Lymphedema

Lymphedema, also known as lymphoedema and lymphatic edema, is a condition of localized swelling caused by a compromised lymphatic system.<ref name="Lymphedema Diagnostic workup" /> The lymphatic system functions as a critical portion of the body's immune system and returns interstitial fluid to the bloodstream.

Lymphedema is most frequently a complication of cancer treatment or parasitic infections, but it can also be seen in a number of genetic disorders. Tissues with lymphedema are at high risk of infection because the lymphatic system has been compromised.<ref>Template:Cite book</ref>

Though incurable and progressive, a number of treatments may improve symptoms.<ref name="Lymphedema Diagnostic workup" /> This commonly includes compression therapy, good skin care, exercise, and manual lymphatic drainage (MLD), which together are known as combined decongestive therapy.<ref name="Lymphedema Diagnostic workup" /> Diuretics are not useful.<ref name="Lymphedema Diagnostic workup" /> Template:TOC limit

Signs and symptoms

File:Dr. Ming-Huei Cheng's lymphedema Sample.png

Lymphedema seen on CT scan

The most common manifestation of lymphedema is soft tissue swelling (edema). As the disorder progresses, worsening edema and skin changes including discoloration, verrucous (wart-like) hyperplasia, hyperkeratosis, papillomatosis, dermal thickening, and ulcers may be seen. Additionally, there is increased risk of infection of the skin, known as erysipelas.Template:Citation needed

Complications

When lymphatic impairment becomes so great that the collected lymph fluid exceeds the lymphatic system's ability to transport it, an abnormal amount of protein-rich fluid collects in the tissues. Left untreated, this stagnant, protein-rich fluid causes tissue channels to increase in size and number, reducing oxygen availability. This interferes with wound healing and provides a rich medium for bacterial growth which can result in skin infections, lymphangitis, lymphadenitis, and, in severe cases, skin ulcers.<ref name="grada-2017" /> It is vital for lymphedema patients to be aware of the symptoms of infection and to seek immediate treatment, since recurrent infections or cellulitis, in addition to their inherent danger, further damage the lymphatic system and set up a vicious circle.Template:Citation needed

In rare cases, lymphedema may lead to a form of cancer called lymphangiosarcoma, although the mechanism of carcinogenesis is not understood. Lymphedema-associated lymphangiosarcoma is called Stewart–Treves syndrome.<ref name="grada-2017" /> Lymphangiosarcoma most frequently occurs in cases of long-standing lymphedema. The incidence of angiosarcoma five years after radical mastectomy is estimated to be 0.45% in surviving patients.<ref>Template:Cite journal</ref><ref>Template:Cite journal</ref> Lymphedema is also associated with a low grade form of cancer called retiform hemangioendothelioma (a low grade angiosarcoma).<ref>Template:Cite journal</ref>

Lymphedema can be disfiguring, and may result in a poor body image and psychological distress.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> Complications of lymphedema can cause difficulties in activities of daily living.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

Causes and risk factors

Lymphedema may be inherited (primary) or caused by injury to the lymphatic vessels (secondary).<ref name="Visual Guide to Lymphedema">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> There are also risk factors that may increase one's risk of developing lymphedema such as old age, being overweight or obese, and having rheumatic or psoriatic arthritis.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

Lymph node damage

Lymphedema is most commonly seen after lymph node dissection, surgery or radiation therapy for the treatment of cancer, most notably breast cancer. In many patients the condition does not develop until months or even years after therapy has concluded.Template:Medical citation needed Lymphedema may also be associated with accidents or certain diseases or conditions that may inhibit the lymphatic system from functioning properly.<ref name="grada-2017" /> It can also be caused by damage to the lymphatic system from infections such as cellulitis.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> In tropical areas of the world where parasitic filarial worms are endemic, a common cause of secondary lymphedema is filariasis.<ref>Template:Cite journal</ref>

Primary lymphedema may be congenital or may arise sporadically. Multiple syndromes are associated with primary lymphedema, including Turner syndrome, Milroy's disease, and Klippel–Trénaunay syndrome. In these syndromes it may occur as a result of absent or malformed lymph nodes or lymphatic channels. Lymphedema can be present at birth, develop at the onset of puberty (praecox), or not become apparent for many years into adulthood (tarda). In men, lower-limb primary lymphedema is most common, occurring in one or both legs. Some cases of lymphedema may be associated with other vascular abnormalities.<ref name="grada-2017" />Template:Citation needed

