Linus Pauling

Template:Short description Template:Use mdy dates Template:Use American English Template:Infobox scientist

Linus Carl Pauling Template:Post-nominals (Template:IPAc-en Template:Respell; February 28, 1901Template:SndAugust 19, 1994)<ref name="ChemNobel">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> was an American chemist, biochemist, chemical engineer, peace activist, author, and educator. He published more than 1,200 papers and books, of which about 850 dealt with scientific topics.<ref name="VolumeI">Template:Cite book</ref> New Scientist called him one of the 20 greatest scientists of all time.<ref name="Horgan">Template:Cite magazine</ref> For his scientific work, Pauling was awarded the Nobel Prize in Chemistry in 1954. For his peace activism, he was awarded the Nobel Peace Prize in 1962. He is one of five people to have won more than one Nobel Prize (the others being Marie Curie, John Bardeen, Frederick Sanger, and Karl Barry Sharpless).<ref name="Nobel">Template:Nobelprize</ref> Of these, he is the only person to have been awarded two unshared Nobel Prizes,<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> and one of two people to be awarded Nobel Prizes in different fields, the other being Marie Curie.<ref name="Nobel" />

Pauling was one of the founders of the fields of quantum chemistry and molecular biology.<ref name="natureobit">Template:Cite journal</ref> His contributions to the theory of the chemical bond include the concept of orbital hybridisation and the first accurate scale of electronegativities of the elements. Pauling also worked on the structures of biological molecules, and showed the importance of the alpha helix and beta sheet in protein secondary structure. Pauling's approach combined methods and results from X-ray crystallography, molecular model building, and quantum chemistry. His discoveries inspired the work of Rosalind Franklin, James Watson, Francis Crick, and Maurice Wilkins on the structure of DNA, which in turn made it possible for geneticists to crack the DNA code of all organisms.<ref name="Contributions to DNA double-helix discovery">Template:Cite book</ref>

In his later years, he promoted nuclear disarmament, as well as orthomolecular medicine, megavitamin therapy,<ref name="isbn0-399-50764-7">Template:Cite book</ref> and dietary supplements, especially ascorbic acid (commonly known as Vitamin C). None of his ideas concerning the medical usefulness of large doses of vitamins have gained much acceptance in the mainstream scientific community.<ref name="Horgan" /><ref name="Offit">Template:Cite magazine</ref> He was married to the American human rights activist Ava Helen Pauling.

Early life and educationEdit

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Herman Henry William Pauling, Linus Pauling's father, Template:Circa

Linus Carl Pauling was born on February 28, 1901, in Portland, Oregon,<ref name="frs">Template:Cite journal</ref><ref name="childhood">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> the firstborn child of Herman Henry William Pauling (1876–1910) and Lucy Isabelle "Belle" Darling (1881–1926).<ref name="Nature">Template:Cite book</ref>Template:Rp He was named "Linus Carl", in honor of Lucy's father, Linus, and Herman's father, Carl.<ref name="MeadHager">Template:Cite book</ref>Template:Rp His ancestry included German and English.<ref name=":0">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref><ref>Template:Cite book</ref>

In 1902, after his sister Pauline was born, Pauling's parents decided to move out of Portland to find more affordable and spacious living quarters than their one-room apartment.<ref name="GoGo">Template:Cite book</ref>Template:Rp Lucy stayed with her husband's parents in Oswego until Herman brought the family to Salem, where he worked briefly as a traveling salesman for the Skidmore Drug Company. Within a year of Lucile's birth in 1904, Herman Pauling moved his family to Oswego, Oregon where he opened his own drugstore.Template:R He moved his family to Condon, Oregon, in 1905.Template:R By 1906, Herman Pauling was suffering from recurrent abdominal pain. He died of a perforated ulcer on June 11, 1910, leaving Lucy to care for Linus, Lucile and Pauline.Template:R

Pauling attributes his interest in becoming a chemist to being amazed by experiments conducted by a friend, Lloyd A. Jeffress, who had a small chemistry lab kit.Template:R He later wrote: "I was simply entranced by chemical phenomena, by the reactions in which substances, often with strikingly different properties, appear; and I hoped to learn more and more about this aspect of the world."<ref name="Abrams">Template:Cite book</ref>

In high school, Pauling conducted chemistry experiments by scavenging equipment and material from an abandoned steel plant. With an older friend, Lloyd Simon, Pauling set up Palmon Laboratories in Simon's basement. They approached local dairies offering to perform butterfat samplings at cheap prices but dairymen were wary of trusting two boys with the task, and the business ended in failure.Template:R

At age 15, the high school senior had enough credits to enter Oregon State University (OSU), known then as Oregon Agricultural College.Template:R Lacking two American history courses required for his high school diploma, Pauling asked the school principal if he could take the courses concurrently during the spring semester. Denied, he left Washington High School in June without a diploma.Template:R The school awarded him an honorary diploma 45 years later, after he was awarded two Nobel Prizes.<ref name="Nobel" /><ref>Template:Cite encyclopedia</ref><ref>Template:Cite news</ref>

Pauling held a number of jobs to earn money for his future college expenses, including working part-time at a grocery store for Template:Currency per week (equivalent to Template:Currency in Template:Inflation/year). His mother arranged an interview with the owner of a number of manufacturing plants in Portland, Mr. Schwietzerhoff, who hired him as an apprentice machinist at a salary of Template:Currency per month (equivalent to Template:Currency in Template:Inflation/year). This was soon raised to Template:Currency per month.Template:R Pauling also set up a photography laboratory with two friends.Template:R In September 1917, Pauling was finally admitted by Oregon State University. He immediately resigned from the machinist's job and informed his mother, who saw no point in a university education, of his plans.Template:R

Higher educationEdit

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Pauling's graduation photo from Oregon State University, 1922

In his first semester, Pauling registered for two courses in chemistry, two in mathematics, mechanical drawing, introduction to mining and use of explosives, modern English prose, gymnastics and military drill.Template:R His roommate was childhood pal and lifelong best friend Lloyd Jeffress.<ref name=Linus>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> He was active in campus life and founded the school's chapter of the Delta Upsilon fraternity.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> After his second year, he planned to take a job in Portland to help support his mother. The college offered him a position teaching quantitative analysis, a course he had just finished taking himself. He worked forty hours a week in the laboratory and classroom and earned Template:Currency a month (equivalent to Template:Currency in Template:Inflation/year), enabling him to continue his studies.Template:R

In his last two years at school, Pauling became aware of the work of Gilbert N. Lewis and Irving Langmuir on the electronic structure of atoms and their bonding to form molecules.Template:R He decided to focus his research on how the physical and chemical properties of substances are related to the structure of the atoms of which they are composed, becoming one of the founders of the new science of quantum chemistry.<ref name=":0" />

