the latter [i.e., the Peyer's patches] as nothing but some type of lymph glands [which are] embedded between the walls of the intestinal mucosa.)</ref>

Structure

Peyer's patches are observable as elongated thickenings of the intestinal mucosa measuring a few centimeters in length. About 100 are found in humans. Microscopically, Peyer's patches appear as oval or round lymphoid follicles (similar to lymph nodes) located in the mucosa layer of the ileum and extend into the submucosa layer. The number of Peyer's patches peaks at age 15–25 and then declines during adulthood.<ref name="Cornes J S 1965"/> In the distal ileum, they are numerous and they form a lymphoid ring. At least 46% of Peyer's patches are concentrated in the distal 25 cm of ileum in humans. It is important to note that there are large variations in size, shape, and distribution of Peyer's patches from one individual to another one.<ref>Template:Cite journal</ref> In adults, B lymphocytes are seen to dominate the follicles' germinal centers. T lymphocytes are found in the zones between follicles. Among the mononuclear cells, CD4+/CD25+ (10%) cells and CD8+/CD25+ (5%) cells are more abundant in Peyer's patches than in the peripheral blood.<ref name="pmid21188221">Template:Cite journal</ref>

Peyer's patches are characterized by the follicle-associated epithelium (FAE), which covers all lymphoid follicles.<ref name="ReferenceA">Template:Cite journal</ref> FAE differs from typical small intestinal villus epithelium: it has fewer goblet cells<ref>Template:Cite journal</ref> therefore mucus layer is thinner,<ref>Template:Cite journal</ref> and it is also characterized by the presence of specialized M cells or microfold cells, which provide uptake and transport of antigens from lumen.<ref name="ReferenceA"/> Moreover, basal lamina of follicle-associated epithelium is more porous compared to intestinal villus.<ref>Template:Cite journal</ref> Finally, follicle-associated epithelium is less permeable for ions and macromolecules, basically due to higher expression of tight junction proteins.<ref>Template:Cite journal</ref>

Function

Because the lumen of the gastrointestinal tract is exposed to the external environment, much of it is populated with potentially pathogenic microorganisms. Peyer's patches thus establish their importance in the immune surveillance of the intestinal lumen and in facilitating production of the immune response within the mucosa.

Pathogenic microorganisms and other antigens entering the intestinal tract encounter macrophages, dendritic cells, B-lymphocytes, and T-lymphocytes found in Peyer's patches and other sites of gut-associated lymphoid tissue (GALT). Peyer's patches thus act for the gastrointestinal system much as the tonsils act for the respiratory system, trapping foreign particles, surveilling them, and destroying them. Peyer's patches have adaptive immune capabilities through inducing selective apoptosis of B cells due CD122-targeted interleukin-2 (IL-2) signaling. Additionally, the B cell population can be restored. <ref>Template:Cite journal</ref>

Peyer's patches are covered by a special follicle-associated epithelium that contains specialized cells called microfold cells (M cells) which sample antigen directly from the lumen and deliver it to antigen-presenting cells (located in a unique pocket-like structure on their basolateral side). Dendritic cells and macrophages can also directly sample the lumen by extending dendrites through transcellular M cell-specific pores.<ref>Template:Cite journal</ref><ref>Template:Cite journal</ref> At the same time the paracellular pathway of follicle-associated epithelium is closed tightly to prevent penetration of antigens and continuous contact with immune cells.<ref>Template:Cite journal</ref> T cells, B-cells and memory cells are stimulated upon encountering antigen in Peyer's patches. These cells then pass to the mesenteric lymph nodes where the immune response is amplified. Activated lymphocytes pass into the blood stream via the thoracic duct and travel to the gut where they carry out their final effector functions. The maturation of B-lymphocytes takes place in the Peyer's patch.

Clinical significance

Although important in the immune response, excessive growth of lymphoid tissue in Peyer's patches is pathologic, as hypertrophy of Peyer's patches has been closely associated with idiopathic intussusception.

Having too many or larger than normal Peyer's patches is associated with an increased risk of prion diseases, and intussusception in children. A history of viral illness is a risk factor for enlarged or inflamed Peyer's patches.<ref>Template:Cite book</ref>

Salmonella typhi and poliovirus also target this section of the intestine.<ref name=BMJ />

Disturbances in the gut microbiota and immune regulation within Peyer's patches are implicated in the pathogenesis of autoimmune diseases, such as Crohn's disease, where chronic inflammation can arise due to overactive immune responses.<ref name=C/> As Peyer's patches are packed with immune cells and produce protective proteins such as secretory IgA to maintain gut balance, their dysfunction can trigger inappropriate immune responses, driving the inflammation and tissue damage characteristic of autoimmune diseases.<ref>Template:Cite journal</ref>

See also

• Influenza
• Lung cancer