LCN can refer to:
- La Coka Nostra, a hiphop music group
- La Cosa Nostra ("this thing of ours"): Italian or Italian-émigré organized crime syndicates, including:
- Landing Craft Navigation, a type of watercraft used in World War 2 for surveying landing sites for troops from landing craft
- Law Centres Network, the peak body for law centres in the UK
- Le Canal Nouvelles, a television channel in Quebec, Canada
- Lincoln railway station, whose station code is LCN
- Load Classification Number, also known as the Pavement Classification Number, a measure of the bearing strength of an airport runway
- Logical channel number (aka virtual channel), channel numbers used on radio and television sets
- Logical cluster number of a volume or logical drive of a computer
- London Centre for Nanotechnology, a nanotechnology research institute in London, England
- Low copy number, a DNA profiling technique
- Lcn. (× Laeliocatanthe), a hybrid genus of orchids, corresponding to Cattleya × Laelia × Guarianthe
- Balcanoona Airport, IATA airport code "LCN"