Engineering professor Samuel Graf (1887–1966)<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref><ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> selected Pauling to be his teaching assistant in a mechanics and materials course.Template:R<ref name="OSUArchives">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref><ref name="Marinacci">Template:Cite book</ref> During the winter of his senior year, Pauling taught a chemistry course for home economics majors. It was in one of these classes that Pauling met his future wife, Ava Helen Miller.Template:R Template:R<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref><ref name="AvaBook">Template:Cite news</ref>

In 1922, Pauling graduated with a degree in chemical engineering. He went on to graduate school at the California Institute of Technology (Caltech) in Pasadena, California, under the guidance of Roscoe Dickinson and Richard Tolman.<ref name="mathgene" /> His graduate research involved the use of X-ray diffraction to determine the structure of crystals. He published seven papers on the crystal structure of minerals while he was at Caltech. He received his PhD in physical chemistry and mathematical physics,<ref name="paulingphd" /> summa cum laude, in 1925.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

CareerEdit

Template:External mediaIn 1926, Pauling was awarded a Guggenheim Fellowship to travel to Europe, to study under German physicist Arnold Sommerfeld in Munich, Danish physicist Niels Bohr in Copenhagen and Austrian physicist Erwin Schrödinger in Zürich. All three were experts in the new field of quantum mechanics and other branches of physics.<ref name="Guggenheim" /> Pauling became interested in how quantum mechanics might be applied in his chosen field of interest, the electronic structure of atoms and molecules. In Zürich, Pauling was also exposed to one of the first quantum mechanical analyses of bonding in the hydrogen molecule, done by Walter Heitler and Fritz London.<ref name="Realism">Template:Cite conference</ref> Pauling devoted the two years of his European trip to this work and decided to make it the focus of his future research. He became one of the first scientists in the field of quantum chemistry and a pioneer in the application of quantum theory to the structure of molecules.<ref name="PNNL">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

In 1927, Pauling took a new position as an assistant professor at Caltech in theoretical chemistry.<ref name="OH">Template:Cite book</ref> He launched his faculty career with a very productive five years, continuing with his X-ray crystal studies and also performing quantum mechanical calculations on atoms and molecules. He published approximately fifty papers in those five years, and created the five rules now known as Pauling's rules.<ref>Template:Cite journal</ref><ref name="Pauling1960">Template:Cite book</ref> By 1929, he was promoted to associate professor, and by 1930, to full professor.<ref name="OH" /> In 1931, the American Chemical Society awarded Pauling the Langmuir Prize for the most significant work in pure science by a person 30 years of age or younger.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> The following year, Pauling published what he regarded as his most important paper, in which he first laid out the concept of hybridization of atomic orbitals and analyzed the tetravalency of the carbon atom.<ref>Template:Cite journal</ref>

At Caltech, Pauling struck up a close friendship with theoretical physicist Robert Oppenheimer at the University of California, Berkeley, who spent part of his research and teaching schedule as a visitor at Caltech each year.<ref name="Nature" /><ref name="Oppenheimer">Template:Cite book</ref> Pauling was also affiliated with Berkeley, serving as a visiting lecturer in physics and chemistry from 1929 to 1934.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> Oppenheimer even gave Pauling a stunning personal collection of minerals.<ref name="LostAlly">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> The two men planned to mount a joint attack on the nature of the chemical bond: apparently Oppenheimer would supply the mathematics and Pauling would interpret the results. Their relationship soured when Oppenheimer tried to pursue Pauling's wife, Ava Helen. When Pauling was at work, Oppenheimer came to their home and blurted out an invitation to Ava Helen to join him on a tryst in Mexico. She flatly refused, and reported the incident to Pauling. He immediately cut off his relationship with Oppenheimer.Template:R<ref name="Oppenheimer" />

In the summer of 1930, Pauling made another European trip, during which he learned about gas-phase electron diffraction from Herman Francis Mark. After returning, he built an electron diffraction instrument at Caltech with a student of his, Lawrence Olin Brockway, and used it to study the molecular structure of a large number of chemical substances.<ref name="Hargittai">Template:Cite book</ref>

Pauling introduced the concept of electronegativity in 1932.<ref name="paulingJACS">Template:Cite journal</ref> Using the various properties of molecules, such as the energy required to break bonds and the dipole moments of molecules, he established a scale and an associated numerical value for most of the elementsTemplate:Thinspthe Pauling Electronegativity Scale Template:Thinspwhich is useful in predicting the nature of bonds between atoms in molecules.<ref name="Scale2">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

In 1936, Pauling was promoted to chairman of the division of chemistry and chemical engineering at Caltech, and to the position of director of the Gates and Crellin Laboratories of Chemistry. He would hold both positions until 1958.<ref name="OH" /> Pauling also spent a year in 1948 at the University of Oxford as George Eastman Visiting Professor and Fellow of Balliol.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

Nature of the chemical bondEdit

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Linus Pauling with an inset of his Nobel Prize in 1955

In the late 1920s, Pauling began publishing papers on the nature of the chemical bond. Between 1937 and 1938, he took a position as George Fischer Baker Non-Resident Lecturer in Chemistry at Cornell University. While at Cornell, he delivered a series of nineteen lectures<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> and completed the bulk of his famous textbook The Nature of the Chemical Bond.<ref name="The George Fischer Baker Lectureship and the Beginnings of the Manuscript">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref><ref name="Pauling1960" />Template:Rp It is based primarily on his work in this area that he received the Nobel Prize in Chemistry in 1954 "for his research into the nature of the chemical bond and its application to the elucidation of the structure of complex substances".<ref name="Nobel" /> Pauling's book has been considered "chemistry's most influential book of this century and its effective bible".<ref name="Genes2001">Template:Cite book</ref> In the 30 years after its first edition was published in 1939, the book was cited more than 16,000 times. Even today, many modern scientific papers and articles in important journals cite this work, more than seventy years after the first publication.<ref name="Google">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

Part of Pauling's work on the nature of the chemical bond led to his introduction of the concept of orbital hybridization.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> While it is normal to think of the electrons in an atom as being described by orbitals of types such as s and p, it turns out that in describing the bonding in molecules, it is better to construct functions that partake of some of the properties of each. Thus the one 2s and three 2p orbitals in a carbon atom can be (mathematically) 'mixed' or combined to make four equivalent orbitals (called sp³ hybrid orbitals), which would be the appropriate orbitals to describe carbon compounds such as methane, or the 2s orbital may be combined with two of the 2p orbitals to make three equivalent orbitals (called sp² hybrid orbitals), with the remaining 2p orbital unhybridized, which would be the appropriate orbitals to describe certain unsaturated carbon compounds such as ethylene.Template:R Other hybridization schemes are also found in other types of molecules. Another area which he explored was the relationship between ionic bonding, where electrons are transferred between atoms, and covalent bonding, where electrons are shared between atoms on an equal basis. Pauling showed that these were merely extremes, and that for most actual cases of bonding, the quantum-mechanical wave function for a polar molecule AB is a combination of wave functions for covalent and ionic molecules.Template:R Here Pauling's electronegativity concept is particularly useful; the electronegativity difference between a pair of atoms will be the surest predictor of the degree of ionicity of the bond.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