Secondary lymphedema affects both men and women, and, in Western countries, is most commonly due to cancer treatment.<ref name="Brorson2008">Template:Cite journal</ref> In women, it is most prevalent in an upper limb after breast cancer surgery, especially axillary lymph node dissection,<ref>Template:Cite book</ref> and occurs on the same side of the body as the surgery. Breast and trunk lymphedema can also occur but go unrecognised as there is swelling in the area after surgery, and its symptoms (peau d'orange and an inverted nipple) can be confused with post surgery fat necrosis.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> Between 38 and 89% of breast cancer patients have lymphedema due to axillary lymph node dissection or radiation.<ref name="Brorson2008" /><ref>Template:Cite journal</ref><ref>Template:Cite journal</ref> Unilateral lymphedema of a lower limb occurs in up to 41% of patients after gynecologic cancer.<ref name="Brorson2008" /><ref>Template:Cite journal</ref> For men treated for prostate cancer, a 5-66% incidence has been reported, with the incidence rate depending on whether staging or radical removal of lymph glands was done in addition to radiotherapy.<ref name="Brorson2008" /><ref>Template:Cite journal</ref><ref>Template:Cite journal</ref>

Head and neck lymphedema can be caused by surgery or radiation therapy for tongue or throat cancer. It may also occur in the lower limbs or groin after surgery for colon, ovarian or uterine cancer, if removal of lymph nodes or radiation therapy is required. Surgery or treatment for prostate, colon and testicular cancers may result in secondary lymphedema, particularly when lymph nodes have been removed or damaged.Template:Medical citation needed

The onset of secondary lymphedema in patients who have had cancer surgery has also been linked to aircraft flight (likely due to decreased cabin pressure or relative immobility). For cancer survivors wearing a prescribed and properly fitted compression garment may help decrease swelling during air travel.<ref>Template:Cite journal</ref>

Some cases of lower-limb lymphedema have been associated with the use of tamoxifen, due to blood clots and deep vein thrombosis (DVT) associated with this medication. Resolution of the blood clots or DVT is needed before lymphedema treatment can be initiated.Template:Medical citation needed

At birth

Hereditary lymphedema is a primary lymphedema – swelling that results from abnormalities in the lymphatic system that are present from birth. Swelling may be present in a single limb, several limbs, genitalia, or the face. It is sometimes diagnosed prenatally by a nuchal scan or postnatally by lymphoscintigraphy.Template:Medical citation needed

The most common cause is Meige disease which usually presents at puberty. Another form of hereditary lymphedema is Milroy's disease, caused by mutations in the VEGFR3 gene.<ref name="grada-2017" /><ref>Template:Cite bookTemplate:Dead link</ref> Hereditary lymphedema is frequently syndromic and is associated with Turner syndrome, lymphedema–distichiasis syndrome, yellow nail syndrome, and Klippel–Trénaunay syndrome.<ref>Template:Cite bookTemplate:Dead link</ref>

One defined genetic cause for hereditary lymphedema is GATA2 deficiency. This deficiency is a grouping of several disorders caused by a single defect: familial or sporadic inactivating mutations in one of the two parental GATA2 genes. These autosomal dominant mutations cause a reduction, i.e. a haploinsufficiency, in the cellular levels of the gene's product, GATA2. The GATA2 protein is a transcription factor critical for the development, maintenance, and functionality of blood-forming, lymphatic-forming, and other tissue-forming stem cells. Due to these mutations cellular levels of GATA2 are deficient and over time individuals develop hematological, immunological, lymphatic, and other disorders. GATA2 deficiency-induced defects in the lymphatic vessels and valves underlies the development of lymphedema, primarily in the lower extremities but may also occur in places such as the face or testes. This form of the deficiency, when coupled with sensorineural hearing loss, which may also be due to faulty development of the lymphatic system, is sometimes termed Emberger syndrome.<ref>Template:Cite journal</ref><ref>Template:Cite journal</ref>