The third of the topics that Pauling attacked under the overall heading of "the nature of the chemical bond" was the accounting of the structure of aromatic hydrocarbons, particularly the prototype, benzene.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> The best description of benzene had been made by the German chemist Friedrich Kekulé. He had treated it as a rapid interconversion between two structures, each with alternating single and double bonds, but with the double bonds of one structure in the locations where the single bonds were in the other. Pauling showed that a proper description based on quantum mechanics was an intermediate structure which was a blend of each. The structure was a superposition of structures rather than a rapid interconversion between them. The name "resonance" was later applied to this phenomenon.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> In a sense, this phenomenon resembles those of hybridization and also polar bonding, both described above, because all three phenomena involve combining more than one electronic structure to achieve an intermediate result.Template:Citation needed

Ionic crystal structuresEdit

In 1929, Pauling published five rules which help to predict and explain crystal structures of ionic compounds.<ref>Template:Cite journal</ref><ref name=Pauling1960/> These rules concern (1) the ratio of cation radius to anion radius, (2) the electrostatic bond strength, (3) the sharing of polyhedron corners, edges and faces, (4) crystals containing different cations, and (5) the rule of parsimony.Template:Citation needed

Biological moleculesEdit

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Pauling in 1941

File:Helix electron density myoglobin 2nrl 17-32.jpg

An alpha helix in ultra-high-resolution electron density contours, with O atoms in red, N atoms in blue, and hydrogen bonds as green dotted lines (PDB file 2NRL, 17–32)

In the mid-1930s, Pauling, strongly influenced by the biologically oriented funding priorities of the Rockefeller Foundation's Warren Weaver, decided to strike out into new areas of interest.<ref name="Kay">Template:Cite book</ref> Although Pauling's early interest had focused almost exclusively on inorganic molecular structures, he had occasionally thought about molecules of biological importance, in part because of Caltech's growing strength in biology. Pauling interacted with such great biologists as Thomas Hunt Morgan, Theodosius Dobzhanski, Calvin Bridges and Alfred Sturtevant.<ref name="Califano">Template:Cite book</ref> His early work in this area included studies of the structure of hemoglobin with his student Charles D. Coryell. He demonstrated that the hemoglobin molecule changes structure when it gains or loses an oxygen molecule.<ref name=Califano/> As a result of this observation, he decided to conduct a more thorough study of protein structure in general. He returned to his earlier use of X-ray diffraction analysis. But protein structures were far less amenable to this technique than the crystalline minerals of his former work. The best X-ray pictures of proteins in the 1930s had been made by the British crystallographer William Astbury, but when Pauling tried, in 1937, to account for Astbury's observations quantum mechanically, he could not.<ref name="Livio">Template:Cite book</ref>

It took eleven years for Pauling to explain the problem: his mathematical analysis was correct, but Astbury's pictures were taken in such a way that the protein molecules were tilted from their expected positions. Pauling had formulated a model for the structure of hemoglobin in which atoms were arranged in a helical pattern, and applied this idea to proteins in general.Template:Citation needed

In 1951, based on the structures of amino acids and peptides and the planar nature of the peptide bond, Pauling, Robert Corey and Herman Branson correctly proposed the alpha helix and beta sheet as the primary structural motifs in protein secondary structure.<ref>Template:Cite journal</ref><ref name="Goertzel and Goertzel, p. 95-100">Goertzel and Goertzel, p. 95-100.</ref> This work exemplified Pauling's ability to think unconventionally; central to the structure was the unorthodox assumption that one turn of the helix may well contain a non-integer number of amino acid residues; for the alpha helix it is 3.7 amino acid residues per turn.Template:Citation needed

Pauling then proposed that deoxyribonucleic acid (DNA) was a triple helix;<ref>Template:Cite journal</ref><ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> his model contained several basic mistakes, including a proposal of neutral phosphate groups, an idea that conflicted with the acidity of DNA. Sir Lawrence Bragg had been disappointed that Pauling had won the race to find the alpha helix structure of proteins. Bragg's team had made a fundamental error in making their models of protein by not recognizing the planar nature of the peptide bond. When it was learned at the Cavendish Laboratory that Pauling was working on molecular models of the structure of DNA, James Watson and Francis Crick were allowed to make a molecular model of DNA. They later benefited from unpublished data from Maurice Wilkins and Rosalind Franklin at King's College which showed evidence for a helix and planar base stacking along the helix axis. Early in 1953 Watson and Crick proposed a correct structure for the DNA double helix. Pauling later cited several reasons to explain how he had been misled about the structure of DNA, among them misleading density data and the lack of high quality X-ray diffraction photographs. Pauling described this situation as "the biggest disappointment in his life".<ref name="Dye-LATimes">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

During the time Pauling was researching the problem, Rosalind Franklin in England was creating the world's best images. They were key to Watson's and Crick's success. Pauling did not see them before devising his mistaken DNA structure, although his assistant Robert Corey did see at least some of them, while taking Pauling's place at a summer 1952 protein conference in England. Pauling had been prevented from attending because his passport was withheld by the State Department on suspicion that he had Communist sympathies. This led to the legend that Pauling missed the structure of DNA because of the politics of the day (this was at the start of the McCarthy period in the United States). Politics did not play a critical role. Not only did Corey see the images at the time, but Pauling himself regained his passport within a few weeks and toured English laboratories well before writing his DNA paper. He had ample opportunity to visit Franklin's lab and see her work, but chose not to.<ref name="Nature" />Template:Rp Despite these times, Pauling chose to move on from them and be thankful for the discoveries that he had already found.<ref name="Dye-LATimes"/>

Pauling also studied enzyme reactions and was among the first to point out that enzymes bring about reactions by stabilizing the transition state of the reaction, a view which is central to understanding their mechanism of action.<ref>Template:Cite book</ref> He was also among the first scientists to postulate that the binding of antibodies to antigens would be due to a complementarity between their structures.<ref name="Lewis">Template:Cite book</ref> Along the same lines, with the physicist turned biologist Max Delbrück, he wrote an early paper arguing that DNA replication was likely to be due to complementarity, rather than similarity, as suggested by a few researchers. This was made clear in the model of the structure of DNA that Watson and Crick discovered.<ref name="Tudge">Template:Cite book</ref>

Molecular geneticsEdit

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Pauling in 1948

In November 1949, Pauling, Harvey Itano, S. J. Singer and Ibert Wells published "Sickle Cell Anemia, a Molecular Disease"<ref name="Itano">Template:Cite journal Template:Dead link</ref> in the journal Science. It was the first proof of a human disease being caused by an abnormal protein, and sickle cell anemia became the first disease understood at the molecular level. (It was not, however, the first demonstration that variant forms of hemoglobin could be distinguished by electrophoresis, which had been shown several years earlier by Maud Menten and collaborators).<ref>Template:Cite journal</ref> Using electrophoresis, they demonstrated that individuals with sickle cell disease have a modified form of hemoglobin in their red blood cells, and that individuals with sickle cell trait have both the normal and abnormal forms of hemoglobin. This was the first demonstration causally linking an abnormal protein to a disease, and also the first demonstration that Mendelian inheritance determines the specific physical properties of proteins, not simply their presence or absence – the dawn of molecular genetics.<ref name="Strasser">Template:Cite journal</ref>

His success with sickle cell anemia led Pauling to speculate that a number of other diseases, including mental illnesses such as schizophrenia, might result from flawed genetics. As chairman of the Division of Chemistry and Chemical Engineering and director of the Gates and Crellin Chemical Laboratories, he encouraged the hiring of researchers with a chemical-biomedical approach to mental illness, a direction not always popular with established Caltech chemists.<ref name="LATimes1994">Template:Cite news</ref>Template:Rp

In 1951, Pauling gave a lecture entitled "Molecular Medicine".<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> In the late 1950s, he studied the role of enzymes in brain function, believing that mental illness may be partly caused by enzyme dysfunction. In the 1960s, as part of his interest in the effects of nuclear weapons, he investigated the role of mutations in evolution, proposing with his student Emile Zuckerkandl, the molecular evolutionary clock, the idea that mutations in proteins and DNA accumulate at a constant rate over time .<ref name="Morgan">Template:Cite journal</ref>

Structure of the atomic nucleusEdit

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Pauling in 1962

On September 16, 1952, Pauling opened a new research notebook with the words "I have decided to attack the problem of the structure of nuclei." On October 15, 1965, Pauling published his Close-Packed Spheron Model of the atomic nucleus in two well respected journals, Science and the Proceedings of the National Academy of Sciences.<ref name="SpheronPNAS">Template:Cite journal</ref><ref name="SpheronScience">Template:Cite journal</ref> For nearly three decades, until his death in 1994, Pauling published numerous papers on his spheron cluster model.<ref name=SpheronPNAS/><ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref><ref>Template:Cite journal</ref><ref>Template:Cite journal</ref><ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref><ref>Template:Cite journal</ref>

The basic idea behind Pauling's spheron model is that a nucleus can be viewed as a set of "clusters of nucleons". The basic nucleon clusters include the deuteron [np], helion [pnp], and triton [npn]. Even–even nuclei are described as being composed of clusters of alpha particles, as has often been done for light nuclei.<ref name="Clusters">Template:Cite journal</ref> Pauling attempted to derive the shell structure of nuclei from pure geometrical considerations related to Platonic solids rather than starting from an independent particle model as in the usual shell model. In an interview given in 1990 Pauling commented on his model:<ref name="AOA">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

Now recently, I have been trying to determine detailed structures of atomic nuclei by analyzing the ground state and excited state vibrational bends, as observed experimentally. From reading the physics literature, Physical Review Letters and other journals, I know that many physicists are interested in atomic nuclei, but none of them, so far as I have been able to discover, has been attacking the problem in the same way that I attack it. So I just move along at my own speed, making calculations ...{{#if:|{{#if:|}}
— {{#if:|, in }}Template:Comma separated entries
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ActivismEdit

Wartime workEdit

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Beckman D2 Oxygen Analyzer, ca. 1950

Pauling had been practically apolitical until World War II. At the beginning of the Manhattan Project, Robert Oppenheimer invited him to be in charge of the Chemistry division of the project. He declined, not wanting to uproot his family.<ref name="Hiroshima">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

File:Beckman Model 735 Dissolved O2 Analyzer 2012 002 3598 jm214p459 crop.tiff

Beckman Model 735 Dissolved Template:O2 Analyzer, later model based on Pauling's design, 1968

File:Beckman Model D Oxygen Meter with infant incubator 73666474j.tiff

Beckman Model D Oxygen Meter, based on Pauling's design, with infant incubator, 1959

Pauling did, however, work on research for the military. He was a principal investigator on 14 OSRD contracts.<ref name="Kay2">Template:Cite book</ref> The National Defense Research Committee called a meeting on October 3, 1940, wanting an instrument that could reliably measure oxygen content in a mixture of gases, so that they could measure oxygen conditions in submarines and airplanes. In response Pauling designed the Pauling oxygen meter, which was developed and manufactured by Arnold O. Beckman, Inc. After the war, Beckman adapted the oxygen analyzers for use in incubators for premature babies.<ref name="hundred">Template:Cite book</ref>Template:Rp<ref name="D2OxygenAnalyzer">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

In 1942, Pauling successfully submitted a proposal on "The Chemical Treatment of Protein Solutions in the Attempt to Find a Substitute for Human Serum for Transfusions". His project group, which included Joseph B. Koepfli and Dan H. Campbell, developed a possible replacement for human blood plasma in transfusions: polyoxy gelatin (Oxypolygelatin).<ref name="Oxypolygelatin">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref><ref name="Chadarevian">Template:Cite book</ref>

Other wartime projects with more direct military applications included work on explosives, rocket propellants and the patent for an armor-piercing shell. In October 1948, Pauling, along with Lee A. DuBridge, William A. Fowler, Max Mason, and Bruce H. Sage, was awarded a Presidential Medal for Merit by President Harry S. Truman. The citation credits him for his "imaginative mind", "brilliant success", and "exceptionally meritorious conduct in the performance of outstanding services".<ref name="PMFM">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref><ref name="NLM">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref><ref name="Paulus">Template:Cite news</ref> In 1949, he served as president of the American Chemical Society.<ref name="ACS1949">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

Nuclear activismEdit

The aftermath of the Manhattan Project and his wife Ava's pacifism changed Pauling's life profoundly, and he became a peace activist.Template:Citation needed

In June 1945, a "May-Johnson Bill" began<ref>Template:Citation</ref><ref>Template:Citation</ref><ref>Template:Citation</ref> that would become the Atomic Energy Act of 1946 (signed August 1, 1946). In November 1945, Pauling spoke to the Independent Citizens Committee of the Arts, Sciences and Professions (ICCASP) on atomic weapons; shortly after, wife Ava and he accepted membership.<ref name="PaulingICCASP">Template:Citation</ref> On January 21, 1946, the group met to discuss academic freedom, during which Pauling said, "There is, of course, always a threat to academic freedom – as there is to the other aspects of the freedom and rights of the individual, in the continued attacks which are made on this freedom, these rights, by the selfish, the overly ambitious, the misguided, the unscrupulous, who seek to oppress the great body of mankind in order that they themselves may profit – and we must always be on the alert against this threat, and must fight it with vigor when it becomes dangerous."<ref name=PaulingICCASP/>

In 1946, he joined the Emergency Committee of Atomic Scientists, chaired by Albert Einstein.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> Its mission was to warn the public of the dangers associated with the development of nuclear weapons.