Primary lymphedema occurs in approximately one to three births out of every 10,000 births, with a female to male ratio of 3.5:1. In North America, the incidence of primary lymphedema is approximately 1.15 births out of every 100,000 births.Template:Contradictory inline Compared to secondary lymphedema, primary lymphedema is relatively rare.<ref>Template:Cite journal</ref>

Inflammatory lymphedema

{{#invoke:Labelled list hatnote|labelledList|Main article|Main articles|Main page|Main pages}} Bilateral lower extremity inflammatory lymphedema (BLEIL) is a distinct type of lymphedema occurring in a setting of acute and prolonged standing, such as in new recruits during basic training.<ref>Template:Cite journal</ref> Possible underlying mechanisms may include venous congestion and inflammatory vasculitis.<ref>Template:Cite journal</ref>

Physiology

Lymph is formed from the fluid that filters out of blood and contains proteins, cellular debris, bacteria, etc. This fluid is collected by the initial lymph collectors that are blind-ended endothelial-lined vessels with fenestrated openings that allow fluids and particles as large as cells to enter. Once inside the lumen of the lymphatic vessels, the fluid is guided along increasingly larger vessels, first with rudimentary valves to prevent backflow, later with complete valves similar to the venous valve. Once the lymph enters the fully valved lymphatic vessels, it is pumped by a rhythmic peristaltic-like action by smooth muscle cells within the lymphatic vessel walls. This peristaltic action is the primary driving force moving lymph within its vessel walls. The sympathetic nervous system regulates the frequency and power of the contractions. Lymph movement can be influenced by the pressure of nearby muscle contraction, arterial pulse pressure and the vacuum created in the chest cavity during respiration, but these passive forces contribute only a minor percentage of lymph transport. The fluids collected are pumped into continually larger vessels and through lymph nodes, which remove debris and police the fluid for dangerous microbes. The lymph ends its journey in the thoracic duct or right lymphatic duct, which drain into the blood circulation.<ref name="Visual Guide to Lymphedema" />

Several research groups have hypothesized that chronic inflammation is a key regulator in the development of lymphedema. Th cells, particularly Th2 differentiation, play a crucial role in the pathophysiology of lymphedema. Research has shown that increased expression of Th2-inducing cytokines in the epidermal cells of the lymphoedematous limb. Treatment with QBX258 has been found to decrease hyperkeratosis and fibrosis, reduce the number of CD4+ cells, and normalize the expression of Th2-inducing cytokines and IL13R by keratinocytes. These findings suggest that epidermal cells may initiate or coordinate chronic Th2 responses in lymphedema.<ref name=":1">Template:Cite journal</ref>

Role of T-Cell inflammation and Th2 response

Lymphedema involves a complex interplay of inflammatory processes. Recent research has shed light on the role of T-cell inflammation and the Th2 immune response in the initiation of lymphedema.<ref name=":0">Template:Cite journal</ref>

T-Cell inflammation and fibrosis

Studies have revealed that sustained lymphatic stasis results in the infiltration of CD4+ T-cells, leading to inflammation and fibrosis within affected tissues.<ref name=":0" />

Diagnosis

Diagnosis is generally based on signs and symptoms, with testing used to rule out other potential causes.<ref name="Lymphedema Diagnostic workup" /> An accurate diagnosis and staging may help with management.<ref name="Lymphedema Diagnostic workup">Template:Cite journal</ref> A swollen limb can result from different conditions that require different treatments. Diagnosis of lymphedema is currently based on history, physical exam, and limb measurements. Imaging studies such as lymphoscintigraphy and indocyanine green lymphography are only required when surgery is being considered.<ref name="Lymphedema Diagnostic workup" /> However, the ideal method of staging to guide treatment is controversial because of several different proposed protocols.<ref>Template:Cite journal</ref><ref>Template:Cite journal</ref>

Lymphedema can occur in both the upper and lower extremities, and in some cases, the head and neck. Assessment of the extremities first begins with a visual inspection; color, presence of hair, visible veins, size and any sores or ulcerations are noted. Lack of hair may indicate an arterial circulation problem.<ref name="Jarvis2004">Template:Cite book</ref> In cases of swelling, the extremities' circumference is measured over time for reference. In early stages of lymphedema, elevating the limb may reduce or eliminate the swelling. Palpation of the wrist or ankle can determine the degree of swelling; assessment includes a check of the pulses. The axillary or inguinal lymph nodes may be enlarged due to the swelling. Enlargement of the nodes lasting more than three weeks may indicate infection or other illnesses (such as sequela from breast cancer surgery) requiring further medical attention.<ref name="Jarvis2004" />