File:Letter from Ruth B. Shipley, Chief Passport Division, Department of State (United States) to Linus Pauling on February 14, 1952.jpg

Denial letter from Ruth B. Shipley, Chief Passport Division, Department of State to Linus Pauling on February 14, 1952

His political activism prompted the US State Department to deny him a passport in 1952, when he was invited to speak at a scientific conference in London.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref><ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> In a speech before the US Senate on June 6 of the same year, Senator Wayne Morse publicly denounced the action of the State Department, and urged the Passport Division to reverse its decision. Pauling and his wife Ava were then issued a "limited passport" to attend the conference.<ref>Robert Paradowski (2011), Oregon State University, Special Collections p.18, Proteins, Passports, and the Prize (1950–1954), retrieved February 1, 2013</ref><ref>Bulletin of the Atomic Scientists Vol. VIII, Nr. 7 (Okt. 1952) p. 254, Educational Foundation for Nuclear Science, Inc.</ref> His full passport was restored in 1954, shortly before the ceremony in Stockholm where he received his first Nobel Prize.Template:Citation needed

Joining Einstein, Bertrand Russell and eight other leading scientists and intellectuals, he signed the Russell-Einstein Manifesto issued July 9, 1955.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> He also supported the Mainau Declaration of July 15, 1955, signed by 52 Nobel Prize laureates.<ref name="Snow">Template:Cite book</ref>

In May 1957, working with Washington University in St. Louis professor Barry Commoner, Pauling began to circulate a petition among scientists to stop nuclear testing.<ref name="Tooth">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> On January 15, 1958, Pauling and his wife presented a petition to United Nations Secretary General Dag Hammarskjöld calling for an end to the testing of nuclear weapons. It was signed by 11,021 scientists representing fifty countries.<ref name="NobelLecture">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref><ref name="NobelBlog">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

In February 1958, Pauling participated in a publicly televised debate with the atomic physicist Edward Teller about the actual probability of fallout causing mutations.<ref name="Moore">Template:Cite book</ref> Later in 1958, Pauling published No more war!, in which he not only called for an end to the testing of nuclear weapons but also an end to war itself. He proposed that a World Peace Research Organization be set up as part of the United Nations to "attack the problem of preserving the peace".<ref name="Nobel" />

Pauling also supported the work of the St. Louis Citizen's Committee for Nuclear Information (CNI).<ref name=Tooth/> This group, headed by Barry Commoner, Eric Reiss, M. W. Friedlander and John Fowler, organized a longitudinal study to measure radioactive strontium-90 in the baby teeth of children across North America. The "Baby Tooth Survey", published by Louise Reiss, demonstrated conclusively in 1961 that above-ground nuclear testing posed significant public health risks in the form of radioactive fallout spread primarily via milk from cows that had ingested contaminated grass.<ref>Template:Cite journal</ref><ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref><ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> The Committee for Nuclear Information is frequently credited for its significant contribution to supporting the test ban,<ref name="McCormick">Template:Cite book</ref> as is the ground-breaking research conducted by Reiss and the "Baby Tooth Survey".<ref name="activism">Template:Cite book</ref>

Public pressure and the frightening results of the CNI research led to a moratorium on above-ground nuclear weapons testing, followed by the Partial Test Ban Treaty, signed in 1963 by John F. Kennedy and Nikita Khrushchev. On the day that the treaty went into force, October 10, 1963, the Nobel Prize Committee awarded Pauling the Nobel Peace Prize for 1962. (No prize had previously been awarded for that year.)<ref name="PaloAlto">Template:Cite news</ref> They described him as "Linus Carl Pauling, who ever since 1946 has campaigned ceaselessly, not only against nuclear weapons tests, not only against the spread of these armaments, not only against their very use, but against all warfare as a means of solving international conflicts."<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> Pauling himself acknowledged his wife Ava's deep involvement in peace work, and regretted that she was not awarded the Nobel Peace Prize with him.<ref name="LPIBio">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

Political criticismEdit

File:Linus Pauling's beret at the Nobel Museum (51969).jpg

Pauling's beret on display at the Nobel Prize Museum

Many of Pauling's critics, including scientists who appreciated the contributions that he had made in chemistry, disagreed with his political positions and saw him as a naïve spokesman for Soviet communism. In 1960, he was ordered to appear before the Senate Internal Security Subcommittee,<ref name="Senate">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> which termed him "the number one scientific name in virtually every major activity of the Communist peace offensive in this country".<ref name=Humanism/> A headline in Life magazine characterized his 1962 Nobel Prize as "A Weird Insult from Norway".<ref name="Kovac">Template:Cite journal</ref><ref name="Life">Template:Cite magazine</ref>

Pauling was a frequent target of the National Review magazine. In an article entitled "The Collaborators" in the magazine's July 17, 1962, issue, Pauling was referred to not only as a collaborator, but as a "fellow traveler" of proponents of Soviet-style communism. In 1963, Pauling sued the magazine, its publisher William Rusher, and its editor William F. Buckley, Jr for $1 million. He lost both his libel suits and the 1968 appeal (unlike his earlier 1963 libel case against the Hearst Corporation), because in the meantime the landmark case New York Times Co. v. Sullivan had established the actual malice standard for libel lawsuits by public figures, requiring that not only falsehood but deliberate lying should be proved by the plaintiff in such cases.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref><ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref><ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref><ref>Template:Cite news</ref>

His peace activism, his frequent travels, and his enthusiastic expansion into chemical-biomedical research all aroused opposition at Caltech. In 1958, the Caltech Board of Trustees demanded that Pauling step down as chairman of the Chemistry and Chemical Engineering Division.<ref name=LATimes1994/>Template:Rp Although he had retained tenure as a full professor, Pauling chose to resign from Caltech after he received the Nobel peace prize money. He spent the next three years at the Center for the Study of Democratic Institutions (1963–1967).<ref name="Abrams" /> In 1967, he moved to the University of California at San Diego, but remained there only briefly, leaving in 1969 in part because of political tensions with the Reagan-era board of regents.<ref name=LATimes1994/>Template:Rp From 1969 to 1974, he accepted a position as professor of chemistry at Stanford University.<ref name="OH" />