Diagnosis or early detection of lymphedema is difficult. The first signs may be subjective observations such as a feeling of heaviness in the affected extremity. These may be symptomatic of early-stage lymphedema where accumulation of lymph is mild and not detectable by changes in volume or circumference. As lymphedema progresses, definitive diagnosis is commonly based upon an objective measurement of differences between the affected or at-risk limb and the opposite unaffected limb, e.g. in volume or circumference. No generally accepted criterion is definitively diagnostic, although a volume difference of 200 ml between limbs or a Template:Convert difference (at a single measurement site or set intervals along the limb) is often used. Bioimpedance measurement (which measures the amount of fluid in a limb) offers greater sensitivity than other methods.<ref>Template:Cite journal</ref> Devices like SOZO <ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> utilize Bioimpedence Analysis (BIA) by sending a current through the body and measuring the resultant impedance. Another approach involves Tissue Dielectric Constant (TDC) measurement, used by devices such as Delfin Technology's MoistureMeterD and LymphScanner,<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> which employ microwaves to detect changes in the dielectric properties of tissue. These innovative techniques have become integral to official protocols for lymphedema detection.<ref>Template:Cite journal</ref>

Chronic venous stasis changes can mimic early lymphedema, but are more often bilateral and symmetric. Lipedema can also mimic lymphedema, however lipedema characteristically spares the feet beginning abruptly at the malleolus (ankle).<ref name="Lymphedema Diagnostic workup" /> As a part of the initial work-up before diagnosing lymphedema, it may be necessary to exclude other potential causes of lower extremity swelling such as kidney failure, hypoalbuminemia, congestive heart-failure, protein-losing kidney disease, pulmonary hypertension, obesity, pregnancy and drug-induced edema.Template:Citation needed

Classification

File:Cheng's Lymphedema Grading.png

Cheng's Lymphedema Grading

The International Society of Lymphology (ISL) Staging System is based solely on subjective symptoms, making it prone to substantial observer bias. Imaging modalities have been suggested as useful adjuncts to the ISL staging to clarify the diagnosis, such as Cheng's Lymphedema Grading tool, which assesses the severity of extremity lymphedema based on objective limb measurements and provides appropriate options for management.<ref>Template:Cite journal</ref><ref>Template:Cite journal</ref><ref>Template:Cite book</ref>

I. Grading

• Grade 1: Spontaneously reversible on elevation. Mostly pitting edema.
• Grade 2: Non-spontaneously reversible on elevation. Mostly non-pitting edema.
• Grade 3: Gross increase in volume and circumference of Grade 2 lymphedema, with eight stages of severity given below based on clinical assessments.

II. Staging

As described by the Fifth WHO Expert Committee on Filariasis,<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref><ref>Template:Cite journal</ref> and endorsed by the American Society of Lymphology,<ref>Template:Cite bookTemplate:Page needed</ref>Template:Citation needed the staging system helps to identify the severity of lymphedema. With the assistance of medical imaging, such as MRI or CT, staging can be established by the physician, and therapeutic or medical interventions may be applied:Template:Citation needed

• Stage 0: The lymphatic vessels have sustained some damage that is not yet apparent. Transport capacity is sufficient for the amount of lymph being removed. Lymphedema is not present.
• Stage 1 : Swelling increases during the day and disappears overnight as the patient lies flat in bed. Tissue is still at the pitting stage: when pressed by the fingertips, the affected area indents and reverses with elevation. Usually, upon waking in the morning, the limb or affected area is normal or almost normal in size. Treatment is not necessarily required at this point.
• Stage 2: Swelling is not reversible overnight, and does not disappear without proper management. The tissue now has a spongy consistency and is considered non-pitting: when pressed by the fingertips, the affected area bounces back without indentation. Fibrosis found in Stage 2 lymphedema marks the beginning of the hardening of the limbs and increasing size.
• Stage 3: Swelling is irreversible and usually the limb(s) or affected area becomes increasingly large. The tissue is hard (fibrotic) and unresponsive; some patients consider undergoing reconstructive surgery, called "debulking". This remains controversial, however, since the risks may outweigh the benefits and further damage done to the lymphatic system may make the lymphedema worse.
• Stage 4: The size and circumference of the affected limb(s) become noticeably larger. Bumps, lumps, or protrusions (also called knobs) on the skin begin to appear.
• Stage 5: The affected limb(s) become grossly large; one or more deep skin folds is present.
• Stage 6: Knobs of small elongated or rounded sizes cluster together, giving mossy-like shapes on the limb. Mobility of the patient becomes increasingly impaired.
• Stage 7: The person becomes "handicapped", and is unable to independently perform daily routine activities such as walking, bathing and cooking. Assistance from the family and health care system is needed.

Grades

Lymphedema can also be categorized by its severity (usually compared to a healthy extremity):<ref>Template:Cite journal</ref>

• Grade 1 (mild edema): Involves the distal parts such as a forearm and hand or a lower leg and foot. The difference in circumference is less than Template:Convert and no other tissue changes are present.
• Grade 2 (moderate edema): Involves an entire limb or corresponding quadrant of the trunk. Difference in circumference is Template:Convert. Tissue changes, such as pitting, are apparent. The patient may experience erysipelas.
• Grade 3a (severe edema): Lymphedema is present in one limb and its associated trunk quadrant. Circumferential difference is greater than Template:Convert. Significant skin alterations, such as cornification, keratosis, cysts or fistulae, are present. Additionally, the patient may experience repeated attacks of erysipelas.
• Grade 3b (massive edema): The same symptoms as grade 3a, except that two or more extremities are affected.
• Grade 4 (gigantic edema): In this stage of lymphedema, the affected extremities are huge, due to almost complete blockage of the lymph channels.

Differential

Lymphedema should not be confused with edema arising from chronic venous insufficiency, which is caused by compromise of venous drainage rather than lymphatic drainage. However, untreated venous insufficiency can progress into a combined venous/lymphatic disorder known as phlebetic lymphedema (or phlebolymphedema).<ref>Template:Cite journal</ref><ref>Template:Cite journal</ref><ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

Treatment

While there is no cure, treatment may improve outcomes.<ref name="Lymphedema Diagnostic workup" /> This commonly include compression therapy, good skin care, exercise, manual lymphatic drainage (MLD) and the use of an intermittent pneumatic compression pump, which together is known as combined decongestive therapy.<ref name="Lymphedema Diagnostic workup" /> MLD is most effective in mild to moderate disease.<ref name="Ezzo2015">Template:Cite journal</ref> In breast cancer-related lymphedema, MLD is safe and may offer added benefit to compression bandages for reducing swelling.<ref name="Ezzo2015" /> Most people with lymphedema can be medically managed with conservative treatment.<ref>Template:Cite journal</ref> Diuretics are not useful.<ref name="Lymphedema Diagnostic workup" /> Surgery is generally only used if symptoms are not improved by other measures.<ref name="Lymphedema Diagnostic workup" /><ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

Compression

Garments

File:Lymphedema Compression sleeve November 2106 Second Skin 016.jpg

Lymphedema compression sleeve on a mannequin

Once a person is diagnosed with lymphedema, compression becomes imperative in the management of the condition. Garments are often intended to be worn all day but may be taken off for sleep, unless otherwise prescribed. Elastic compression garments are worn on the affected limb following complete de-congestive therapy to maintain edema reduction. Inelastic garments provide containment and reduction.<ref name="Lymphedema Diagnostic workup" /> Available styles, options, and prices vary widely. A professional garment fitter or certified lymphedema therapist can help determine the best option for the patient.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

Bandaging

Compression bandaging, also called wrapping, is the application of layers of padding and short-stretch bandages to the involved areas. Short-stretch bandages are preferred over long-stretch bandages (such as those normally used to treat sprains), as the long-stretch bandages cannot produce the proper therapeutic tension necessary to safely reduce lymphedema and may produce a tourniquet effect. Compression bandages provide resistance that assists in pumping fluid out of the affected area during exercise. This counter-force results in increased lymphatic drainage and therefore a decrease in size of the swollen area.<ref name="tan-2019">Template:Cite journal</ref>