Vietnam war activismEdit

During the 1960s, President Lyndon Johnson's policy of increasing America's involvement in the Vietnam War caused an anti-war movement that the Paulings joined with enthusiasm. Pauling denounced the war as unnecessary and unconstitutional. He made speeches, signed protest letters and communicated personally with the North Vietnamese leader, Ho Chi Minh, and gave the lengthy written response to President Johnson. His efforts were ignored by the American government.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

File:27. Tagung 1977 Chemiker; Linus C. Pauling Porträt - W134Nr.108890d - Willy Pragher.jpg

Pauling in 1977

Pauling was awarded the International Lenin Peace Prize by the USSR in 1970.<ref name="Humanism">Template:Cite journal</ref><ref name="LeninPrize">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> He continued his peace activism in the following years. He and his wife Ava helped to found the International League of Humanists in 1974.<ref name="HumanistFounders">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> He was president of the scientific advisory board of the World Union for Protection of Life and also one of the signatories of the Dubrovnik–Philadelphia statement of 1974/1976.<ref name="Dubrovnik">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> Linus Carl Pauling was an honorary president and member of the International Academy of Science, Munich, until the end of his life.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

Pauling was also a supporter of the Fair Play for Cuba Committee.<ref>Template:Cite book</ref>

Global activismEdit

He was one of the signatories of the agreement to convene a convention for drafting a world constitution.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref><ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> As a result, for the first time in human history, a World Constituent Assembly convened to draft and adopt a Constitution for the Federation of Earth.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

EugenicsEdit

Pauling supported a limited form of eugenics by suggesting that human carriers of defective genes be given a compulsory visible mark – such as a forehead tattoo – to discourage potential mates with the same defect, in order to reduce the number of babies with diseases such as sickle cell anemia.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref><ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

Medical research and vitamin C advocacyEdit

{{#invoke:Labelled list hatnote|labelledList|Main article|Main articles|Main page|Main pages}}

File:Pauling Vit C Book Cover.jpg

Pauling's book, How to Live Longer and Feel Better, advocated very high intake of Vitamin C.<ref>Template:Cite book</ref>

In 1941, at age 40, Pauling was diagnosed with Bright's disease, a renal disease. Following the recommendations of Thomas Addis, who actively recruited Ava Helen Pauling as "nutritionist, cook, and eventually as deputy 'doctor'", Pauling believed he was able to control the disease with Addis's then-unusual low-protein salt-free diet and vitamin supplements.<ref>Template:Cite book</ref> Thus Pauling's initial – and intensely personal – exposure to the idea of treating disease with vitamin supplements was positive.Template:Citation needed

In 1965, Pauling read Niacin Therapy in Psychiatry by Abram Hoffer and theorized vitamins might have important biochemical effects unrelated to their prevention of associated deficiency diseases.<ref>Template:Cite book</ref> In 1968, Pauling published a brief paper in Science entitled "Orthomolecular psychiatry",<ref>Template:Cite journal</ref> giving a name to the popular but controversial megavitamin therapy movement of the 1970s, and advocating that "orthomolecular therapy, the provision for the individual person of the optimum concentrations of important normal constituents of the brain, may be the preferred treatment for many mentally ill patients." Pauling coined the term "orthomolecular" to refer to the practice of varying the concentration of substances normally present in the body to prevent and treat disease. His ideas formed the basis of orthomolecular medicine, which is not generally practiced by conventional medical professionals and has been strongly criticized.<ref name="Cassileth">Template:Cite book</ref><ref name="bccancer">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

In 1973, with Arthur B. Robinson and another colleague, Pauling founded the Institute of Orthomolecular Medicine in Menlo Park, California, which was soon renamed the Linus Pauling Institute of Science and Medicine. Pauling directed research on vitamin C, but also continued his theoretical work in chemistry and physics until his death. In his last years, he became especially interested in the possible role of vitamin C in preventing atherosclerosis and published three case reports on the use of lysine and vitamin C to relieve angina pectoris. During the 1990s, Pauling put forward a comprehensive plan for the treatment of heart disease using lysine and vitamin C. In 1996, a website was created expounding Pauling's treatment which it referred to as Pauling Therapy. Proponents of Pauling Therapy believe that heart disease can be treated and even cured using only lysine and Vitamin C and without drugs or heart operations.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

Pauling's work on vitamin C in his later years generated much controversy. He was first introduced to the concept of high-dose vitamin C by biochemist Irwin Stone in 1966. After becoming convinced of its worth, Pauling took 3 grams of vitamin C every day to prevent colds.<ref name="frs" /> Excited by his own perceived results, he researched the clinical literature and published Vitamin C and the Common Cold in 1970. He began a long clinical collaboration with the British cancer surgeon Ewan Cameron in 1971 on the use of intravenous and oral vitamin C as cancer therapy for terminal patients.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> Cameron and Pauling wrote many technical papers and a popular book, Cancer and Vitamin C, that discussed their observations. Pauling made vitamin C popular with the public<ref name="OnThisDay">Template:Cite news</ref> and eventually published two studies of a group of 100 allegedly terminal patients that claimed vitamin C increased survival by as much as four times compared to untreated patients.<ref>Template:Cite journal</ref><ref>Template:Cite journal</ref>

A re-evaluation of the claims in 1982 found that the patient groups were not actually comparable, with the vitamin C group being less sick on entry to the study, and judged to be "terminal" much earlier than the comparison group.<ref>Template:Cite journal</ref> Later clinical trials conducted by the Mayo Clinic led by oncologist Dr. Edward T. Creagan also concluded that high-dose (10,000 mg) vitamin C was no better than placebo at treating cancer and that there was no benefit to high-dose vitamin C.<ref>Template:Cite journal</ref><ref>Template:Cite journal</ref><ref>Template:Cite journal</ref> The failure of the clinical trials to demonstrate any benefit resulted in the conclusion that vitamin C was not effective in treating cancer; the medical establishment concluded that his claims that vitamin C could prevent colds or treat cancer were quackery.<ref name="frs" /><ref name="PNASChen2007">Template:Cite journal</ref> Pauling denounced the conclusions of these studies and handling of the final study as "fraud and deliberate misrepresentation",<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref><ref name="Golem">Template:Cite book</ref> and criticized the studies for using oral, rather than intravenous vitamin C<ref>Template:Cite journal</ref> (which was the dosing method used for the first ten days of Pauling's original study<ref name=PNASChen2007/>). Pauling also criticised the Mayo Clinic studies because the controls were taking vitamin C during the trial, and because the duration of the treatment with vitamin C was short; Pauling advocated continued high-dose vitamin C for the rest of the cancer patient's life whereas the Mayo Clinic patients in the second trial were treated with vitamin C for a median of 2.5 months.<ref>Template:Cite book</ref>

Ultimately the negative findings of the Mayo Clinic studies ended general interest in vitamin C as a treatment for cancer.<ref name = Golem/> Despite this, Pauling continued to promote vitamin C for treating cancer and the common cold, working with The Institutes for the Achievement of Human Potential to use vitamin C in the treatment of brain-injured children.<ref name="Pauling1978">Template:Cite journal</ref> He later collaborated with the Canadian physician Abram Hoffer on a micronutrient regime, including high-dose vitamin C, as adjunctive cancer therapy.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> A 2009 review also noted differences between the studies, such as the Mayo Clinic not using intravenous Vitamin C, and suggested further studies into the role of vitamin C when given intravenously.<ref name="Cancerreevaluated">Template:Cite journal</ref> Results from most clinical trials suggest that modest vitamin C supplementation alone or with other nutrients offers no benefit in the prevention of cancer.<ref name="Oncologist">Template:Cite journal</ref><ref name="NIHFactsheet">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

Personal lifeEdit

File:Linus Pauling family 1954.jpg

The Pauling children at a gathering in celebration of the 1954 Nobel Prizes in Stockholm, Sweden. Seated from left: Linus Pauling, Jr., Peter Pauling and Linda Pauling. Standing from left: an unidentified person, and Crellin Pauling

Pauling married Ava Helen Miller on June 17, 1923. The marriage lasted until her death in 1981. They had four children.<ref name="family">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> Linus Carl Jr. (1925–2023) became a psychiatrist;<ref>Template:Cite news</ref> Peter (1931–2003) a crystallographer at University College London;<ref>Template:Cite book</ref> Edward Crellin (1937–1997) a biologist;<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> and Linda Helen (born 1932) married noted Caltech geologist and glaciologist Barclay Kamb.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

Pauling was raised as a member of the Lutheran Church,<ref name="AIPOralHistory">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> but later joined the Unitarian Universalist Church.<ref name="UUBio">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> Two years before his death, in a published dialogue with Buddhist philosopher Daisaku Ikeda, Pauling publicly declared his atheism.<ref>Template:Cite book</ref>

On January 30, 1960, Pauling and his wife were using a cabin about Template:Convert south of Monterey, California, and he decided to go for a walk on a coastal trail. He got lost and tried to climb the rocky cliff, but reached a large overhanging rock about Template:Convert above the ocean. He decided it was safest to stay there, and meanwhile he was reported missing. He spent a sleepless night on the cliff before being found after almost 24 hours.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

Death and legacyEdit

Pauling died of prostate cancer on August 19, 1994, at 19:20 at home in Big Sur, California.<ref name="Offit" /> He was 93 years old.<ref>Goertzel and Goertzel, p. 247.</ref> A grave marker for Pauling was placed in Oswego Pioneer Cemetery in Lake Oswego, Oregon by his sister Pauline, but Pauling's ashes, along with those of his wife, were not buried there until 2005.<ref name="grave">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

Pauling's discoveries led to decisive contributions in a diverse array of areas including around 350 publications in the fields of quantum mechanics, inorganic chemistry, organic chemistry, protein structure, molecular biology, and medicine.<ref name="California">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref><ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

His work on chemical bonding marks him as one of the founders of modern quantum chemistry.<ref name="natureobit" /> The Nature of the Chemical Bond was the standard work for many years,<ref name="Hamilton">Template:Cite book</ref> and concepts like hybridization and electronegativity remain part of standard chemistry textbooks. While his valence bond approach fell short of accounting quantitatively for some of the characteristics of molecules, such as the color of organometallic complexes, and would later be eclipsed by the molecular orbital theory of Robert Mulliken, valence bond theory still competes, in its modern form, with molecular orbital theory and density functional theory (DFT) as a way of describing chemical phenomena.<ref>Template:Cite journal</ref> Pauling's work on crystal structure contributed significantly to the prediction and elucidation of the structures of complex minerals and compounds.<ref name=Marinacci/>Template:Rp His discovery of the alpha helix and beta sheet is a fundamental foundation for the study of protein structure.<ref name="Goertzel and Goertzel, p. 95-100" />

Francis Crick acknowledged Pauling as the "father of molecular biology".<ref name="natureobit" /><ref>Template:Cite news</ref> His discovery of sickle cell anemia as a "molecular disease" opened the way toward examining genetically acquired mutations at a molecular level.<ref name=Strasser/>

Pauling's 1951 publication with Robert B. Corey and H. R. Branson, "The Structure of Proteins: Two Hydrogen-Bonded Helical Configurations of the Polypeptide Chain," was a key early finding in the then newly emerging field of molecular biology. This publication was honored by a Citation for Chemical Breakthrough Award from the Division of History of Chemistry of the American Chemical Society presented to the department of chemistry, Caltech, in 2017.<ref name="breakthrough">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref><ref name="configurations">Template:Cite journal</ref>

CommemorationsEdit

Oregon State University completed construction of the $77 million, Template:Convert Linus Pauling Science Center in the late 2000s, now housing the bulk of Oregon State's chemistry classrooms, labs, and instruments.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

On March 6, 2008, the United States Postal Service released a 41 cent stamp honoring Pauling designed by artist Victor Stabin.<ref>Template:Cite news</ref><ref name="stamp">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> His description reads: "A remarkably versatile scientist, structural chemist Linus Pauling (1901–1994) won the 1954 Nobel Prize in Chemistry for determining the nature of the chemical bond linking atoms into molecules. His work in establishing the field of molecular biology; his studies of hemoglobin led to the classification of sickle cell anemia as a molecular disease."<ref name=Strasser/> The other scientists on this sheet of stamps included Gerty Cori, biochemist, Edwin Hubble, astronomer, and John Bardeen, physicist.<ref name="stamp" />

California Governor Arnold Schwarzenegger and First Lady Maria Shriver announced on May 28, 2008, that Pauling would be inducted into the California Hall of Fame, located at The California Museum for History, Women and the Arts. The induction ceremony took place December 15, 2008. Pauling's son Linus Jr. was asked to accept the honor in his place.<ref name="CA.gov">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

By proclamation of Gov. John Kitzhaber in the state of Oregon, February 28 has been named "Linus Pauling Day".<ref name=Notebooks/> The Linus Pauling Institute still exists, but moved in 1996 from Palo Alto, California, to Corvallis, Oregon, where it is part of the Linus Pauling Science Center at Oregon State University.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref><ref name="CGT2011">Template:Cite news</ref><ref name="OSUFoundation">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref> The Valley Library Special Collections at Oregon State University contain the Ava Helen and Linus Pauling Papers, including digitized versions of Pauling's forty-six research notebooks.<ref name="Notebooks">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