Intermittent pneumatic compression therapy

Intermittent pneumatic compression therapy (IPC) utilizes a multi-chambered pneumatic sleeve with overlapping cells to promote movement of lymph fluid.<ref name="Lymphedema Diagnostic workup" /> Pump therapy should only be used in addition to other treatments such as compression bandaging and manual lymph drainage. Pump therapy has been used in the past to help with controlling lymphedema. In some cases, pump therapy helps soften fibrotic tissue and therefore potentially enable more efficient lymphatic drainage.<ref>Template:Cite journal</ref> However, reports link pump therapy to increased incidence of edema proximal to the affected limb, such as genital edema arising after pump therapy in the lower limb.<ref>Template:Cite journal</ref> Current literature has suggested the use of IPC treatment in conjunction with an elastic therapeutic tape is more effective in the overall reduction of lymphedema as well as increasing shoulder range of motion than the traditional treatment of IPC paired with complete decongestive therapy. The tape is an elastic cotton strip with an acrylic adhesive that is used commonly used to relieve the discomfort and disability associated with sports injuries, but in the context of lymphedema, this increases the space between the dermis and the muscle which increases the opportunity for lymphatic fluid to flow out naturally.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref><ref name="Effects of Kinesio Taping">Template:Cite journal</ref> The use of IPC treatments with tape, as well as subsequent lymphatic drainage, has proven to significantly reduce the circumference of lymphatic limbs in patients experiencing lymphedema secondary to breast cancer post-mastectomy.<ref name="Effects of Kinesio Taping" />

Exercise

In those with lymphedema or at risk of developing lymphedema, such as following breast cancer treatment, resistance training did not increase swelling and led to decreases in some, in addition to other potential beneficial effects on cardiovascular health.<ref>Template:Cite journal</ref><ref>Template:Cite journal</ref> Moreover, resistance training and other forms of exercise were not associated with an increased risk of developing lymphedema in people who previously received breast cancer-related treatment. Compression garments should be worn during exercise.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

Physical therapy for patients with lymphedema may include trigger point release, soft tissue massage, postural improvement, patient education on condition management, strengthening, and stretching exercises. Exercises may increase in intensity and difficulty over time, beginning with passive movements to increase range of motion and progressing towards using external weights and resistance in various postures.<ref name="tan-2019" />

Surgery

The treatment of lymphedema is usually conservative, however the use of surgery is proposed for some cases.<ref>Template:Cite journal</ref>

Suction assisted lipectomy (SAL), also known as liposuction for lymphedema, may help improve chronic non pitting edema.<ref name="Granzow2013" /> The procedure removes fat and protein and is done alongside continued compression therapy.<ref name="Granzow2013">Template:Cite journal</ref>

Vascularized lymph node transfers (VLNT) and lymphovenous bypass are supported by tentative evidence Template:As of but are associated with a number of complications.<ref name="Lymphedema Diagnostic workup" />Template:Example needed

Laser therapy

Low-level laser therapy (LLLT) was cleared by the US Food and Drug Administration (FDA) for the treatment of lymphedema in November 2006.<ref>dotmed.com December 27, 2006 Template:Webarchive Low Level Laser FDA Cleared for the Treatment of Lymphedema. (accessed 9 November 09)</ref> According to the US National Cancer Institute, LLLT may be effective in reducing lymphedema in some women. Two cycles of laser treatment were found to reduce the volume of the affected arm in approximately one-third of people with post-mastectomy lymphedema at three months post-treatment.<ref>National Cancer Institute: Low-level laser therapy Template:Webarchive accessed 9 November 09</ref><ref>Template:Cite journal</ref>

A new therapeutic approach involving the drug QBX258 has shown promising results in the treatment of lymphedema. Although it did not reach statistical significance, QBX258 treatment modestly decreased periostin expression and the number of CD4+ and CD4+IL4+ cells in lymphoedematous skin. Notably, QBX258 significantly reduced the expression of Th2-inducing cytokines, improving physical and social quality-of-life measures for patients. However, psychological improvements were not observed.<ref name=":1" />

Epidemiology

Lymphedema affects approximately 200 million people worldwide.<ref name="grada-2017">Template:Cite journal</ref>