In 1986, Caltech commemorated Linus Pauling with a symposium and lectureship.<ref name="Zewail">Template:Cite book</ref> The Pauling Lecture series at Caltech began in 1989 with a lecture by Pauling himself. The Caltech Chemistry Department renamed room 22 of Gates Hall the Linus Pauling Lecture Hall, since Pauling spent so much time there.<ref name="Baum">Template:Cite journal</ref>

Other places named after Pauling include Pauling Street in Foothill Ranch, California;<ref name="Factory">Template:Cite news</ref> Linus Pauling Drive in Hercules, California; Linus and Ava Helen Pauling Hall at Soka University of America in Aliso Viejo, California;<ref name="Gottlieb">Template:Cite news</ref> Linus Pauling Middle School in Corvallis, Oregon;<ref name="Woodward">Template:Cite news</ref> and Pauling Field, a small airfield located in Condon, Oregon, where Pauling spent his youth.<ref name="Airport">Template:Cite news</ref> There is a psychedelic rock band in Houston, Texas, named The Linus Pauling Quartet.<ref name="Heberlein">Template:Cite book</ref>

The asteroid 4674 Pauling in the inner asteroid belt, discovered by Eleanor F. Helin, was named after Linus Pauling in 1991, on his 90th birthday.<ref name="Schmadel">Template:Cite book</ref>

Linus Torvalds, developer of the Linux kernel, is named after Pauling.<ref name="moody">Template:Cite book</ref>

Nobel laureate Peter Agre has said that Linus Pauling inspired him.<ref>Template:Cite journal Template:Cbignore</ref>

In 2010, Pacific Northwest National Laboratory named its distinguished postdoctoral program in his honor, as the Linus Pauling Distinguished Postdoctoral Fellowship Program.<ref>{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

Honors and awardsEdit

Pauling received numerous awards and honors during his career, including the following:<ref name="summary">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref><ref name="OH" /><ref name="honors">{{#invoke:citation/CS1|citation |CitationClass=web }}</ref>

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1931 ACS Award in Pure Chemistry<ref>{{#invoke:citation/CS1|citation

|CitationClass=web }}</ref>

1931 Irving Langmuir Award, American Chemical Society.<ref name="OH" /><ref name=honors/>
1933 Elected Member of the United States National Academy of Sciences<ref>{{#invoke:citation/CS1|citation

|CitationClass=web }}</ref>

1936 Elected Member of the United States American Philosophical Society<ref>{{#invoke:citation/CS1|citation

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1940 Alpha Chi Sigma, professional chemistry fraternity.<ref name="Chi1940">{{#invoke:citation/CS1|citation

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1941 Nichols Medal, New York Section, American Chemical Society.<ref name="OH" />
1944 Elected Member of the American Academy of Arts and Sciences<ref>{{#invoke:citation/CS1|citation

|CitationClass=web }}</ref>

1946 Willard Gibbs Award, Chicago section of the American Chemical Society.<ref name=honors/>
1947 Davy Medal, Royal Society.<ref name="OH" /><ref name=honors/>
1947 T. W. Richards Medal, Northeastern Section of the American Chemical Society.<ref name=honors/>
1948 Presidential Medal for Merit by President Harry S. Truman of the United States.<ref name="OH" /><ref name=honors/>
1948 Elected a Foreign Member of the Royal Society of London (ForMemRS)<ref name="frs" />
1951 Gilbert N. Lewis medal, California section of the American Chemical Society.<ref name=honors/>
1952 Pasteur Medal, Biochemical Society of France.<ref name="OH" /><ref>{{#invoke:citation/CS1|citation

|CitationClass=web }}</ref>

1954 Nobel Prize in Chemistry.<ref name="OH" /><ref name=honors/>
1955 Addis Medal, National Nephrosis Foundation.<ref name="OH" /><ref name=honors/>
1955 John Phillips Memorial Award, American College of Physicians.<ref name="OH" /><ref name=honors/>
1956 Avogadro Medal, Italian Academy of Science.<ref name="OH" /><ref name=honors/>
1957 Paul Sabatier Medal.
1957 Pierre Fermat Medal in Mathematics (awarded for only the sixth time in three centuries).<ref name="OH" /><ref name=honors/><ref>Pauling's awards and medals (includes image of Fermat medal).</ref>
1957 International Grotius Medal.<ref name="OH" />
1959 Messenger Lectureship
1960 Fellow, Royal Society of Arts
1961 Humanist of the Year, American Humanist Association.
1961 Gandhi Peace Award by Promoting Enduring Peace.<ref>{{#invoke:citation/CS1|citation

|CitationClass=web }}</ref>

1962 Nobel Peace Prize.<ref name="OH" /><ref name=honors/>
1965 Medal, Academy of the Rumanian People's Republic.<ref name="OH" />
1966 Linus Pauling Award.<ref name="OH" />
1966 Silver Medal, Institute of France.<ref name="OH" />
1966 Supreme Peace Sponsor, World Fellowship of Religion.<ref name="OH" />
1967 Washington A. Roebling Medal, Mineralogical Society of America.<ref name=honors/>
1972 Lenin Peace Prize.<ref name="OH" />
1974 National Medal of Science by President Gerald R. Ford of the United States.<ref name=honors/>
1978 Lomonosov Gold Medal, Presidium of the Academy of the USSR.<ref name="OH" /><ref name=honors/>
1979 Gold Medal Honoree, National Institute of Social Sciences.<ref>{{#invoke:citation/CS1|citation

|CitationClass=web }}</ref>

1979 NAS Award in Chemical Sciences, National Academy of Sciences.<ref name="OH" /><ref name="Chemical">{{#invoke:citation/CS1|citation

|CitationClass=web }}</ref>

1979 Golden Plate Award, American Academy of Achievement<ref>{{#invoke:citation/CS1|citation

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1981 John K. Lattimer Award, American Urological Association.<ref name=honors/>
1984 Priestley Medal, American Chemical Society.<ref name="OH" /><ref name=honors/>
1984 Award for Chemistry, Arthur M. Sackler Foundation.<ref name="OH" />
1986 Lavoisier Medal by Fondation de la Maison de la Chimie.<ref name=honors/>
1987 Award in Chemical Education, American Chemical Society.<ref name="OH" />
1989 Vannevar Bush Award, National Science Board.<ref name="OH" /><ref name=honors/>
1990 Richard C. Tolman Medal, American Chemical Society Southern California Section.<ref name="OH" />
1992 Daisaku Ikeda Medal, Soka Gakkai International<ref name=honors/>
2008 "American Scientists" U.S. postage stamp series, $0.41, for his sickle cell disease work.<ref>{{#invoke:citation/CS1|citation